Antipsychotic Agents (Antipsychotics)

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6981 relevant articles (665 outcomes, 1047 trials/studies) found for this Bio-Agent

Description: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in schizophrenia, senile dementia, transient psychosis following surgery or myocardial infarction, etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Also Known As:

Antipsychotics; Antipsychotic Drugs; Neuroleptics; Major Tranquilizers; Neuroleptic Agents; Neuroleptic Drugs; Tranquillizing Agents, Major; Agents, Antipsychotic; Agents, Major Tranquilizing; Agents, Major Tranquillizing; Agents, Neuroleptic; Drugs, Antipsychotic; Drugs, Neuroleptic; Major Tranquilizing Agents; Major Tranquillizing Agents; Tranquilizers, Major; Tranquilizing Agents, Major

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses

Pharmacologic Actions: 50

Therapeutic Uses: 189

Central Nervous System Agents: 17

Psychotropic Drugs: 1045

Tranquilizing Agents: 50

Antipsychotic Agents: 6981

Central Nervous System Depressants: 69

Tranquilizing Agents: 50

Antipsychotic Agents: 6981

Physiological Effects of Drugs: 1

Central Nervous System Depressants: 69

Tranquilizing Agents: 50

Antipsychotic Agents: 6981

Experts

1.	Lieberman, Jeffrey A: 9 articles (10/2007 - 02/2003)
2.	Kane, John M: 8 articles (07/2008 - 07/2003)
3.	Kinon, Bruce J: 8 articles (07/2008 - 04/2003)
4.	Ascher-Svanum, Haya: 8 articles (07/2008 - 01/2004)
5.	Citrome, Leslie: 8 articles (07/2008 - 02/2003)
6.	Jeste, Dilip V: 8 articles (04/2008 - 03/2002)
7.	Meltzer, Herbert Y: 8 articles (10/2007 - 02/2003)
8.	Correll, Christoph U: 7 articles (04/2008 - 01/2004)
9.	Henderson, David C: 7 articles (02/2008 - 04/2002)
10.	Leucht, Stefan: 7 articles (11/2007 - 07/2003)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 10/01/2008 - "BACKGROUND: Antipsychotic drugs are the most effective treatment for the psychotic symptoms of schizophrenia, yet their mechanism of action remains largely unknown" 10/15/2007 - "It is important to consider the interactions between nicotinic and antipsychotic drugs to develop the most efficacious treatment for cognitive improvement in people with schizophrenia." 03/01/2006 - "Although antipsychotic drugs are therapeutically effective in attenuating the hallmark symptoms of schizophrenia, these improvements do not return most patients to normative standards of cognitive function" 01/01/2004 - "The most appropriate clinical approach to maximize QoL and subjective wellbeing for patients with schizophrenia is to use atypical antipsychotic drugs as a first-line treatment approach" 09/01/2000 - "Antipsychotic drugs are the most effective medication for the treatment of schizophrenia" Order ALL the reference details at left...
2.	Bipolar Disorder (Mania) 01/01/2005 - "The atypical antipsychotics, with their proven efficacy against manic symptoms, are emerging as candidates for use against the depressive phase of bipolar disorder" 01/01/2005 - "Atypical antipsychotics appear to have broadly similar efficacy against manic symptoms of bipolar disorder, but there are important differences in their tolerability profiles, which are likely to be of particular relevance during long-term treatment" 01/01/2007 - "With mania or mixed presentation atypical antipsychotics produced significantly better rates of response and symptomatic remission than placebo, with NNTs of about 5 up to six weeks, and 4 at 6-12 weeks, but more adverse event withdrawals (NNH of about 22) in studies of 6-12 weeks" 01/01/2005 - "Subgroup analyses from trials treating manic phase bipolar disorder, and an open-label study of rapid cycling, have suggested that atypical antipsychotics may be useful for the treatment of mixed states and rapid cycling" 02/01/2008 - "All atypical antipsychotics caused a significantly greater incidence of somnolence than placebo in mania and depression, with NNTHs from 5 to 8 for mania and 2 to 6 for depression" Order ALL the reference details at left...
3.	Dyskinesias (Dyskinesia) 12/01/1982 - "Ironically, neuroleptics are the most consistently effective treatment of tardive dyskinesia" 01/01/1979 - "Paradoxically, the most effective treatment for suppressing dyskinesia is administration of neuroleptics" 02/01/1999 - "The arrival of atypical antipsychotics has markedly improved the outlook: atypical antipsychotics are emerging as effective treatments and may also reduce the prevalence and incidence of tardive dyskinesia" 08/01/1999 - "Atypical antipsychotic agents would appear to have significant benefits in the treatment of this group of patients, given the particular vulnerability of the elderly to extrapyramidal adverse effects, notably tardive dyskinesia." 04/01/1980 - "The authors also discuss the use of alternative treatment programs and psychosocial interventions that may allow significant reduction in neuroleptics, and they describe new areas of research aimed at preventing and treating tardive dyskinesia." Order ALL the reference details at left...
4.	Psychotic Disorders (Schizoaffective Disorder) 06/01/2003 - "While efficacious, their side-effects have been problematic and the approval by the Food and Drug Administration of the newer antipsychotics with improved side-effects profiles heralded important advances in treating psychoses" 04/01/1991 - "The acute psychoses did not improve with moderate doses of major tranquilizers but resolved completely with drug discontinuation." 10/01/2004 - "The appearance of the atypical antipsychotics has come as a true 'revolution' in their treatment, owing to the good results obtained in the treatment of the psychoses and the scant deterioration of the motor signs of PD." 08/01/1998 - "The existing literature suggests fairly good efficacy of both typical and atypical antipsychotics in the treatment of psychotic disorders in children and adolescents" 04/01/2008 - "BACKGROUND: The second-generation antipsychotics are effective for treating psychotic disorders and incur fewer motor side effects than are commonly experienced with the use of first-generation antipsychotics" Order ALL the reference details at left...
5.	Dementia (Dementias) 04/01/2008 - "BACKGROUND: There have been increasing concerns regarding the safety and efficacy of neuroleptics in people with dementia, but there are very few long-term trials to inform clinical practice" 05/01/2000 - "Traditional neuroleptics have been the mainstay of treatment for agitated behavior in persons with dementia, but these agents have limited efficacy and are associated with high rates of adverse effects, including worsening of already poor cognitive functioning" 04/01/2008 - "Thus, there is insufficient evidence to suggest that psychotropics other than antipsychotics represent an overall effective and safe, let alone better, treatment choice for psychosis or agitation in dementia; currently no such treatment has been approved by the FDA for these symptoms" 05/01/1990 - "Prior qualitative literature reviews about the use of neuroleptics in dementia suggest that they are "modestly effective" in treating agitation and that no single neuroleptic is better than another" 01/01/2008 - "Numerous recent studies have challenged the widely held belief that atypical antipsychotics are safe and effective options for the treatment of behavioural problems such as agitation in patients with dementia" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Risperidone (Risperdal Consta)
2.	Clozapine (Clozaril)
3.	Antipsychotic Agents (Antipsychotics)
4.	olanzapine (Zyprexa)
5.	Antidepressive Agents (Antidepressants)
6.	Lithium
7.	Haloperidol (Haldol)
8.	Dopamine (Intropin)
9.	quetiapine (Seroquel)
10.	ziprasidone (Geodon)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Therapeutics
4.	Withholding Treatment
5.	Transcutaneous Electric Nerve Stimulation (TENS)

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