Substance-Related Disorders (Drug Abuse)

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6011 relevant articles (194 outcomes, 801 trials/studies) found for this Disease

Description: Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.

Also Known As:

Drug Abuse; Substance Abuse; Drug Addiction; Drug Dependence; Substance Dependence; Drug Usage; Addiction, Drug; Addiction, Substance; Sniffing, Glue; Substance Use Disorder; Substance Use Disorders; Substance Addiction; Abuse, Drug; Abuse, Substance; Abuses, Substance; Dependence, Drug; Dependence, Substance; Disorder, Drug Use; Disorder, Substance Use; Drug Use Disorder; Habituation, Drug; Organic Mental Disorders, Substance Induced; Substance Abuses; Usage, Drug; Drug Habituation; Drug Use Disorders; Glue Sniffing; Organic Mental Disorders, Substance-Induced

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Pain (Aches)
3.	Alcoholism (Alcohol Abuse)
4.	Substance-Related Disorders (Drug Abuse)
5.	Anxiety Disorders (Anxiety Disorder)

Experts

1.	Drake, Robert E: 15 articles (01/2008 - 10/2003)
2.	Brunette, Mary F: 9 articles (10/2007 - 10/2003)
3.	Grant, Bridget F: 8 articles (07/2008 - 04/2004)
4.	Green, Alan I: 7 articles (03/2007 - 10/2003)
5.	Xie, Haiyi: 6 articles (10/2006 - 10/2003)
6.	McHugo, Gregory J: 6 articles (10/2006 - 01/2004)
7.	Weiss, Roger D: 5 articles (09/2008 - 11/2005)
8.	Dawson, Deborah A: 5 articles (07/2006 - 04/2004)
9.	Stinson, Frederick S: 5 articles (07/2006 - 04/2004)
10.	Kranzler, Henry R: 4 articles (09/2008 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Substance-Related Disorders:

1.	Carbon MonoxideIBA 10/01/2005 - "Research indicates that clients with co-occurring disorders are highly prone to relapse to substance abuse, even after they have attained full remission. " 12/01/2005 - "Treatment should maximize the use of psychotherapeutic interventions and give first consideration to medications proven effective in the context of co-occurring substance abuse. " 01/01/2007 - "TC treatment, with modifications, has shown considerable promise in treating offenders who have co-occurring mental and substance use disorders, a group that has a mounting prevalence in prison populations. " 10/01/2005 - "METHODS: Existing clinical records of consumers with severe mental illness and co-occurring substance use disorders who had achieved remission and who were interviewed at two or more subsequent follow-up points (12 months after remission) were reviewed. " 01/01/2005 - "The first is to briefly summarize common co-occurring medical illnesses in those manifesting substance use disorders with an emphasis on issues related to providing effective treatment for these diseases in this population. " Order ALL the reference details at left...
2.	Methadone (Dolophine)FDA LinkGeneric 09/18/1989 - "A significant minority of patients has benefited from methadone maintenance therapy, but most patients have continued their drug abuse and drug-related life-styles." 02/01/1977 - "It has been shown that while poor and middle class communities show good results with methadone maintenance approaches, in the area of secondary drug abuse they show marked dissimilarities. " 05/01/2002 - "In conclusion, INH retention time and completion rates were significantly improved by methadone treatment combined with observed INH, whether or not substance abuse counseling was provided. " 12/01/2008 - "AIMS: This study examines the efficacy of the Focus on Families project (currently called Families Facing the Future), a preventive intervention to reduce substance use disorders among children in families with a parent in methadone treatment. " 04/01/1998 - "AIMS: To provide empirically based evaluation data regarding the efficacy of psychopharmacological interventions in opiate substance abuse, the present study employed meta-analytic statistical procedures to determine the effectiveness of methadone hydrochloride as a pharmacotherapeutic agent. " Order ALL the reference details at left...
3.	Cocaine (Cocaine HCl)IBA 12/01/2007 - "Although improvement in psychosocial functioning is a common goal in substance-abuse treatment, the primary outcome measure in most cocaine trials is urinalysis-verified cocaine use. " 11/01/1993 - "However, a significantly greater proportion of the alcohol and cocaine abusers admitted to having relapsed in the previous six months, reported significantly fewer average days of abstinence than the alcohol group since terminating treatment, and were more likely to present urine specimens indicative of recent substance abuse at the six-month follow-up interview. " 05/01/1993 - "OBJECTIVE: The authors compared the efficacy of a multicomponent behavioral treatment and drug abuse counseling for cocaine-dependent individuals. " 12/01/2008 - "This study examined the impact of prior treatment attempts on primary and posttreatment outcomes in a combined sample of cocaine abusers randomized to standard care substance abuse outpatient treatment (SC) or SC plus CM. Participants (N = 393) were categorized according to self-reported prior treatment attempts (0-1, >or=2). " 09/01/2008 - "AIMS: This study examined gender differences among treatment-seeking cocaine-dependent outpatients (e.g., on demographics, psychopathology, and substance abuse). " Order ALL the reference details at left...
4.	Nicotine FDA Link 01/01/2009 - "Agonist replacement therapies are effective for managing substance abuse disorders including nicotine and opioid dependence. " 02/01/2009 - "BACKGROUND: This article tests the hypothesis that remission from substance use disorders is associated with smoking cessation in nicotine dependent young adults. " 02/01/2009 - "Does remission from alcohol and drug use disorders increase the likelihood of smoking cessation among nicotine dependent young adults?" 10/01/2008 - "Twenty-seven healthy volunteers at a medial level of dependence on both cigarettes (nicotine, NCT) and either CAF or ALC, as judged by the DSM-IV-TR criteria for substance dependence, participated in this study. " 08/01/2008 - "[Abstracts of the 2008 Academic Joint Conference of the Japanese Society of Psychiatric Research on Alcohol, the Japanese Forum on Nicotine and Drug Dependence Studies, the Japanese Society for Biomedical Research on Alcohol and the Japanese Medical Society of Alcohol and Drug Studies]" Order ALL the reference details at left...
5.	Dopamine (Intropin)FDA LinkGeneric 07/01/2007 - "In addition to its low-affinity antagonism of D2 dopamine (DA) receptors, we report that l-THP functions as a higher-affinity antagonist at D1 DA receptors and interacts with D3 DA receptors, suggesting that it may be effective for the treatment of drug addiction. " 01/01/2007 - "Although it has been proposed that modulating dopamine transmission would be effective in the treatment of drug dependence, no validation has been provided in humans so far. " 04/01/2009 - "BACKGROUND: Drug addiction researchers have begun to study dopamine partial agonists as potential therapeutic agents. " 01/01/2009 - "Here we describe PET imaging studies that investigate dopamine's involvement in drug abuse in the human brain. " 11/01/2007 - "Imaging studies have provided new insights on the role of dopamine (DA) in drug abuse and addiction in the human brain. " Order ALL the reference details at left...
