Churg-Strauss Syndrome (Allergic Angiitis)

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484 relevant articles (22 outcomes, 17 trials/studies) found for this Disease

Description: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.

Also Known As:

Allergic Angiitis; Syndrome, Churg-Strauss; Vasculitis, Churg Strauss; Allergic Angiitides; Allergic Granulomatous Angiitides; Angiitides, Allergic; Angiitides, Allergic Granulomatous; Angiitis, Allergic; Churg Strauss Syndrome; Churg-Strauss Vasculitis; Granulomatous Angiitides, Allergic; Granulomatous Angiitis, Allergic; Allergic Granulomatous Angiitis; Angiitis, Allergic Granulomatous; Vasculitis, Churg-Strauss

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Vascular Diseases: 7633

Vasculitis: 6757

Churg-Strauss Syndrome: 484

Hemic and Lymphatic Diseases

Lymphatic Diseases: 1961

Lymphoproliferative Disorders: 2359

Granuloma: 6615

Churg-Strauss Syndrome: 484

Related Diseases

1.	Polyarteritis Nodosa (Periarteritis Nodosa)
2.	Wegener Granulomatosis (Wegener's Granulomatosis)
3.	Vasculitis (Vasculitides)
4.	Asthma (Bronchial Asthma)
5.	Syndrome

