Arthritis (Polyarthritis)

1.	Pain (Aches)
2.	Rheumatoid Arthritis
3.	Inflammation
4.	Arthritis (Polyarthritis)
5.	Experimental Arthritis
923 Diseases and 6127 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Holmdahl, Rikard: 29 articles (12/2007 - 05/2002)
2.	van den Berg, Wim B: 15 articles (04/2008 - 05/2002)
3.	Glant, Tibor T: 14 articles (03/2007 - 01/2002)
4.	Nandakumar, Kutty Selva: 13 articles (10/2007 - 08/2003)
5.	van den Berg, W B: 13 articles (12/2007 - 03/2000)
6.	Finnegan, Alison: 12 articles (04/2008 - 01/2002)
7.	Mikecz, Katalin: 11 articles (12/2006 - 01/2002)
8.	Tarkowski, A: 11 articles (03/2008 - 02/2000)
9.	Schett, Georg: 11 articles (01/2008 - 01/2003)
10.	Veihelmann, A: 10 articles (10/2007 - 06/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arthritis:

1.	Collagen Type II (Type II Collagen)IBA 08/01/2006 - "In the type II collagen-induced arthritis model, we observed a significant reduction in clinical scores (p < 0.01) in three independent experiments and diminished joint pathology (p < 0.005) in PKC-theta-deficient compared with wild-type littermates" 01/01/2000 - "Compound 19a (ED40 = 3.6 mg/kg in established AA) possessed good therapeutic efficacy against type II collagen-induced arthritis in DBA/1J mice with doses of 30 and 100 mg/kg, suggesting the development of 19a (designated T-614) as a prospective disease-modifying antirheumatic agent" 06/01/1985 - "Despite no difference in clearance of anti-type II collagen antibody after transfer between them, the passively transferred arthritis in rnu/rnu rats was significantly enhanced and prolonged in comparison with that in rnu/+ rats" 07/25/2002 - "CONCLUSION: Gene therapy of IL-ira via non-virus eukaryotic expression vactor, especially by gene gun, is effective in treating arthritis induced by type II collagen." 03/01/2006 - "In this study, water extract of deer antler extract (DAA) prepared from the growing antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe was used to investigate the efficacy of the DAA on the development of type II collagen (CII)-induced arthritis (CIA) in rats" Get all the results and reference details, order at left...
2.	AntigensIBA 04/01/1997 - "Animals treated with manipulation and exercise improved significantly relative to untreated animals with antigen-induced arthritis in vertical ankle lift, ankle-based and foot-based stride lengths, knee circumference, and normalized extension of the ankle" 04/01/1980 - "The lymphocyte stimulation induced by gonococcal antigen was significantly greater in patients with postgonorrhoeal arthritis than in healthy controls" 06/10/2001 - "Thus, we demonstrated that (1) a low-dose intraarticular injection of Adex1CACTLA4IgG was effective in delaying the onset of CIA and reducing the severity of arthritis; (2) an intraarticular (knee joint) injection of Adex1CACTLA4IgG effectively blocked the development of arthritis in distal paws; (3) the inhibitory effect of Adex1CACTLA4IgG lasted at least up to 20 weeks; (4) although serum CTLA4IgG at more than 10 microg/ml persisted for at least 12 weeks, mice treated by intraarticular injection of Adex1CACTLA4IgG were not anergic to adenovirus and were able to mount antibody responses against various antigens." 10/01/2002 - "The scFv TS-A12/22 was tested in a rat model of antigen-induced arthritis and proved to be effective in preventing influx of polymorphonuclear cells into the knee joint and C9 deposition on synovial tissue." 04/01/1988 - "The efficacy of therapeutic doses of 32P as a medical synovectomy and its effect on rabbit joints with antigen-induced arthritis were observed in 62 arthritic knee joints in 31 adult rabbits treated on one side with 0.1 microCi of 32P, the opposite serving as control" Get all the results and reference details, order at left...
