Tics (Tic)

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1092 relevant articles (88 outcomes, 137 trials/studies) found for this Disease

Description: Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)

Also Known As:

Tic; Motor Tic; Habit Chorea; Habituation Spasm; Tic, Gestural; Tic, Transient; Chorea, Habit; Choreas, Habit; Gestural Tic; Gestural Tics; Habit Choreas; Habit Spasms; Habituation Spasms; Motor Tics; Spasm, Habit; Spasm, Habituation; Spasms, Habit; Spasms, Habituation; Tics, Gestural; Tics, Motor; Tics, Transient; Tics, Vocal; Transient Tic; Transient Tics; Vocal Tic; Vocal Tics; Habit Spasm; Tic, Motor; Tic, Vocal

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3424

Neurologic Manifestations: 2879

Dyskinesias: 5115

Tics: 1092

Signs and Symptoms Pathological Conditions

Signs and Symptoms

Neurologic Manifestations: 2879

Dyskinesias: 5115

Tics: 1092

Related Diseases

1.	Tourette Syndrome (Tourette's Syndrome)
2.	Tics (Tic)
3.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
4.	Tic Disorders (Tic Disorder)
5.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)

Experts

1.	Jankovic, J: 3 articles (01/2007 - 08/2000)
2.	Liu, P: 2 articles (12/2007 - 07/2004)
3.	Takahashi, Y: 2 articles (12/2007 - 07/2004)
4.	Nakamura, K: 2 articles (12/2007 - 07/2004)
5.	Rodriguez, J A: 2 articles (12/2007 - 07/2004)
6.	Melnyk, Patricia: 2 articles (11/2005 - 11/2005)
7.	Sergheraert, Christian: 2 articles (11/2005 - 11/2005)
8.	Girault-Mizzi, Sophie: 2 articles (11/2005 - 11/2005)
9.	Charton, Julie: 2 articles (11/2005 - 11/2005)
10.	Debreu-Fontaine, Marie-Ange: 2 articles (11/2005 - 11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tics:

1.	Haloperidol (Haldol)FDA LinkGeneric 11/01/1985 - "The one patient who was severely bothered by the recurrence of motor and vocal tics responded well to haloperidol" 01/01/1985 - "Haloperidol improved tic symptoms in 50/60 patients, but side effects often nullified these benefits" 12/01/2003 - "When tics are so severe that medication is necessary, haloperidol is no longer the first or only choice" 04/01/1994 - "Haloperidol addition was of little benefit in treating OCD patients without tics" 05/01/1990 - "After haloperidol was discontinued, an exacerbation of tics and the associated behaviors occurred." Order ALL the reference details at left...
2.	Clonidine (ST 155)FDA LinkGeneric 03/01/1994 - "Symptoms of ADHD were treated successfully with clonidine; however, patients experienced persistent tics" 03/01/1993 - "RESULTS: Clonidine treatment resulted in improvement in both the ADHD (39/54; 72%) and tic symptoms (18/24; 75%) groups" 05/01/2001 - "A case study is presented in which clonidine at subclinical concentrations led to an exacerbation of the tics and caused severe systemic heat sensations" 11/01/2000 - "The diagnosis was changed to complex motor tics and the therapy changed to clonidine" 03/01/1996 - "Baseline sitting diastolic blood pressure was directly correlated with measures of tic severity but not with tic response to clonidine" Order ALL the reference details at left...
3.	Botulinum Toxins (Botulinum Toxin)IBA 07/01/1996 - "He was treated with unilateral injections of botulinum toxin to the vocal cord and experienced marked improvement in coprolalia as well as marked reduction in the premonitory urges associated with the vocal tics and coprolalia" 08/01/2000 - "CONCLUSIONS: Botulinum toxin A injections are an effective and well-tolerated treatment of tics" 05/01/1994 - "Botulinum toxin (BTX) injections provide effective treatment for a variety of disorders manifested by inappropriate muscle contractions, but its efficacy in the treatment of tics has not been previously studied" 01/01/2008 - "Botulinum toxin (BnT) appears to be a safe and effective treatment for tics, but some concern exists about which group of patients may benefit from treatment" 03/13/2001 - "BACKGROUND: Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin" Order ALL the reference details at left...
4.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2004 - "Neuroleptics are generally highly effective in suppressing tics, but their many adverse effects limit their usefulness" 01/01/2000 - "Interest in the atypical neuroleptics is understandable, but much more study is needed before these agents can become first-line treatments for tics" 04/01/2004 - "Severity of ADHD symptoms and motor tics were associated significantly and independently with short interval intracortical inhibition (SICI) (r(2) = 0.50; F[2,27] = 13.7; P < 0.001), particularly in subjects not taking neuroleptics (r(2) = 0.68; F[2,17] = 17.8; P < 0.0001)" 08/01/2003 - "When necessary, treatment of tics can be successful with neuroleptics and alpha-2-adrenergic agonists" 02/01/2002 - "Antipsychotic drugs are used to treat a wide variety of child psychiatric disorders characterized by psychotic symptoms, aggression, excitement, tics, stereotypies and hyperactivity nonresponsive to other therapies" Order ALL the reference details at left...
5.	Risperidone (Risperdal Consta)FDA Link 11/01/2006 - "Risperidone is usually the first choice and may have efficacy for behavior problems that often accompany tics" 01/01/2007 - "His score on the Yale Global Tic Severity Scale dropped from 74 at the first assessment to a score of 50 at week 4 of treatment with risperidone 0,5 mg/day and sertralin 25 mg/day" 05/01/2006 - "Risperidone and late onset tics." 04/01/2005 - "Effectiveness and safety of risperidone for children and adolescents with chronic tic or tourette disorders in Korea." 04/08/2003 - "The 12 children randomized to risperidone showed a 36% reduction in tic symptoms compared to an 11% decrease in the 14 children on placebo (F[2,48] = 6.38; p = 0.004)" Order ALL the reference details at left...
6.	Pimozide (Orap)FDA Link 03/10/1999 - "Chronic, longer term treatment with pimozide appears to be more effective in controlling the course of tics than using the drug acutely to treat an exacerbation." 06/01/1989 - "However, pimozide proved immediately effective in suppressing tics and this improvement was maintained at follow-up" 07/01/2001 - "The symptoms improved considerably in 82% of the patients with eye tics on treatment with a neuroleptic (pimozide)" 03/31/2000 - "Pimozide is an antipsychotic agent also used to treat facial tics" 06/01/1990 - "Pimozide in children with chronic motor tics." Order ALL the reference details at left...
7.	Methylphenidate (Ritalin)FDA LinkGeneric 01/01/2004 - "This study analyzes the incidence of tics reported across five studies of children with ADHD who received methylphenidate (MPH)-based therapy as part of the clinical development program for once-daily OROS MPH (CONCERTA McNeil Consumer & Specialty Pharmaceuticals, Fort Washington, PA)" 02/26/2002 - "Prior recommendations to avoid methylphenidate in these children because of concerns of worsening tics are unsupported by this trial." 04/01/1999 - "BACKGROUND: This study examined changes in attention-deficit hyperactivity (ADHD) behaviors and motor and vocal tics during long-term treatment with methylphenidate" 01/01/2006 - "It is now accepted that tics are a frequently occurring behavioural manifestation of ADHD itself and the evidence for or against their exacerbation by treatment with dl-threo-methylphenidate or other stimulants remains highly contradictory" 12/01/2005 - "Methylphenidate was not associated with tic worsening." Order ALL the reference details at left...
8.	aripiprazole (Abilify)FDA Link 01/01/2006 - "We report recent experiences with treatment with aripiprazole, a novel antipsychotic agent, which not only improved motor and vocal tics but also ameliorated some behavioural symptoms of the GTS cluster" 04/01/2008 - "Additional double-blind studies are needed to establish the definitive efficacy of aripiprazole in treating children and adolescents with chronic tic symptoms." 01/07/2008 - "The patient is now treated with aripiprazole and there is a marked reduction of tics and no side effects." 07/01/2007 - "The initial dose of 5 mg/day aripiprazole for 2 weeks was also found to reduce tic symptoms significantly (Total Tic scores decreased from 26.7 +/- 5.5 to 17.9 +/- 8.7, p < .001)" 07/01/2007 - "After a mean of 9.8 +/- 4.8 mg/day of aripiprazole for 8 weeks, there was a 52.8% reduction in the mean YGTSS Total Tic scores (from 26.7 +/- 5.5 to 12.6 +/- 7.6, p < .001)" Order ALL the reference details at left...
9.	olanzapine (Zyprexa)FDA Link 03/01/2007 - "In 17 case reports of children and adolescents with aggression (42, 45), associated with tics in 10 patients (49), treatment with olanzapine from 2 weeks to 10 months lowered the presenting symptoms, enhanced the cooperation, and improved the mood of the patients" 10/01/2008 - "RESULTS: Over the 6-week trial, olanzapine administration was associated with a significant decrease in total tic severity as measured by the Yale Global Tic Severity Scale (30% reduction by week 6; effect size 0.49)" 01/01/2004 - "Olanzapine produced clinically and statistically significant reductions of aggression and tic severity from baseline to trial completion, as measured by the Achenbach Child Behavior Checklist (CBCL) and Yale Global Tic Severity Scale (YGTSS)" 12/01/2007 - "Olanzapine monotherapy for late-onset vocal tics in a schizophrenic patient." 12/01/2005 - "CONCLUSIONS: This case report further supports the available literature on the use of olanzapine as a therapeutic strategy for tics in GTS and draws attention to its possible use for comorbid behavioural disorders" Order ALL the reference details at left...
10.	Nicotine FDA Link 06/01/2005 - "A single dose of nicotine reduced tic severity as assessed by blind video scoring in the majority of patients" 04/01/2004 - "Secondary efficacy measures, including patient self-reports and parental ratings, found nicotine to reduce complex tics and improve behaviors related to inattention" 01/01/1989 - "This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic treatment alone" 04/01/2004 - "Given the attentional disturbances associated with this syndrome, and the improvements in attentional processes reported with nicotine, this randomized, double-blind, placebo-controlled trial examined the acute (4 h) and sustained (2 weeks) effects of a single dose of transdermal nicotine on clinical (i.e., tics), attentional (continuous performance task, event-related potential, patient and parental reports) and behavioral symptoms in 23 children and adolescents with TS receiving neuroleptic treatment" 03/01/1997 - "Differential effects of transdermal nicotine on microstructured analyses of tics in Tourette's syndrome: an open study." Order ALL the reference details at left...

