[A case of Churg-Strauss syndrome with short duration from the onset of asthma to diagnosis of vasculitis].

Abstract

A 68-year-old woman was hospitalized because of bronchial asthma and a high myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) level. She had suffered from rhinitis from one year before hospitalization, body weight loss from three months before, and asthma from one month before. On admission, she complained of dyspnea and body weight loss of over 6 kg. On laboratory tests, high MPO-ANCA and urinary abnormalities were found. On the next day, a renal biopsy was performed and histology showed necrotizing vasculitis with cellular crescents. Churg-Strauss syndrome (CSS) was diagnosed on the basis of the clinical course and histological findings. Prednisolone therapy induced rapid symptom remission, which was achieved within one month from the onset of asthma to the diagnosis of CSS. Early diagnosis and early care led to a good prognosis.

• Authors: Yoshikazu Fuse
• Journal: Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 55 Issue 1 Pg. 71-6 ( 2013) ISSN: 0385-2385 [Print] Japan
• PMID: 23461213 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Prednisolone
• Peroxidase

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Asthma (diagnosis, drug therapy)
• Churg-Strauss Syndrome (diagnosis, drug therapy, pathology)
• Female
• Humans
• Peroxidase (immunology)
• Prednisolone (therapeutic use)
• Treatment Outcome
• Vasculitis (diagnosis, drug therapy, immunology)