Abstract | OBJECTIVE: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medications. Recent reports indicate that the obesity medication lorcaserin, a 5-hydroxytryptamine (5-HT, serotonin) 2C receptor (5-HT2CR) agonist, improves glycemic control in association with weight loss in obese patients with T2D. Here we evaluate whether lorcaserin has an effect on glycemia without body weight loss and how this effect is achieved. METHODS: RESULTS: CONCLUSIONS: These data suggest that lorcaserin's action within the brain represents a mechanistically novel treatment for T2D: findings of significance to a prevalent global disease.
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Authors | Luke K Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J Low, Martin G Myers, Justin J Rochford, Mark L Evans, Lora K Heisler |
Journal | Molecular metabolism
(Mol Metab)
Vol. 6
Issue 10
Pg. 1092-1102
(10 2017)
ISSN: 2212-8778 [Electronic] Germany |
PMID | 29031711
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved. |
Chemical References |
- Benzazepines
- Blood Glucose
- Melanocortins
- Receptor, Serotonin, 5-HT2C
- Receptors, Melanocortin
- lorcaserin
- Glucose
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Topics |
- Animals
- Benzazepines
(metabolism, pharmacology)
- Blood Glucose
(drug effects)
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(drug therapy)
- Disease Models, Animal
- Eating
(drug effects)
- Energy Metabolism
(drug effects)
- Glucose
(metabolism)
- Glucose Tolerance Test
- Homeostasis
(physiology)
- Humans
- Insulin Resistance
(physiology)
- Melanocortins
(pharmacology)
- Mice
- Mice, Transgenic
- Obesity
(drug therapy)
- Receptor, Serotonin, 5-HT2C
(drug effects)
- Receptors, Melanocortin
(drug effects)
- Weight Loss
(drug effects)
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