Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review.
Abstract | OBJECTIVE: DATA SOURCES: English-language literature cited in MEDLINE from January 1, 1968, to December 31, 2005, was searched with the keywords anxiety disorder, anxiety symptoms, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, posttraumatic stress disorder, social phobia, bipolar disorder, major depressive disorder, Hamilton Rating Scale for Anxiety, antipsychotics, typical antipsychotics, atypical antipsychotics, fluphenazine, haloperidol, perphenazine, pimozide, thiothixene, trifluoperazine, loxapine, molindone, chlorpromazine, mesoridazine, thioridazine, fluspirilene, penfluridol, pipothiazine, flupenthixol, clozapine, olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole, amisulpride, and clinical trial. Randomized, double-blind, placebo-controlled trials and open-label studies with a minimum of 20 subjects with a DSM-III/IV or ICD-10 diagnosis of anxiety disorder and studies without a DSM-III/IV or ICD-10 diagnosis of anxiety disorder but with Hamilton Rating Scale for Anxiety (HAM-A) scores as an outcome were prioritized. Studies on bipolar disorder or major depressive disorder with the analysis of changes in anxiety symptoms were reviewed. Early studies on neurosis/ anxiety or anxious depression without a HAM-A component were also reviewed. DATA SYNTHESIS: CONCLUSION: Except for trifluoperazine, there is no large, well-designed study of antipsychotics in the treatment of primary or comorbid anxiety symptoms or disorders. The efficacy of these agents in various anxiety conditions needs to be further investigated with large, well-designed comparison studies.
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Authors | Keming Gao, David Muzina, Prashant Gajwani, Joseph R Calabrese |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 67
Issue 9
Pg. 1327-40
(Sep 2006)
ISSN: 0160-6689 [Print] United States |
PMID | 17017818
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Antipsychotic Agents
- Placebos
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Topics |
- Affective Symptoms
(diagnosis, drug therapy, epidemiology)
- Antipsychotic Agents
(classification, therapeutic use)
- Anxiety Disorders
(diagnosis, drug therapy, epidemiology)
- Bipolar Disorder
(diagnosis, drug therapy, epidemiology)
- Comorbidity
- Depressive Disorder, Major
(diagnosis, drug therapy, epidemiology)
- Diagnostic and Statistical Manual of Mental Disorders
- Double-Blind Method
- Humans
- International Classification of Diseases
- Longitudinal Studies
- MEDLINE
(statistics & numerical data)
- Placebos
- Psychiatric Status Rating Scales
- Randomized Controlled Trials as Topic
- Treatment Outcome
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