6.	Antipsychotic Agents (Antipsychotics)IBA 03/01/2001 - "However, there are few studies on the efficacy of antipsychotics on psychopathology and on their repercutions on substance abuse. " 10/01/1980 - "On the basis of present findings the assay would appear to offer promise for clinical application in the adjusting of the dosage of neuroleptic drugs, as well as in the monitoring of drug usage." 09/30/2008 - "One important contributing factor in the high prevalence of drug abuse disorders seen among schizophrenic patients seems to be related to chronic treatment with typical neuroleptics. " 05/01/2007 - "History of drug abuse, use of depot antipsychotics and prior duration of hospitalization were positive predictors of cost of therapy." 05/01/2007 - "Previous duration of hospitalization (RR = 1.00, 95% CI = 1.00 1.01), history of substance abuse (RR = 1.26, 95% CI = 1.05 1.52) and use of depot antipsychotics (RR = 1.22, 95% CI = 1.05 - 1.42) were associated with higher cost of atypical antipsychotic therapy. " Order ALL the reference details at left...
7.	Clozapine (Clozaril)FDA LinkGeneric 01/01/1998 - "This favorable motor side effect profile of clozapine contributes to improved patient outcomes by reducing noncompliance, substance abuse, and suicide, resulting in improved quality of life and savings on health care costs." 10/01/2003 - "However, use of clozapine, the first choice for refractory illness and possibly uniquely effective for patients with comorbid substance abuse, did vary greatly by race. " 10/01/2006 - "RESULTS: Patients using clozapine at the first 6-month period of substance abuse remission (n = 25) were much less likely to relapse over the next year compared with those on other antipsychotic medications (n = 70): 8.0% vs 40.0%, chi(2) = 8.73 (df = 1), P = .003. " 08/01/2002 - "Possible factors that lead to a decrease in suicidality with clozapine include the following: a direct antidepressant action, improved cognitive function and insight, diminished negative symptoms, reduced substance abuse, and improved compliance. " 06/01/2009 - "The early-recovery group was characterized by less severe substance use disorders at baseline and by use of clozapine. " Order ALL the reference details at left...
8.	Morphine (MS Contin)FDA LinkGeneric 08/01/2008 - "Taken together, these studies suggest that Narp modulates both acquisition and extinction of aversive responses to morphine withdrawal and, therefore, may regulate plasticity processes underlying drug addiction." 05/01/1997 - "Specific genetic factors in opioid substance abuse have not been investigated in man, although animal studies suggest that quantitative trait loci (QTLs) can be identified that predispose mice both to morphine and alcohol preference. " 12/01/2008 - "To test whether gene expression regulation in blood cells could be found in drug addiction, we investigated gene expression profiles in peripheral blood mononuclear (PBMC) cells of saline and morphine-treated rats. " 11/01/2008 - "C57BL/6J (B6) and DBA/2J (D2) mice differ in behaviors related to substance abuse, including voluntary morphine consumption and preference in a two-bottle choice paradigm. " 10/15/2008 - "The down-regulation of PC1/3, PC2 and P-CREB by short-term morphine and up-regulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse." Order ALL the reference details at left...
9.	Ibogaine (Endabuse)IBA 09/01/2000 - "Ibogaine has shown preliminary efficacy for opiate detoxification and for short-term stabilization of drug-dependent persons as they prepare to enter substance abuse treatment. " 09/01/2000 - "The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. " 09/01/1996 - "The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. " 07/01/1994 - "Ibogaine may be of value in the present and could serve as a model for the development of improved agents for the treatment of substance abuse in the future." 06/01/2004 - "Combating substance abuse with ibogaine: pre- and posttreatment recommendations and an example of successive model fitting analyses." Order ALL the reference details at left...
10.	Heroin (Diamorphine)IBA 09/05/2007 - "In the present study, 106 heroin addicts (West European, Caucasians) and 70 healthy control subjects matched for race and gender, with no history of substance use disorder, have been genotyped. " 09/01/2006 - "MEASUREMENTS: The following were measured in this study: general health, quality of life, drug-addiction-related problems, nonmedical use of heroin, risk behavior for HIV and HCV, and psychological, family, and social status. " 08/16/2004 - "The study does suggest the need for consideration of sexual partnerships and gender differences in providing drug abuse treatment for heroin users." 04/01/2004 - "In the present study, 101 heroin addicts (males, West European, Caucasians) and 101 healthy control subjects matched for race and gender, with no history of substance use disorder, have been genotyped. " 03/01/2003 - "This study of persons referred to publicly funded drug-free substance abuse treatment in Washington State compares 122 primary heroin users (those specifying heroin as a drug of choice) with 532 persons who preferred other substances. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/2008 - "Furthermore, advancements in the understanding of the genetic and epigenetic basis of drug addiction and the pharmacogenetics of the safety and/or efficacy of the medications are providing opportunities for more individualized pharmacotherapy approaches. " 01/01/2005 - "Further research is needed to better understand the feasibility and efficacy of providing pharmacotherapies for substance dependence disorders within this population." 05/01/1990 - "The pharmacist's knowledge of pharmacotherapy and drug products and skill in assessing and managing problems related to substance abuse allowed physicians and nurses more time for other patient-care activities and helped the behavioral counselors develop a better understanding of the pharmacologic aspects involved in the health care of chemically dependent patients. " 12/01/2002 - "In many cases, pharmacotherapy has been shown to be useful in the treatment of substance abuse and related disorders, both in detoxification and in the prevention of relapse. " 01/01/2009 - "Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach." Order ALL the reference details at left...