3.	Methotrexate (Mexate)FDA LinkGeneric 03/01/1993 - "Liposomal methotrexate suppressed the development of arthritis at a dose one-tenth that of the free drug and it was also effective in suppressing arthritis of 7 days duration, although significant beneficial effects of liposomal methotrexate were delayed for 10 to 14 days after injection" 08/01/2000 - "The use of low-dose oral methotrexate (MTX) for persistent polyarthritis has been shown to be effective by the USA/USSR collaborative study group" 02/01/1998 - "CONCLUSION: Methotrexate appears to be effective in the treatment of antimalarial resistant lupus arthritis and is well tolerated." 11/01/1995 - "Methotrexate has been reported to be effective in various animal models of arthritis as well as a variety of human disorders without a shared pathogenesis" 04/01/2008 - "For the total cohort, the remission was longer for wrist and finger joints [risk ratio (RR): 0.2], with concomitant treatment with methotrexate (RR: 0.28) and for enthesitis-related arthritis (RR: 0.34)" Get all the results and reference details, order at left...
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/01/2005 - "CONCLUSION: Cross-sectional observations from an outpatient arthritis clinic found a significantly higher remission rate in patients with RA taking a TNF-alpha inhibitor compared to non-users." 03/01/1998 - "Serum levels of TNF alpha in rats that develop arthritis are significantly greater (2.4 fold) than levels from the other groups" 12/15/2000 - "When treatment was initiated after onset of arthritis, anti-TNF-alpha, anti-IL-1beta, and anti-IL-1R (which blocks IL-1alpha and IL-1beta) were all found to be effective in reducing the severity of arthritis, with anti-IL-1R and anti-IL-1beta showing greater efficacy than anti-TNF-alpha" 05/01/2005 - "Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models." 03/29/1994 - "In contrast, we have recently shown that anti-tumor necrosis factor alpha/beta (TNF) treatment reduces the severity of established arthritis" Get all the results and reference details, order at left...
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/2007 - "The data that have accumulated in recent years underscore the importance of carefully weighing the risks and benefits of traditional NSAIDs and COX-2 selective inhibitors before making therapeutic decisions for the management of chronic arthritis" 05/01/1999 - "BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury" 01/01/1989 - "Non-steroidal anti-inflammatory drugs (NSAIDs) are effective in relieving the symptoms of arthritis, but may have serious side-effects such as gastrointestinal lesions" 07/01/2007 - "The aim of this study was to assess the upper gastrointestinal (GI) harms of the long-term use of COX-2s, compared with nonselective NSAIDs and placebo, in arthritis sufferers" 01/01/2006 - "Resolution of this problem requires several different types of studies, necessarily including appropriately designed randomized, controlled trials comparing commonly employed nonselective and COX-2 selective NSAIDs in patients expected to benefit (ie, those with symptomatically severe arthritis) who also have coronary occlusive disease so that achievable noninferiority trial size has power sufficient to resolve relatively small differences in adverse CV (and gastrointestinal) event rates" Get all the results and reference details, order at left...
6.	CollagenIBA 01/01/1989 - "However, administration of anti-CD8 mAb two weeks after pre-immunization with soluble collagen was very effective in reversing arthritis resistance" 11/01/2007 - "Blood neutrophils from arthritis patients in remission existed in a primed state as revealed by more rapid oxidative response after collagen-bead challenge and a more pronounced response after fMLF stimulation compared to healthy blood donors" 09/01/2004 - "The present study tested the hypothesis that introduction of the same amino acid substitutions into full-length CII might improve the efficacy of the mutant collagen in achieving suppression of autoimmune arthritis" 01/01/2006 - "Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice." 06/01/1993 - "Pinealectomy ameliorates collagen II-induced arthritis in mice." Get all the results and reference details, order at left...
7.	infliximab (Remicade)FDA Link 07/01/2007 - "Infliximab, a chimeric anti-TNFalpha monoclonal antibody, has initially been introduced to Japan in 2003 and shown to be dramatically effective in alleviating arthritis refractory to conventional treatment" 01/01/2006 - "Efficacy of interferon-alpha-2a has also been reported for mucocutaneous lesions, arthritis, and (more anecdotally) for neuro-Behçet, while results from small case series suggest that infliximab is beneficial for mucocutaneous lesions and (more anecdotally) for arthritis and gastro-intestinal manifestations" 11/01/2005 - "CONCLUSIONS: Our study provides further evidence that blocking TNFalpha by infliximab is a powerful tool in the management of chronic arthritis" 10/01/2004 - "All 3 patients with joint involvement experienced remission of arthritis, which relapsed 8-11 weeks after the last infliximab infusion" 02/01/2007 - "The concomitant onset of polyarthritis in three cases raises the need to investigate the incidence of autoimmune manifestations in psoriatic patients receiving infliximab in further large-scale studies." Get all the results and reference details, order at left...
