Abstract | BACKGROUND: MATERIAL/METHODS: A two phased population-based epidemiological study was undertaken. Phase one evaluated reported NDs to the Vaccine Adverse Event Reporting System (VAERS) following thimerosal-containing Diphtheria- Tetanus-acellular- Pertussis ( DTaP) vaccines in comparison to thimerosal-free DTaP vaccines administered from 1997 through 2001. Phase two evaluated the automated Vaccine Safety Datalink (VSD) for cumulative exposures to mercury from TCVs at 1-, 2-, 3-, and 6-months-of-age for infants born from 1992 through 1997 and the eventual risk of developing NDs. RESULTS: CONCLUSIONS: This study showed that exposure to mercury from TCVs administered in the US was a consistent significant risk factor for the development of NDs. It is clear from these data and other recent publications linking TCVs with NDs that additional ND research should be undertaken in the context of evaluating mercury-associated exposures and thimerosal-free vaccines should be made available.
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Authors | David A Geier, Mark R Geier |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 11
Issue 4
Pg. CR160-70
(Apr 2005)
ISSN: 1234-1010 [Print] United States |
PMID | 15795695
(Publication Type: Journal Article)
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Chemical References |
- Diphtheria Toxoid
- Vaccines
- Thimerosal
- Pertussis Toxin
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Topics |
- Child
- Databases, Factual
- Diphtheria Toxoid
(adverse effects)
- Female
- Fever
(epidemiology)
- Humans
- Male
- Patient Selection
- Pertussis Toxin
(adverse effects)
- Seizures
(epidemiology)
- Thimerosal
(adverse effects)
- Vaccines
(adverse effects, therapeutic use)
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