Whooping Cough (Pertussis)

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4333 relevant articles (288 outcomes, 510 trials/studies) found for this Disease

Description: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.

Also Known As:

Pertussis; Cough, Whooping; Pertusses

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Infection: 225242

Respiratory Tract Infections: 5595

Whooping Cough: 4333

Bacterial Infections: 6830

Gram-Negative Bacterial Infections: 240

Bordetella Infections: 12

Whooping Cough: 4333

Respiratory Tract Diseases: 377

Respiratory Tract Infections: 5595

Whooping Cough: 4333

Related Diseases

1.	Diphtheria
2.	Tetanus
3.	Infection
4.	Whooping Cough (Pertussis)
5.	Measles

Experts

1.	Schuerman, Lode: 10 articles (08/2008 - 07/2004)
2.	Halperin, Scott A: 9 articles (04/2007 - 05/2002)
3.	Gzyl, Anna: 8 articles (01/2007 - 01/2004)
4.	Slusarczyk, Janusz: 7 articles (01/2007 - 01/2004)
5.	Augustynowicz, Ewa: 7 articles (01/2007 - 01/2004)
6.	Pichichero, Michael E: 6 articles (10/2007 - 09/2002)
7.	Corbel, M J: 6 articles (04/2007 - 01/2000)
8.	Rabczenko, Daniel: 6 articles (01/2007 - 01/2004)
9.	Mastrantonio, P: 6 articles (07/2003 - 06/2000)
10.	Jacquet, Jeanne-Marie: 5 articles (05/2008 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Whooping Cough:

