Abstract | AIMS/HYPOTHESIS: METHODS: RESULTS: In general, the genes studied were downregulated after weight loss intervention. The changes in TLR4, TLR2, CCL5 and TNFRSF1A mRNA expression were associated with an increase in insulin sensitivity index independently of the change in waist circumference (p < 0.05). The change in IKBKB expression correlated with most of the changes in gene expression in the weight-reduction group. CONCLUSIONS/INTERPRETATION: TRIAL REGISTRATION: ClinicalTrials.gov NCT 00621205.
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Authors | V D F de Mello, M Kolehmainen, L Pulkkinen, U Schwab, U Mager, D E Laaksonen, L Niskanen, H Gylling, M Atalay, R Rauramaa, M Uusitupa |
Journal | Diabetologia
(Diabetologia)
Vol. 51
Issue 11
Pg. 2060-7
(Nov 2008)
ISSN: 0012-186X [Print] Germany |
PMID | 18758745
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCL5 protein, human
- Chemokine CCL5
- NF-kappa B
- Receptors, Tumor Necrosis Factor, Type I
- TLR2 protein, human
- TLR4 protein, human
- TNFRSF1A protein, human
- Toll-Like Receptor 2
- Toll-Like Receptor 4
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Topics |
- Adult
- Aged
- Body Mass Index
- Chemokine CCL5
(genetics)
- Down-Regulation
- Glucose Intolerance
- Humans
- Metabolic Syndrome
(genetics, physiopathology)
- Middle Aged
- NF-kappa B
(physiology)
- Obesity
(genetics)
- Overweight
(genetics)
- Randomized Controlled Trials as Topic
- Receptors, Tumor Necrosis Factor, Type I
(genetics)
- Toll-Like Receptor 2
(genetics)
- Toll-Like Receptor 4
(genetics)
- Weight Loss
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