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Pro-Opiomelanocortin (Proopiomelanocortin)

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Also Known As:
Proopiomelanocortin; POMC; ACTH-Endorphin Precursor; ACTH-beta-Lipotropin Precursor; Corticotropin-beta-Lipotropin Precursor; Endorphin-ACTH Precursor; Opiocortin; Pre-POMC; Pre-pro-opiocortin; Preproopiomelanocortin; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Proopiocortin; ACTH Endorphin Precursor; ACTH beta Lipotropin Precursor; Corticotropin beta Lipotropin Precursor; Endorphin ACTH Precursor; Pre POMC; Pre pro opiocortin; Pro ACTH Endorphin; Pro Opio Melanocortin; Pro Opiocortin; Pro Opiomelanocortin; Pro-Opiocortin; Opiomelanocortin, pro-
Networked: 1936 relevant articles (58 outcomes, 230 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Low, Malcolm J: 33 articles (11/2021 - 06/2003)
2. O'Rahilly, Stephen: 20 articles (01/2020 - 08/2002)
3. White, Anne: 19 articles (01/2022 - 08/2002)
4. Cowley, Michael A: 17 articles (01/2021 - 06/2003)
5. Rubinstein, Marcelo: 17 articles (01/2020 - 06/2003)
6. Elmquist, Joel K: 17 articles (01/2018 - 08/2002)
7. Xu, Yong: 16 articles (12/2021 - 11/2009)
8. Horvath, Tamas L: 16 articles (01/2021 - 03/2004)
9. Lowell, Bradford B: 15 articles (01/2020 - 06/2004)
10. Wagner, Edward J: 14 articles (01/2021 - 10/2005)

Related Diseases

1. Obesity
2. Insulin Resistance
3. AIDS-Related Complex (ARC)
4. Body Weight (Weight, Body)
5. Weight Loss (Weight Reduction)

Related Drugs and Biologics

1. Pro-Opiomelanocortin (Proopiomelanocortin)
2. Glucose (Dextrose)
3. Leptin
4. setmelanotide
5. Peptides (Polypeptides)
6. Messenger RNA (mRNA)
7. Melanocyte-Stimulating Hormones (MSH)
8. Leptin Receptors
9. Amphetamine (Amfetamine)
10. Cocaine (Cocaine HCl)

Related Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Thymectomy
4. Gastric Bypass (Roux-en-Y Gastric Bypass)
5. Gastroplasty (Vertical-Banded Gastroplasty)