8.	Antirheumatic Agents (DMARD)IBA 06/01/1986 - "MTX is an effective agent for the treatment of inflammatory arthritis in patients who do not respond to therapy with nonsteroidal anti-inflammatory drugs or slow-acting antirheumatic drugs" 04/13/2006 - "This early arthritis clinic model helped to shorten the referral lag time (duration between symptoms onset and first rheumatologist assessment) as well as lag time to DMARD therapy (duration between symptom onset and the institution of DMARD therapy)." 11/01/2003 - "CONCLUSION: Undifferentiated arthritis of the hands is not a benign condition, with 30% of patients receiving DMARD therapy by 12 months and low remission rates" 01/01/2000 - "CONCLUSION: E-alpha1PI complex levels, measured as an index of neutrophil activation, did not correlate with improvement in disease activity in inflammatory arthritis afforded by DMARD." 04/01/2007 - "In preparation for randomised controlled trials (RCTs) of disease-modifying antirheumatic drugs in patients with early inflammatory arthritis (EIA), formative research was conducted to enhance the design of such trials" Get all the results and reference details, order at left...
9.	celecoxib (Celebrex)FDA Link 01/01/2007 - "CONCLUSION: Celecoxib-loaded SLN with its greater intra-articular retention and sustained-release properties would be a beneficial delivery system for the effective treatment of arthritis and is expected to result in prolonged anti-arthritic activity of celecoxib." 04/01/1999 - "The arthritis trials identified celecoxib doses that were effective in treating OA and RA and that were distinguished from placebo on standard arthritis scales" 01/01/1999 - "The arthritis trials identified celecoxib doses that were effective in treating OA and RA and that were distinguished from placebo on standard arthritis scales" 09/01/1998 - "RESULTS: The 2 arthritis trials identified SC-58635 dosage levels that were consistently effective in treating the signs and symptoms of arthritis and were distinguished from placebo on standard arthritis scales" 04/22/2008 - "METHODS AND RESULTS: We performed a patient-level pooled analysis of adjudicated data from 7950 patients in 6 placebo-controlled trials comparing celecoxib with placebo for conditions other than arthritis with a planned follow-up of at least 3 years" Get all the results and reference details, order at left...
10.	TNFR-Fc fusion protein (etanercept)FDA Link 01/01/2003 - "In conclusion, etanercept has emerged as an important new treatment option in inflammatory arthritis" 01/01/2002 - "In conclusion, etanercept has emerged as an important new treatment option in inflammatory arthritis" 11/01/2002 - "In a phase 2, randomized, placebo-controlled trial of 60 patients with PsA, etanercept 25 mg subcutaneously twice weekly resulted in significantly more improvement in arthritis and skin symptoms than placebo" 12/01/2005 - "The symptoms of arthritis improved significantly except that the patient with systemic JRA had disease flare-up during etanercept therapy" 05/01/2002 - "CONCLUSION: In this initial study of etanercept therapy for Still's disease in the adult, this treatment resulted in improvement in the arthritis and was well tolerated" Get all the results and reference details, order at left...
2745 Drugs and Important Bio-Agents and 12425 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Arthroplasty 09/01/2006 - "Total knee arthroplasty (TKA) is a well-established procedure, and has proven to be durable and effective for the treatment of advanced arthritis of the knee joint" 04/01/2006 - "Total joint arthroplasty is very effective for improving the quality of life of patients with end-stage arthritis" 10/01/1996 - "Open partial trapeziectomy and interpositional arthroplasty have proven to be effective in ameliorating the symptoms of carpometacarpal joint arthritis of the thumb" 10/01/2008 - "Significant improvement can be obtained when revising the failed patellofemoral arthroplasty, provided there is no femorotibial arthritis." 08/01/2003 - "CONCLUSIONS: This investigation documented the good results obtainable with shoulder arthroplasty for the treatment of arthritis following anterior shoulder instability" Get all the results and reference details, order at left...
