Abstract | BACKGROUND: METHODS: We compared inflammation by HIV/HCV group in a cohort of 361 HIV infected participants from the HIV-Longitudinal Interrelationships of Viruses and Ethanol study. Inflammatory biomarkers >75th percentile were considered elevated. Associations between HIV/HCV group and elevated biomarkers were analyzed as a composite measure (inflammatory burden) or individually. We defined inflammatory burden as number of concurrently elevated biomarkers. Biomarkers included interleukin-6 (IL-6), C-reactive protein (CRP), cystatin C, serum amyloid-A (SAA), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10). Covariates: alcohol, liver fibrosis, comorbidities, CD4 count, antiretroviral therapy, substance use. RESULTS: Detectable HIV and HCV RNA (OR = 2.49; 95% CI = 1.05-5.89) and detectable HCV RNA alone (2.95; 1.08-8.01) were independently associated with increased odds of having a greater inflammatory burden compared to undetectable viremia. Elevated IL-10 (7.79; 1.90-31.97) and TNF-α (7.70; 1.42-41.83) were independently associated with detectable HIV and HCV RNA. Elevated IL-10 was also associated with detectable HCV RNA alone (5.51; 1.17, 25.84). CONCLUSIONS: Detectable HIV and HCV replication versus undetectable replication was associated with inflammatory burden and certain inflammatory biomarkers independently of alcohol consumption, liver fibrosis and other comorbidities.
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Authors | Kaku A Armah, Emily K Quinn, Debbie M Cheng, Russell P Tracy, Jason V Baker, Jeffrey H Samet, Matthew S Freiberg |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 13
Pg. 399
(Aug 29 2013)
ISSN: 1471-2334 [Electronic] England |
PMID | 23987993
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Alcohol Drinking
(blood, immunology)
- Biomarkers
(blood)
- Cohort Studies
- Coinfection
(blood, immunology, virology)
- Cross-Sectional Studies
- Female
- HIV Infections
(blood, immunology, virology)
- Hepatitis C
(blood, immunology, virology)
- Humans
- Male
- Middle Aged
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