Therapies and Procedures

1.	Deep Brain Stimulation 03/01/2007 - "Recently, deep brain stimulation, by modulating neuronal activity in structures involved in the pathophysiology of the disease, has become a promising therapeutical approach, producing a marked decrease in the severity of tics over that obtained with other treatments." 04/01/2008 - "Current knowledge of cortico-basal ganglia-thalamocortical circuits provide explanations for the beneficial effects of deep brain stimulation (DBS) on tics" 08/01/2007 - "We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation" 05/01/2006 - "In both cases, deep brain stimulation (DBS) resulted in a substantial reduction of tics and compulsions" 02/14/2006 - "Hemi tics and deep brain stimulation." Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 10/02/1999 - "Symptom severity was rated at baseline, and at 1 month and 12 months after treatment by use of standard assessment scales for OCD, tics, anxiety, depression, and global function" 09/01/1987 - "Follow-up data showed that both tics were still at low levels one, two, four and eight months after treatment" 02/01/2004 - "Vocal tics improved after treatment in 93% patients, with 50% being tic-free" 03/01/2002 - "Using the TSSL, there was a significant improvement of tics (p=0.015) and obsessive-compulsive behavior (OCB) (p = 0.041) after treatment with Delta(9)-THC compared to placebo" 06/01/2005 - "Tics in three children affected with TD showed no improvement after treatment with several neuroleptic drugs (D2 blockers) at appropriate doses" Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 09/01/2008 - "Data were grouped into four categories: Activity Performance (40% of the CI showed that patients were more independent, while 60% revealed that some kind of activity was restricted due to the TIC); Altered Body Image (57% showed the patients' dissatisfaction after the TIC implant, 14% of the CI revealed pre-implant problems, 28% of the CI showed that the TIC favored body esthetics); Catheter Implantation (75% of the CI revealed catheter implantation as a traumatizing procedure, while 25% of the CI revealed patients remained calm and confident during the procedure); Chemotherapy Infusion (100% of the CI showed that the catheter made chemotherapy easier)." 04/01/2008 - "Specific OCD subtypes can be derived utilizing the following strategies: symptom factor analysis, comorbidity latent class analysis, concurrent internalizing disorders, concurrent externalizing disorders, tic-related subtype and early-onset subtype are reviewed in relation to data on differential pharmacotherapy response" 06/01/2007 - "In children and adolescents with ADHD plus CTD both ADHD and tic symptoms can be treated by behavioral interventions alone or in combination with pharmacotherapy" 03/01/2007 - "The decision to start a course of drug therapy depends largely on the impact of the patient's tics on his personal life" 04/01/2006 - "In many patients with TS, symptom management requires pharmacotherapy for tics or coexisting conditions" Order ALL the reference details at left...
4.	Lasers (Laser) 01/12/2006 - "We report here the formation study of TiC nanocrystals through the direct carburization of Ti/O/C nanopowders grown by laser pyrolysis" 01/15/2006 - "Using simulations of laser scanning microscopy image time series, we investigate the effect of spatiotemporal sampling, particle density, noise, sampling frequency, and photobleaching of fluorophores on the recovery of transport coefficients and number densities by TICS" 09/01/2004 - "METHODS: For in vitro experiments, cultured HeLa cells were incubated with TICS at pH 7.1, 6.5 or 6.2 and then scored for dye uptake, viability and sensitivity to laser (740 nm) irradiation" 03/01/2006 - "METHODS: HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability" 01/12/2006 - "TiC nanocrystal formation from carburization of laser-grown Ti/O/C nanopowders for nanostructured ceramics." Order ALL the reference details at left...
5.	Electrodes (Electrode) 01/01/2008 - "She underwent removal of the internal capsule electrodes and placement of centromedian nucleus thalamic stimulators with significantly improved tic control" 09/01/2007 - "A series of photoelectrochemical measurement showed an increase in photovoltage and in photocurrent for the electrode of anodized TiC sample" 09/01/1998 - "In thoracic impedance cardiography (TIC) measurements the neck electrodes are often positioned at the basis of the neck, close to the neck-thorax transition" 04/01/1996 - "Two 18-gauge radiofrequency TIC needle electrodes (Radionics, Burlington, MA) are used" 01/01/1991 - "Sensory trigeminal evoked potentials (STEPs) induced by separate successive orthodromic cutaneous stimulation of the three trigeminal divisions and recorded by the isolated tip of a transoval thermocouple electrode, together with motor trigeminal evoked potentials (MTEPs) elicited by stimulation of the trigeminal ganglion and recorded in the ipsilateral temporal muscle, were sequentially examined in six patients undergoing percutaneous tic treatment during gradual rostro-caudal electrode withdrawal" Order ALL the reference details at left...

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