2.	Arthrodesis 09/01/2004 - "Arthrodesis remains the mainstay of treatment of end-stage arthritis of the foot and ankle" 01/01/1998 - "We conclude that isolated subtalar arthrodesis with internal compression was effective treatment for post-traumatic subtalar arthritis" 01/01/1991 - "Arthrodesis is a safe and effective way of treating isolated painful arthritis in the trapeziometacarpal joint; solid fusion occurred in 39 cases, and four patients had fibrous union" 10/01/1998 - "BACKGROUND: The purpose of this study was to evaluate prospectively the efficacy of subtalar distractional realignment arthrodesis in the treatment of calcaneal malunion associated with subtalar arthritis, collapse of height, talonavicular subluxation, malalignment of the heel axis, and widening heel with calcaneofibular abutment" 09/01/2008 - "Ankle arthrodesis remains the gold standard of surgical treatment for advanced ankle joint arthritis" Get all the results and reference details, order at left...
3.	Osteotomy 01/01/2003 - "The results of this study suggest that high tibial osteotomy alone and combined high tibial osteotomy/ACL reconstructions are effective in the surgical treatment of varus, ACL-deficient knees with symptomatic medial compartment arthritis; however, good or excellent results were more often seen after the combined procedure." 01/01/1998 - "This long-term review revealed that, with strict adherence to the surgical principles of obtaining and maintaining proper alignment, proximal tibial osteotomy for unicompartmental arthritis can result in good function and symptomatic relief for an average of ten to 14 years." 07/01/2008 - "PURPOSE: The purpose of our study was to evaluate the complications, technique-related risks, and the clinical course of patients treated with high tibial osteotomy (HTO) for medial arthritis of the knee with varus malalignment" 03/01/2007 - "Further studies will continue to clarify the role and indications for osteotomies for treatment of ankle arthritis." 03/01/2006 - "The purpose of the present study was to evaluate the outcome after distal femoral osteotomy performed for the treatment of painful genu valgum and to assess the influence of patellofemoral arthritis on the results" Get all the results and reference details, order at left...
4.	Drug Therapy (Chemotherapy) 05/01/1976 - "Type of drug therapy tended to reflect severity of arthritis, rather than vice versa, and functional capacity improved significantly from entry to last evaluation in both males and females, even though the latter had stable or progressive arthritis" 06/01/1984 - "The ability to recall details of current and prior drug therapy was evaluated in two studies employing a total of 94 patients with inflammatory polyarthritis" 01/01/2008 - "The review of state-of-the-art stage of pharmacotherapy of juvenile arthritis is represented" 01/01/2008 - "State-of-the-art pharmacotherapy of juvenile arthritis]" 10/01/2006 - "METHODS: MR examinations of the wrists and second and third metacarpophalangeal joints were performed using a portable in-office MR system in a total of 405 patients with inflammatory arthritis, from one rheumatologist's practice, who were undergoing aggressive disease modifying antirheumatic drug therapy" Get all the results and reference details, order at left...
5.	Transplants (Transplant) 08/01/1988 - "In treating established nonunions without arthritis, the Russe bone graft technique is the mainstay of treatment" 07/01/2002 - "BMT alone did not cure lupus with polyarthritis in MRL/lpr mice or polyarthritis in NZB/KN mice, but BMT plus bone (stromal cell) transplants cured these diseases" 02/01/2002 - "The authors successfully treated two cases of wrist arthritis severely infected by Staphylococcus aureus and Mycobacterium tuberculosis with vascularized fibular osteocutaneous grafts" 02/01/2002 - "Vascularized fibular osteocutaneous grafts in the treatment of severely infected wrist arthritis." 01/01/1994 - "The authors have studied the results of a personal technique concerning the treatment of trapezo-metacarpal arthritis: a partial trapezectomy is associated with a antogenous rib cartilage graft" Get all the results and reference details, order at left...
236 Therapies and Procedures and 2099 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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