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Antineutrophil Cytoplasmic Antibodies (ANCA)

Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
Also Known As:
ANCA; Anti-Neutrophil Cytoplasmic Antibody; Antineutrophil Cytoplasmic Antibody; Antibodies, Antineutrophil Cytoplasmic; Anti-Neutrophil Cytoplasmic Antibodies; Anti Neutrophil Cytoplasmic Antibodies; Anti Neutrophil Cytoplasmic Antibody; Anti Neutrophil Cytoplasmic Autoantibodies; Anti Neutrophil Cytoplasmic Autoantibody; Antibody, Anti-Neutrophil Cytoplasmic; Antibody, Antineutrophil Cytoplasmic; Autoantibody, Anti-Neutrophil Cytoplasmic; Autoantibody, Neutrophil Cytoplasmic; Cytoplasmic Antibody, Anti-Neutrophil; Cytoplasmic Antibody, Antineutrophil; Cytoplasmic Autoantibody, Anti-Neutrophil; Cytoplasmic Autoantibody, Neutrophil; c ANCA; p ANCA; Anti-Neutrophil Cytoplasmic Autoantibodies; Anti-Neutrophil Cytoplasmic Autoantibody; Neutrophil Cytoplasmic Autoantibodies; Neutrophil Cytoplasmic Autoantibody; c-ANCA; p-ANCA
Networked: 7733 relevant articles (368 outcomes, 752 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Specks, Ulrich: 96 articles (05/2022 - 05/2002)
2. Chen, Min: 86 articles (01/2022 - 11/2002)
3. Zhao, Ming-Hui: 84 articles (01/2021 - 05/2004)
4. Merkel, Peter A: 80 articles (05/2022 - 04/2003)
5. Lee, Sang-Won: 78 articles (11/2022 - 03/2017)
6. Park, Yong-Beom: 78 articles (11/2022 - 03/2017)
7. Guillevin, Loïc: 77 articles (01/2022 - 10/2004)
8. Song, Jason Jungsik: 72 articles (11/2022 - 03/2017)
9. Falk, Ronald J: 69 articles (09/2022 - 01/2001)
10. Kallenberg, Cees G M: 69 articles (02/2022 - 01/2002)

Related Diseases

1. Vasculitis (Vasculitides)
2. Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
04/01/2011 - "A total of 350 samples (8.3%) were positive for ANCA on indirect immunofluorescence (IIF), out of which 212 were guideline recommended and 138 (3.2%) were non-guideline recommended ANCA requests; thus, 3.2% of non-small vessel ANCA associated vasculitis (non-SVAAV) conditions showed false positive results when the population was otherwise unselected. "
01/01/2021 - "Biologics may also be an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, particularly in patients with resistance to standard treatments. "
01/01/2021 - "Advances in the diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have led to continued improvement in survival and prognosis over the course of the last 4 decades. "
01/01/2022 - "B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy of B cell depletion in treatment of AAV patients in the current study; we aimed to investigate the frequency of a specific B cell subset, IgD-CD27hiCD38hi B cells in AAV patients, and its association with the disease severity of AAV. "
01/01/2018 - "A post hoc analysis was conducted using participants enrolled in two randomized, placebo-controlled clinical trials who had active GN due to ANCA-associated vasculitis, had positive ANCA, and achieved remission by month 6. Dipstick and microscopic urinalyses were performed at each visit. "
3. Glomerulonephritis
4. Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
5. Systemic Vasculitis

Related Drugs and Biologics

1. Antineutrophil Cytoplasmic Antibodies (ANCA)
2. Rituximab (Mabthera)
3. Cyclophosphamide (Cytoxan)
4. Peroxidase (Myeloperoxidase)
5. Myeloblastin (Proteinase 3)
6. Adrenal Cortex Hormones (Corticosteroids)
7. Steroids
8. Azathioprine (Imuran)
9. Antibodies
10. Autoantibodies

Related Therapies and Procedures

1. Therapeutics
2. Remission Induction
3. Plasma Exchange
4. Aftercare (After-Treatment)
5. Kidney Transplantation