Prostaglandins E
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Networked: 2673
relevant articles (84 outcomes,
355 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Narumiya, Shuh:
19 articles
(07/2012 - 01/2002)
|
2. | Sugimoto, Yukihiko:
14 articles
(07/2012 - 01/2002)
|
3. | Peters-Golden, Marc:
13 articles
(12/2012 - 06/2003)
|
4. | DuBois, Raymond N:
13 articles
(01/2012 - 09/2004)
|
5. | Maruyama, Takayuki:
13 articles
(08/2011 - 01/2002)
|
6. | Jakobsson, Per-Johan:
12 articles
(12/2019 - 07/2003)
|
7. | Akira, Shizuo:
11 articles
(02/2013 - 06/2002)
|
8. | Dannenberg, Andrew J:
11 articles
(04/2012 - 08/2003)
|
9. | Oshima, Hiroko:
10 articles
(03/2013 - 08/2003)
|
10. | Oshima, Masanobu:
10 articles
(03/2013 - 08/2003)
|
Related Diseases
1. | Neoplasms (Cancer)
|
2. | Inflammation (Inflammations)
|
3. | Pain (Aches)
|
4. | Edema (Dropsy)
06/01/2012
- " Further more, the ELISA results showed that CPZ (170, 85, and 42.5 mg/kg for rats, p.o.) could up-regulate the level of IL-1β in the edema paw tissue of rats significantly while down-regulate that of PGE(2), but no apparent effect on TNF-α or NO was observed in the test. " 03/24/2011
- " In addition, we determined the levels of PGE(2) in the edema paw. " 11/01/2009
- " Analysis of the skin 6 h after TPA treatment showed that the TPA-induced promotion of skin edema, inflammatory leukocyte infiltration, COX-2 expression and PGE(2) production was significantly lower in the skin of the IL-12-KO mice than their wild-type counterparts. " 09/15/2003
- " These results suggest that COX-2, but not COX-1, contributes to the edema and the formation of PGE(2) and TXB(2) in mouse CIA model." 02/07/2003
- " The developing edema was measured hourly after CG injection, and the groups injected with PGE(2) 30 and 60 min before CG, presented significant edema potentiation. "
|
5. | Carcinogenesis
|
|
Related Drugs and Biologics
Related Therapies and Procedures