Clozapine (Clozaril)

Subscribe to Selected New Research on Clozapine

3081 relevant articles (357 outcomes, 536 trials/studies) found for this Drug

Description: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Also Known As:

Clozaril; Leponex; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25

3-Ring Heterocyclic Compounds

Dibenzazepines

Clozapine: 3081

norclozapine: 31

clozapine N-oxide: 12

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine: 1

2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine: 1

clozapine N-glucuronide

Experts

1.	Meltzer, Herbert Y: 15 articles (10/2008 - 08/2002)
2.	Lieberman, Jeffrey A: 10 articles (10/2008 - 02/2002)
3.	Green, Alan I: 7 articles (09/2008 - 08/2002)
4.	Kane, John M: 7 articles (08/2008 - 05/2002)
5.	Duggal, Harpreet S: 7 articles (10/2007 - 02/2002)
6.	Sheitman, Brian: 7 articles (10/2007 - 02/2002)
7.	Volavka, Jan: 7 articles (08/2005 - 02/2002)
8.	Rapoport, Judith L: 6 articles (10/2007 - 01/2002)
9.	Henderson, David C: 6 articles (09/2007 - 05/2003)
10.	Remschmidt, H: 6 articles (08/2007 - 05/2001)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/01/2007 - "The study of anatomic and functional brain variables associated with clozapine response in schizophrenia may help to identify patients who are most likely to benefit from clozapine treatment. " 01/01/1992 - "Clinical studies have shown clozapine to be effective in the treatment of schizophrenia and associated with an extremely low incidence of extrapiramidal side effects. " 11/01/1990 - "Clinical studies have shown clozapine to be effective in suppressing both the positive and negative symptoms of schizophrenia and to be associated with an extremely low incidence of extrapyramidal side effects. " 10/01/2009 - "OBJECTIVE: Clozapine, a dibenzodiazepine antipsychotic, is the most effective medication for treatment-resistant schizophrenia. " 09/01/2007 - "It then discusses the definition and treatment of treatment-resistant schizophrenia, with particular attention to clinical, biological and neuroimaging correlates, as well as the best treatment options, including the use of clozapine in patients who meet the definition of treatment-resistant schizophrenia." Order ALL the reference details at left...
2.	Dyskinesias (Dyskinesia) 10/01/1984 - "With this in mind, the authors present the case of a 32-year-old chronically institutionalized schizophrenic who showed a remarkable improvement in both tardive dyskinesia and psychotic symptoms following an open trial of clozapine, 900 mg daily. " 07/01/1994 - "We conclude that clozapine is an effective agent for suppression of dyskinesias in PD with an effective daily dose for most patients of 100-200 mg/day." 01/01/1994 - "Clozapine, the best studied of these agents, is also superior in efficacy with regard to psychopathology and cognitive function and has been shown not to cause tardive dyskinesia. " 09/01/1993 - "With the advent of clozapine, patients with preexisting tardive dyskinesia began therapy and their symptoms did not worsen--and, in many cases, their symptoms improved dramatically. " 03/01/1996 - "Sixteen months of clozapine treatment led to significant reduction of symptomatology with marked improvement in social functioning and diminished tardive dyskinesia. " Order ALL the reference details at left...
3.	Psychotic Disorders (Schizoaffective Disorder) 08/01/1997 - "The atypical antipsychotic clozapine has been reported to be effective in otherwise refractory psychoses. " 04/01/1995 - "CONCLUSIONS: Clozapine was an effective treatment for refractory psychotic disorders when given as a part of routine state hospital treatment." 01/01/2002 - "Clozapine has shown consistent efficacy against positive symptoms of psychoses, and emerging reports indicate improvements in aggression and suicidality. " 05/01/1994 - "Advances in the nosology of schizoaffective disorder, emerging epidemiologic data demonstrating large numbers of patients with this disorder in clinical populations, and preliminary evidence that clozapine may have combined antipsychotic and thymoleptic properties as well as efficacy in both the psychotic and affective components of schizoaffective disorder, suggest that renewed interest in the diagnosis and treatment of this disorder may lead to improved delivery of care for this understudied but seriously ill group of patients." 01/01/2002 - "This case series underlines the safety and efficacy of clozapine as add-on medication in the treatment of bipolar and schizoaffective disorders." Order ALL the reference details at left...
4.	Bipolar Disorder (Mania) 08/01/2004 - "CONCLUSIONS: Clozapine is more effective in NRC patients with a history of mania in comparison to patients with a recent history of RC." 06/01/2000 - "CONCLUSIONS: The findings from this open-label study, which are consistent with previous retrospective studies, case reports, and one other open-label prospective study, suggest that clozapine is an effective agent for patients with treatment-refractory psychotic mania." 01/01/2002 - "Clozapine, an atypical antipsychotic, has been reported to be effective in adults with treatment-resistant bipolar disorder. " 06/01/1999 - "BACKGROUND: Clozapine may be effective in adults and adolescents with treatment-resistant bipolar disorder. " 03/01/1995 - "BACKGROUND: Clozapine has been increasingly shown to be effective in the acute and maintenance treatment of bipolar disorders. " Order ALL the reference details at left...
5.	Agranulocytosis (Granulocytopenia) 03/01/1995 - "Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop." 09/01/1999 - "The atypical antipsychotic agent clozapine is known to be effective in schizophrenic patients refractory to other medications; however, it induces agranulocytosis in approximately 1-2%. " 09/14/2006 - "Thus functional data derived from the in vitro stromal system defined in these studies may enable further investigation of the mechanisms subserving stromal impairment in clozapine-induced agranulocytosis and direct attention to improved methods for its prevention." 09/01/1994 - "Due to the risk of agranulocytosis, clozapine cannot yet be considered a first-choice treatment for psychotic symptoms, but many studies indicate it to be helpful with a wide variety of treatment-resistant ones." 12/01/1996 - "Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Risperidone (Risperdal Consta)
3.	olanzapine (Zyprexa)
4.	Haloperidol (Haldol)
5.	quetiapine (Seroquel)
6.	Levodopa (L Dopa)
7.	Lithium
8.	ziprasidone (Geodon)
9.	Chlorpromazine (Thorazine)
10.	Clozapine (Clozaril)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Injections
4.	Withholding Treatment
5.	Hemoperfusion

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