2.	Self Administration (Administration, Self) 03/01/2009 - "There are two main versions of the reinstatement model that are employed to study relapse to drug abuse; one based on the operant self-administration procedure, and the other on the classical conditioned place preference procedure. " 04/01/2001 - "CONCLUSIONS: The data of this study are consistent with the view that hypnotic self-administration by insomniacs is therapy-seeking behavior and not drug abuse." 09/01/1998 - "The uniform observation of predominant inhibition among the various electrophysiology studies is consistent with the heuristic value of anesthetized and slice recording methods in identifying potential neurophysiological correlates of drug taking; however, the existence of firing patterns (e.g., phasic increases) uniquely associated with self-administration behavior (and thus absent in anesthetized and slice studies), as well as the unique presence of the primary behavior of interest in studies such as the present one, underscores the importance of conducting electrophysiological investigations of drug taking and drug addiction in the self-administering animal in parallel with anesthetized and slice studies whenever possible." 12/19/1997 - "Further, because acquisition of drug self-administration is an animal model of vulnerability to drug addiction, these inbred strains may be useful to study factors underlying such vulnerability." 05/01/1997 - "Although accumbens DA is important for drug abuse phenomena, particularly stimulant self-administration, studies that involve other reinforcers are more problematic. " Order ALL the reference details at left...
3.	Activities of Daily Living (ADL) 11/15/2004 - "Though psychiatric symptoms improved only modestly, participants improved steadily in terms of remission from substance abuse (61% in full remission at 3 years); they also achieved greater independent living (average 239 days in third year), competitive employment (49% in third year), regular social contacts with nonsubstance abusers (46% at 3 years), and quality of life (56% satisfied with life at 3 years). " 01/01/2003 - "Clients in both conditions improved in life satisfaction, distress, and independent living, while participants in the MHTC also showed reductions in substance abuse and new criminal activity. " 04/01/1996 - "However, the study finding that substance abusers expressed a desire for independent living suggests the need for caution in adhering to homeless mentally ill persons' housing preferences, given the problems posed by substance abuse for their ability to maintain stable community housing." 07/01/2008 - "The eight mediators were service utilization variables: program contacts, phone contacts, substance abuse contacts, assistance with activities of daily living, transportation assistance, help finding permanent housing, help with emotional problems, and medication assistance. " 08/01/2007 - "The variables predicting the SMI status were diagnosis, presence of paid employment, duration of service contact, care packages delivered in 2000 and severity of some HoNOS items (self harm, drug abuse, cognitive problems, delusions, other symptoms, relationships, activities of daily living and housing). " Order ALL the reference details at left...
4.	Prenatal Care 06/01/2000 - "CONCLUSION: Neonatal outcome is significantly improved for infants born to substance abusers who receive substance abuse treatment concurrent with prenatal care compared with infants born to substance abusers who enter treatment postpartum." 01/01/2003 - "CONCLUSION: Improved neonatal outcomes were found among babies whose mothers received substance abuse treatment integrated with prenatal care. " 09/01/2009 - "The study indicates that attendance at a voluntary, low-threshold initiative for pregnant substance abusers, with a focus on prenatal care and substance abuse treatment without replacements, may reduce the harmful effect of the abuse on the newborn." 10/01/2000 - "Factors predicting noncompliance with the study protocol for follow-up were predominantly sociodemographic and included nonwhite race, no insurance, substance abuse, young maternal age, more than two children at home, and late onset of prenatal care. " 06/01/1998 - "METHOD: All prenatal care/substance abuse treatment patients who met study eligibility criteria (N = 84) were assessed by health care providers. " Order ALL the reference details at left...
5.	Highly Active Antiretroviral Therapy (HAART) 01/01/2006 - "Specific support or intervention may be beneficial for those who have failed HAART in order to decrease substance abuse and increase overall physical health." 07/01/2000 - "Some HIV-infected injecting drug users (IDUs) on drug abuse maintenance treatment have access to highly active antiretroviral therapy (HAART); this raises questions about the effects of individual treatments on the efficacy of HAART. " 01/01/2003 - "The study, carried out in the French MANIF 2000 cohort of HIV positive patients contaminated through injecting drug use, assessed the impact of patients' sociodemographic and psychological characteristics, behaviors toward drug abuse, and antiretroviral treatment characteristics on the maintenance of adherence to HAART (highly active antiretroviral therapies). " 06/01/2009 - "The impact of neuropsychological functioning on adherence to HAART in HIV-infected substance abuse patients." 04/01/2009 - "Effective linkages between primary care for HIV and substance abuse treatment may improve HAART outcomes in this population." Order ALL the reference details at left...

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