Abstract | AIM OF THE STUDY: MATERIALS AND METHODS: Gene and protein expression analyses of iNOS and COX-2 were quantified by real time PCR and Western blot analysis and serum levels of IL-4, -5 and -13 were also measured by ELISA, all of which were reduced after treatment with the experimental agent. Additionally, serum concentrations of IgE and blood eosinophil counts were reduced in treated mice. RESULTS: The topical application of leaf and bark extract from Alnus japonica suppressed the development of AD-like skin lesions. The percent of blood eosinophils was decreased after treatment with leaf and bark extract from Alnus japonica. The serum IgE and Th2-related cytokine levels were decreased after treatment with leaf and bark extract from Alnus japonica compared with those treated with base cream (vehicle treated AD group). The IL-4, IL-5 and IL-13 were lower than those of vehicle treated AD group. CONCLUSIONS: We contend that leaf and bark extract from Alnus japonica may prove useful in the treatment of atopic dermatitis and other allergic skin diseases, although more in-depth clinical studies are necessary before clinical implementation.
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Authors | Sun Eun Choi, Kwan Hee Park, Mi Sook Jeong, Han Hyuk Kim, Do Ik Lee, Seong Soo Joo, Chung Soo Lee, Hyoweon Bang, Young Wook Choi, Mi-Kyung Lee, Seong Jun Seo, Min Won Lee |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 136
Issue 3
Pg. 406-13
(Jul 14 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21184819
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Dermatologic Agents
- Immunologic Factors
- Plant Extracts
- Immunoglobulin E
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Topics |
- Alnus
- Animals
- Cytokines
(blood)
- Dermatitis, Atopic
(drug therapy, immunology, pathology)
- Dermatologic Agents
(pharmacology, therapeutic use)
- Disease Models, Animal
- Eosinophils
(metabolism)
- Female
- Immunoglobulin E
(blood)
- Immunologic Factors
(pharmacology, therapeutic use)
- Mice
- Mice, Inbred Strains
- Phytotherapy
- Plant Bark
- Plant Extracts
(pharmacology, therapeutic use)
- Plant Leaves
- Skin
(drug effects, immunology, pathology)
- Th2 Cells
(metabolism)
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