Experts

1.	Gross, W L: 8 articles (08/2008 - 02/2001)
2.	Hellmich, B: 8 articles (08/2008 - 07/2003)
3.	Higashimoto, Ikkou: 4 articles (09/2008 - 02/2006)
4.	Mitsuyama, Hideo: 4 articles (09/2008 - 02/2006)
5.	Arimura, Kimiyoshi: 4 articles (09/2008 - 02/2006)
6.	Metzler, C: 4 articles (08/2008 - 02/2001)
7.	Giavina-Bianchi, Pedro: 4 articles (07/2008 - 01/2007)
8.	Kalil, Jorge: 4 articles (07/2008 - 01/2007)
9.	Agondi, Rosana: 4 articles (07/2008 - 01/2007)
10.	Mahr, Alfred: 4 articles (06/2007 - 09/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Churg-Strauss Syndrome:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/15/2007 - "OBJECTIVE: To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS). " 05/01/2007 - "Thus cyclophosphamide is only used in patients with generalized disease or - regarding Churg-Strauss-syndrome - patients with risk factors. " 06/01/2002 - "We present a case of a woman diagnosed with Churg-Strauss syndrome that was refractory to corticosteroid and cyclophosphamide treatment. " 12/01/1994 - "To define the most effective treatment for polyarteritis nodosa (PAN) and Churg-Strauss syndrome (CSS), we undertook 4 consecutive prospective therapeutic trials including 236 patients and tried to answer several important questions: Should cyclophosphamide (CYC) be given as the first-line treatment? " 01/01/1992 - "To define the most effective treatment for polyarteritis nodosa (PAN) and Churg-Strauss syndrome (CSS), we undertook 3 consecutive prospective therapeutic trials including 182 patients and tried to answer several important questions: should cyclophosphamide (CYC) be given as the first-line treatment? " Order ALL the reference details at left...
2.	Interferon-alpha (Interferon Alfa)FDA Link 09/01/1998 - "CONCLUSIONS: Interferon-alpha may be an effective treatment for the Churg-Strauss syndrome. " 05/01/2008 - "A phase II study of interferon-alpha for the treatment of refractory Churg-Strauss syndrome." 09/01/1998 - "OBJECTIVE: To study the effect of interferon-alpha on the Churg-Strauss syndrome. " 04/01/2007 - "In addition, interferon-alpha is used for induction treatment particularly in Churg-Strauss syndrome. " 07/04/2003 - "2; male), respectively, suffering from a histologically confirmed Churg-Strauss-syndrome and receiving immunosuppressive therapy were treated with Interferon-alpha. " Order ALL the reference details at left...
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 10/01/2009 - "Churg-Strauss syndrome secondary to antileucotriene therapy in a patient not receiving oral corticosteroids." 08/08/2007 - "In Churg-Strauss syndrome, treatment can be started with high doses of corticosteroids, tapering them when the clinical situation improves. " 03/01/2007 - "PURPOSE: To describe an unusual case of Churg-Strauss syndrome (CSS) that presented with a conjunctival nodule and was successfully treated with oral corticosteroids. " 07/01/2004 - "The patient was finally diagnosed with Churg-Strauss syndrome and was treated with oral corticosteroids. " 06/01/2002 - "The initial management of Churg-Strauss syndrome consists of high doses of corticosteroids. " Order ALL the reference details at left...
4.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 02/01/2009 - "The emergence of antineutrophil cytoplasmic antibodies may precede the clinical onset of Churg-Strauss syndrome." 12/01/2007 - "METHODS: Review of clinical and laboratory findings of a 44-year-old woman with ANCA negative Churg-Strauss syndrome that developed sudden vision loss in left eye. " 11/01/2007 - "The other four patients had perinuclear ANCA, of whom three were asymptomatic and one is currently under surveillance for Churg-Strauss syndrome. " 04/19/2006 - "Thus, cardiac IRM should be considered in patients with ANCA-negative Churg-Strauss syndrome. " 11/01/2005 - "CONCLUSIONS: Phenotypically, ANCA-positive and ANCA-negative Churg-Strauss syndrome might differ. " Order ALL the reference details at left...
5.	Immunoglobulins (Immunoglobulin)IBA 12/01/2004 - "Long term effectiveness of intravenous immunoglobulin in Churg-Strauss syndrome." 01/01/2004 - "Treatment of Churg-Strauss syndrome with high-dose intravenous immunoglobulin." 06/01/2002 - "Churg-Strauss syndrome and pregnancy: successful treatment with intravenous immunoglobulin." 11/01/1991 - "Treatment of Churg-Strauss syndrome with high-dose intravenous immunoglobulin." 12/01/2004 - "CONCLUSION: Complete clinical and functional recovery with a long term stable remission and a low incidence of side effects can be achieved by intravenous immunoglobulin associated with plasmapheresis in patients with Churg-Strauss syndrome." Order ALL the reference details at left...
6.	Prednisolone (Predate)FDA LinkGeneric 11/01/2000 - "Churg-Strauss syndrome was diagnosed and prednisolone was administered with a good response leading to remission. " 09/01/2003 - "A diagnosis of Churg-Strauss syndrome was made and she was treated with 60 mg of prednisolone per day. " 10/01/1999 - "Churg-Strauss syndrome (CSS) was diagnosed, and treatment was initiated with prednisolone at a dose of 60 mg/day. " 07/01/1995 - "A diagnosis of Churg-Strauss syndrome (CSS) was made, and her symptoms were successfully treated with low-dose prednisolone. " 09/01/1994 - "The eosinophil count was 53.5%, therefore Churg-Strauss syndrome was diagnosed and she was given prednisolone (PSL) (30 mg/day). " Order ALL the reference details at left...
7.	Azathioprine (Imuran)FDA LinkGeneric 08/19/2005 - "CONCLUSION: The development of rheumatoid arthritis during remission achieved with azathioprine in Churg-Strauss syndrome of four-year duration is very rare. " 12/10/1974 - "[Effective use of azathioprine in a case of polyarteritis nodosa with recurrent intestinal perforation: a distinction between polyarteritis nodosa and allergic granulomatous angiitis]" 02/01/2003 - "The diagnosis of Churg-Strauss syndrome was established, and she was treated with an increased dose of azathioprine and a slowly tapering prednisone regimen. " 11/01/1992 - "The two patients with Churg Strauss syndrome required azathioprine in addition to long-term prednisolone. " 11/03/2000 - "DIAGNOSIS, TREATMENT AND COURSE: In view of the good therapeutic effects 9 years ago, this relapse of Churg-Strauss syndrome with eosinophilic myocarditis was again treated with azathioprine and steroids. " Order ALL the reference details at left...
8.	rituximab (Mabthera)FDA Link 08/01/2006 - "Successful use of rituximab in a patient with recalcitrant Churg-Strauss syndrome." 04/01/2006 - "Rituximab in Churg-Strauss syndrome." 05/01/2008 - "METHODS: In the present study, rituximab (4 weekly doses of 375 mg/m2 and 2 more doses at 1-month interval) was intravenously administered as a rescue therapy to 7 patients (4 affected by idiopathic systemic microscopic polyangiitis, 2 by Wegener's granulomatosis, and 1 affected by Churg Strauss syndrome). " 04/01/2009 - "Severe bronchospasm associated with rituximab for refractory Churg-Strauss syndrome." 07/01/2008 - "Rituximab is effective in the treatment of refractory Churg-Strauss syndrome and is associated with diminished T-cell interleukin-5 production." Order ALL the reference details at left...
9.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2004 - "Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment." 01/01/2004 - "OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS). " 05/01/2008 - "METHODS: In a prospective open-label trial, seven patients with Churg-Strauss syndrome refractory to cyclophosphamide or methotrexate received interferon-alpha (3 million. " 06/01/2009 - "However, additional immunosuppressive agents are required for other forms of vasculitis: methotrexate in Takayasu's arteritis and non-renal small-vessel vasculitis and cyclophosphamide for classic Wegener's granulomatosis, microscopic polyangiitis, polyarteritis nodosa and Churg-Strauss syndrome with poor prognostic features. " Order ALL the reference details at left...
10.	SteroidsIBA 05/01/2007 - "CONCLUSIONS: Churg-Strauss syndrome may rarely involve the conjunctiva, and conjunctival lesions respond favorably to topical steroids." 12/01/2008 - "Treatment of Churg-Strauss syndrome with an inhaled corticosteroid after oral steroids discontinuation due to side effects." 05/01/2007 - "Topical steroids in the management of Churg-Strauss syndrome involving the conjunctiva." 07/04/1998 - "Steroids and Churg-Strauss syndrome." 10/01/1997 - "A 40-yr-old man who had a known diagnosis of allergic granulomatous angitis (Churg-Strauss syndrome) and had been on steroids was found to have a stone in the common bile duct. " Order ALL the reference details at left...

