Appetite Depressants (Anorectics)

Agents that are used to suppress appetite.

Also Known As:

Anorectics; Appetite Suppressants; Anorectic Agents; Anorexic Drugs; Anorexigenic Drugs; Appetite-Depressing Drugs; Appetite-Suppressant Drugs; Agent, Anorectic; Agents, Anorectic; Appetite Depressing Drug; Appetite Depressing Drugs; Appetite Suppressant Drug; Appetite Suppressant Drugs; Depressant, Appetite; Depressants, Appetite; Drug, Anorexic; Drug, Anorexigenic; Drug, Appetite-Depressing; Drug, Appetite-Suppressant; Drugs, Anorexic; Drugs, Anorexigenic; Drugs, Appetite-Depressing; Drugs, Appetite-Suppressant; Suppressant, Appetite; Suppressants, Appetite; Anorectic; Anorectic Agent; Anorexic Drug; Anorexigenic Drug; Appetite Depressant; Appetite Suppressant; Appetite-Depressing Drug; Appetite-Suppressant Drug

Networked: 1394 relevant articles (56 outcomes, 112 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Anti-Obesity Agents: 656
      - Appetite Depressants: 1394

Experts

1.	Meguid, Michael M: 11 articles (01/2006 - 01/2003)
2.	Laviano, Alessandro: 9 articles (07/2013 - 01/2002)
3.	Lutz, Thomas A: 8 articles (01/2022 - 05/2003)
4.	Heisler, Lora K: 7 articles (12/2016 - 06/2003)
5.	Riediger, Thomas: 6 articles (06/2017 - 05/2003)
6.	Ramos, Eduardo J B: 6 articles (08/2005 - 02/2004)
7.	Humbert, Marc: 5 articles (12/2022 - 01/2004)
8.	Borner, Tito: 5 articles (01/2022 - 06/2017)
9.	Hayes, Matthew R: 5 articles (01/2020 - 03/2016)
10.	Inui, Akio: 5 articles (01/2020 - 07/2004)

Related Diseases

1.	Obesity 01/01/2008 - "If appetite suppressants are to become a more important tool in obesity treatment, agents that do not lose efficacy when administered for extended periods of time must be identified." 11/01/1995 - "The overall pattern of results to date suggests that selective 5-HT2C agonists may be novel anorectic drugs and prove useful in the treatment of obesity. " 08/01/1992 - "Dexenfluramine, an effective and safe serotoninergic drug with anorectic and possible food-selection-tuning properties, was investigated in a placebo-controlled study of 1 year's duration in severe and refractory obesity. " 07/01/2009 - "Collectively, these data demonstrate that the anorectic and weight-reducing actions of centrally administered NMU and NMS are mediated predominantly by NMUR2, suggesting that NMUR2-selective agonists may be useful for the treatment of obesity." 10/01/1993 - "The apparent short-term efficacy of these appetite-suppressant drugs and the lack of severe adverse drug effects or addiction suggest that they may be useful in the treatment of obesity. "
2.	Weight Loss (Weight Reduction) 03/01/1996 - "Recent studies have documented the safety and efficacy of certain appetite suppressants for assisting in long-term weight loss and maintenance of weight loss. " 11/10/2021 - "The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials." 01/01/2019 - "The appetite suppressants showed a significant weight loss compared with placebo (mean difference [MD], -4.70 kg; 95% CI, -5.25 to -4.15; I2 = 100%; 43 studies). " 04/30/2004 - "The example regarding the study of the effectiveness of an appetite suppressant in weight loss in obese woman as described in Brownell and Stunkard (Am. J. " 05/01/1998 - "While anorectic combinations such as DFEN/PHEN may be effective at promoting weight loss and reducing food intake, future studies on their specificity, safety and efficacy are warranted."
3.	Type 2 Diabetes Mellitus (MODY) 07/01/2013 - "The development of obesity, often in association with type 2 diabetes mellitus (T2DM), reflects a dysregulation of metabolic, anorectic and orexigenic pathways in multiple organs. " 07/01/2019 - "Conclusion: We identified the selective modulation of hepatocyte ERα as a pharmacologic strategy to induce sufficient anorectic hepatokine Gdf15 to prevent experimental obesity, type 2 diabetes, and NAFLD." 09/01/1997 - "Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). " 12/01/1992 - "Anorectic agents have been shown to improve insulin action in NIDDM, irrespective of weight reduction. " 02/01/1992 - "Anorectic agents have been shown to improve insulin action in NIDDM, irrespective of weight reduction. "
4.	Body Weight (Weight, Body) 11/15/2017 - "Therefore, the current study characterized the anorectic and reducing body weight actions of (p-ClPhSe)2 in Sprague-Dawley rats. " 11/01/2017 - "It has been used in laboratory settings to test the effects of anorectic drugs and behavior manipulations such as slowing eating, and to study relationships between demographics and body weight. " 01/01/1991 - "Catamnestic studies of psychotherapeutically treated anorectic patients show that the pathological attitudes and convictions regarding food, eating habits and body weight persist regardless of whether the treatment was successful or not. " 03/01/1980 - "The authors describe the psychiatric and hyperalimentation treatment for four severely anorectic patients who had lost up to 44% of their body weight before entering the study. " 09/15/2023 - "While the mono-agonists exerted little to no body weight lowering and anorectic effects in WT or RAMP1/3 KO mice, but at the given doses, when both compounds were administered together, they synergistically reduced body weight, with a greater effect observed in KO mice. "
5.	Feeding and Eating Disorders (Eating Disorder) 02/01/1998 - "Therefore, ARL 15849 is a potent, selective, intranasally active anorectic agent which may be useful in the treatment of eating disorders." 03/01/2007 - "Scores on the Eating Attitudes Test-26, Eating Disorder Inventory-2, Brief Symptom Inventory (BSI), BSI Depression subscale, and Mizes Anorectic Cognitions scale significantly improved throughout treatment (all p<0.05); however, body dissatisfaction did not improve. " 09/19/2002 - "In our own studies, healing success was achieved in 54% of the cases; 18% achieved partial remission with remnant symptoms of an unspecific eating disorder, and 28% continued to exhibit anorectic and/or bulimic symptoms. " 10/01/2022 - "Most studies focused on anorectic-type EDs (n.22), while fewer involved bulimic-type EDs (n.9) and eating disorders not otherwise specified (n.2), revealing subtypes-specific patterns of altered cerebellar volume and functionality. " 10/01/2003 - "The study consists in the administration of the Temperament and Character Inventory (TCI) and the Eating Disorder Inventory 2 (EDI-2) to 95 outpatient anorectic women (50 restrictive and 45 binge-purging) and to 92 bulimic outpatient women (78 with and 14 without purging behaviours). "

Related Drugs and Biologics

1.	Fenfluramine
2.	Insulin (Novolin)
3.	Hormones (Hormone)
4.	Glucose (Dextrose)
5.	Dexfenfluramine (Redux)
6.	Fluoxetine (Prozac)
7.	Mazindol (Mazanor)
8.	sibutramine (Meridia)
9.	Islet Amyloid Polypeptide
10.	Liraglutide

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Diet Therapy (Therapy, Diet)
4.	Caloric Restriction
5.	Total Parenteral Nutrition