Abstract | BACKGROUND: METHODS: Sixty-two patients with well-controlled type 2 diabetes and an age, gender and body mass index-matched group of 58 healthy individuals were recruited. Serum OPG, RANKL and TRAIL were measured using commercial enzyme-linked immunosorbent assays, as were hsCRP and IL-6. RESULTS: Serum OPG, IL-6 and hsCRP levels, but not RANKL or TRAIL, were higher in patients with type 2 diabetes mellitus than in healthy controls, after adjustment for age and gender. After exclusion of diabetes patients with a history of micro- or macrovascular disease, OPG remained significantly higher in those with diabetes, but IL-6 and hsCRP levels were no longer elevated. There was a positive correlation between OPG and IL-6 in the group as a whole, but no correlation was found between RANKL or TRAIL and either hsCRP or IL-6. CONCLUSION: OPG, but not RANKL or TRAIL, is significantly increased in type 2 diabetes. Higher OPG (but not IL-6 or hsCRP) in those without vascular disease suggests these biomarkers reflect separate pathophysiological processes in the vasculature.
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Authors | Eoin P O'Sullivan, David T Ashley, Colin Davenport, Niamh Devlin, Rachel Crowley, Amar Agha, Christopher J Thompson, Donal O'Gorman, Diarmuid Smith |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 26
Issue 6
Pg. 496-502
(Sep 2010)
ISSN: 1520-7560 [Electronic] England |
PMID | 20809534
(Publication Type: Journal Article)
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Copyright | 2010 John Wiley & Sons, Ltd. |
Chemical References |
- Biomarkers
- Interleukin-6
- Osteoprotegerin
- RANK Ligand
- TNF-Related Apoptosis-Inducing Ligand
- TNFSF10 protein, human
- C-Reactive Protein
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Topics |
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Diabetes Mellitus, Type 2
(blood, complications)
- Diabetic Angiopathies
(blood)
- Female
- Humans
- Inflammation
(blood)
- Interleukin-6
(blood)
- Male
- Middle Aged
- Osteoprotegerin
(metabolism)
- RANK Ligand
(blood)
- TNF-Related Apoptosis-Inducing Ligand
(blood)
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