Therapies and Procedures

1.	Remission Induction 06/01/2007 - "Treatment for Churg-Strauss syndrome: induction of remission and efficacy of intravenous immunoglobulin therapy." 05/01/2008 - "CONCLUSION: Interferon-alpha appears to be an effective and well-tolerated treatment for induction of remission in patients with refractory Churg-Strauss syndrome." 05/01/2008 - "This study was carried out to examine the safety and efficacy of interferon-alpha for induction of remission in patients with refractory Churg-Strauss syndrome. " 01/01/2004 - "Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment." 01/01/2004 - "OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS). " Order ALL the reference details at left...
2.	Plasmapheresis 05/01/1985 - "In the case report the typical symptoms of Churg-Strauss syndrome, the therapeutic possibilities (immunosuppression, plasmapheresis) and the differential diagnosis are discussed." 12/01/2004 - "CONCLUSION: Complete clinical and functional recovery with a long term stable remission and a low incidence of side effects can be achieved by intravenous immunoglobulin associated with plasmapheresis in patients with Churg-Strauss syndrome." 12/01/2004 - "OBJECTIVE: To study the long term effectiveness of intravenous immunoglobulin and plasmapheresis associated with prednisone and cyclophosphamide in Churg-Strauss syndrome. " Order ALL the reference details at left...
3.	Plasma Exchange 11/01/1995 - "To define the most effective treatment for severe polyarteritis nodosa (PAN) and Churg-Strauss syndrome (CSS) and to investigate the indication for plasma exchange treatment. " 09/01/1995 - "Churg-Strauss syndrome with peripheral polyneuropathy refractory to steroideal and immunosuppressive therapy successfully treated with plasma exchange." 12/01/1994 - "Treatment of polyarteritis nodosa and Churg-Strauss syndrome: indications of plasma exchanges." 04/01/2003 - "In polyarteritis nodosa without HBV infection, Wegener's granulomatosis, Churg-Strauss syndrome and in other systemic diseases vasculitides, plasma exchanges can help to control or attenuate the disease. " 02/01/1992 - "Lack of superiority of steroids plus plasma exchange to steroids alone in the treatment of polyarteritis nodosa and Churg-Strauss syndrome. " Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 09/01/2005 - "Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patients." 08/01/2005 - "Leucoencephalopathy after treatment of Churg-Strauss syndrome with interferon {alpha}." 02/20/2002 - "[Churg-Strauss syndrome after treatment with Singulair (montelukast)]" Order ALL the reference details at left...
5.	Transplants (Transplant) 07/01/2006 - "Successful identical-twin living donor small bowel transplant for necrotizing enterovasculitis secondary to Churg-Strauss syndrome." 12/01/1995 - "Two of the hearts examined were explants from heart transplant recipients with hypersensitivity myocarditis at the time of transplant and the third was from an autopsied patient with Churg-Strauss syndrome. " Order ALL the reference details at left...

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