Abstract | BACKGROUND: CASE REPORT: The patient is a 26-year-old black woman with history of hypertension. She presented to the clinic with blurred vision, headaches, palpitations, weight loss, weakness, and persistent high blood pressure. She was found to have exophthalmus, lid lag, and a symmetric, smooth, and diffuse goiter. Ptosis and diplopia were absent; neurologic examination findings was normal. The patient had positive TPO antibodies, elevated free T4 level, and low thyroid-stimulating hormone (TSH) level. Graves disease was diagnosed and propylthiouracil was prescribed. The patient then returned to the clinic 2 weeks later with weakness and myalgias. Her physical examination findings were unchanged except for mild muscle weakness. Laboratory evaluation showed normal electrolytes, normal renal function, and negative urine drug screening. Creatine phosphokinase was 1276 U/L. Her free T4 and T3 levels were elevated and TSH level was low. The patient was treated with aggressive oral fluid resuscitation. Propylthiouracil was continued and free T4 and T3 normalized along with creatine phosphokinase with resolution of symptoms. CONCLUSIONS:
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Authors | Daniel M Lichtstein, Roque B Arteaga |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 332
Issue 2
Pg. 103-105
(Aug 2006)
ISSN: 0002-9629 [Print] United States |
PMID | 16909061
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antithyroid Agents
- Propylthiouracil
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Topics |
- Adult
- Antithyroid Agents
(administration & dosage)
- Female
- Graves Disease
(blood, complications, diagnosis, diet therapy)
- Humans
- Propylthiouracil
(administration & dosage)
- Remission Induction
- Resuscitation
(methods)
- Rhabdomyolysis
(blood, diagnosis, drug therapy, etiology)
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