Abstract | BACKGROUND: METHODS: RESULTS: AdipoR1 and AdipoR2 mRNA and protein were expressed by both RASF and OASF. Compared with OASF, RASF exhibited higher levels of AdipoR1, but there was no significant difference for AdipoR2. Adiponectin induced the production of PGE(2) by the synovial fibroblasts in a concentration-dependent manner, and this was more obvious in RASF. RNA interference showed that the difference may be mediated by the diverse distribution of AdipoR1. The adiponectin-induced PGE(2) production was efficiently relieved by the NSAID and COX-2-selective inhibitor. CONCLUSION: The present findings suggest that AdipoR1 may mediate the difference in adiponectin-induced PGE(2) production in RASF and OASF.
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Authors | Wei Zuo, Zhi-Hong Wu, Nan Wu, Yuan-Hui Duan, Ju-Tai Wu, Hai Wang, Gui-Xing Qiu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 124
Issue 23
Pg. 3919-24
(Dec 2011)
ISSN: 2542-5641 [Electronic] China |
PMID | 22340319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADIPOR1 protein, human
- ADIPOR2 protein, human
- Adiponectin
- RNA, Small Interfering
- Receptors, Adiponectin
- Dinoprostone
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Topics |
- Adiponectin
(pharmacology)
- Arthritis, Rheumatoid
(metabolism)
- Blotting, Western
- Cells, Cultured
- Dinoprostone
(metabolism)
- Female
- Fibroblasts
(drug effects, metabolism)
- Humans
- Immunoassay
- Male
- Microscopy, Fluorescence
- Middle Aged
- Osteoarthritis
(metabolism)
- RNA, Small Interfering
- Real-Time Polymerase Chain Reaction
- Receptors, Adiponectin
(genetics, metabolism)
- Synovial Membrane
(cytology)
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