1.	VaccinesIBA 01/01/1997 - "Vaccine efficacy of the most efficacious acellular pertussis vaccines in the three recent placebo-controlled clinical trials, when estimated using the primary clinical case criterion, does not change substantially with the inclusion of serological confirmation in addition to culture confirmation. " 04/01/2007 - "Since the efficacy of the currently available acellular pertussis vaccines is, at the best, the same as that of the whole-cell vaccines, any improvement of the current status cannot be expected. " 07/01/2006 - "This observation can best be explained by an increased awareness of the disease, the availability of new diagnostic tests and, perhaps, suboptimal efficacy of some pertussis vaccines. " 05/01/2001 - "Since 1940, vaccination with whole cell vaccines, composed of Bordetella pertussis extracts, has dramatically reduced the incidence of whooping cough. " 02/01/2000 - " (3) The efficacy of the best acellular pertussis vaccines does not exceed 85% after primary vaccination. " Order ALL the reference details at left...
2.	Pertussis VaccineIBA 12/01/2006 - "CONCLUSION: Administering all 5 doses of pertussis vaccine and the fifth dose at age 5 years with at least 36 months between the fourth and fifth doses provided the best protection against pertussis among children and adolescents in this outbreak." 07/15/2002 - "Thus, even after partial vaccination, acellular pertussis vaccine is highly effective in preventing hospitalizations for pertussis." 03/01/1991 - "These findings suggest that, since its introduction, the whole-cell pertussis vaccine produced in South Africa has been highly effective in controlling whooping cough. " 05/01/1985 - "The incidence of pertussis has been dramatically reduced in many areas of the world over the past 25 years by the use of pertussis vaccine. " 01/01/1997 - "Household studies in the two recently concluded Swedish pertussis vaccine efficacy trials demonstrated that one monocomponent and one five-component candidate acellular pertussis vaccine had reasonably good protective efficacy against clinically typical pertussis after household exposure. " Order ALL the reference details at left...
3.	AntigensIBA 11/01/2009 - "pertussis-derived antigens, confer efficient protection against B. " 03/01/1989 - "pertussis was dependent on the dose of rat testicular homogenate in the inoculum and found to be effective only at lower doses of antigen (10 mg/rat). " 12/01/1975 - "A greater epidemiological efficacy of pertussis antigen was revealed by prolonged observation in immunization by the AKdeltaC-AKdeltaC-KB sheme in comparison with immunization by the official scheme (pertussis incidence per 100 thousand children proved to be 12.7 and 71.2, respectively)." 04/01/2009 - "The lack of a clear correlation between the levels of antibody to pertussis antigens and protection against disease lends credence to the possibility that cell-mediated immunity provides primary protection against disease. " 01/01/2009 - "pertussis antigens, provide little if any protection against B. " Order ALL the reference details at left...
4.	AntibodiesIBA 04/01/1999 - "CONCLUSIONS: These preliminary data suggest that CMI may have an important role in protection against clinical pertussis but do not exclude a role for antibodies. " 12/01/2005 - "pertussis induced rapid neutrophil recruitment and was rapidly cleared from the lungs by adoptively transferred antibodies. " 12/01/2001 - "A statistically significant correlation was found between the level of PTox-induced antibodies and protection against pertussis. " 09/01/2007 - "Additional support for the efficacy of maternal vaccination comes from studies showing that transfer of antibodies confers protection against pertussis. " 05/01/2005 - "Indirect evidence suggests that maternal antibodies provide short lived protection against fatal pertussis. " Order ALL the reference details at left...
5.	ToxoidsIBA 01/01/1963 - "[EFFECT OF TOXOIDS ON THE IMMUNOGENIC VALUE OF THE PERTUSSIS COMPONENT.]" 01/01/1997 - "Examination of similarities between diphtheria and pertussis and their toxoids provide insight into vaccine-induced protection to Bordetella pertussis." 10/19/1995 - "There were 312 cases of pertussis (72 in the DTP-toxoids group and 240 in the DT-toxoids group) that met the clinical criterion (paroxysmal cough lasting > or = 21 days) and laboratory criteria for pertussis as defined by the World Health Organization. " 01/01/1988 - "These data indicate that routine booster immunization of the adult population, probably every 10 years with tetanus-diphtheria toxoids (Td), is feasible and might be beneficial in control of pertussis. " 12/15/2006 - "To reduce pertussis morbidity among adults and maintain the standard of care for tetanus and diphtheria prevention and to reduce the transmission of pertussis to infants and in health-care settings, the Advisory Committee on Immunization Practices (ACIP) recommends that: 1) adults aged 19-64 years should receive a single dose of Tdap to replace tetanus and diphtheria toxoids vaccine (Td) for booster immunization against tetanus, diphtheria, and pertussis if they received their last dose of Td >or=10 years earlier and they have not previously received Tdap; 2) intervals shorter than 10 years since the last Td may be used for booster protection against pertussis; 3) adults who have or who anticipate having close contact with an infant aged <12 months (e.g., parents, grandparents aged <65 years, child-care providers, and health-care personnel) should receive a single dose of Tdap to reduce the risk for transmitting pertussis. " Order ALL the reference details at left...
6.	pertussis toxoidIBA 02/01/1997 - "CONCLUSIONS: A monocomponent pertussis toxoid vaccine induces significant protection against pertussis for at least 2 years after the third injection. " 09/09/2004 - "We found that routine vaccination with pertussis toxoid vaccine was effective against both hospitalisation with pertussis (VE, 93% for three doses) and non-hospitalised pertussis (VE, 78% for three doses). " 10/19/1995 - "A pharmacologically inert, acellular pertussis-toxoid vaccine that is easily standardized is safe and confers substantial protection against pertussis." 06/01/1999 - "Protection against pertussis with a monocomponent pertussis toxoid vaccine." 04/01/1997 - "In conclusion, the pertussis toxoid vaccine provides protection against pertussis both after household and community exposure." Order ALL the reference details at left...
7.	Diphtheria-Tetanus-Pertussis Vaccine (DPT Vaccine)IBA 01/01/2009 - "A Japanese DPT vaccine dose of 0.2 mL thus proved effective against pertussis in adults." 05/01/1990 - "The point estimate of protective efficacy of the acellular DTP vaccine against typical pertussis was (6/10 - 1/9)/(6/10) x 100 = 81%. " 10/01/1998 - "We analyzed vaccine efficacy of an acellular pertussis component DTP vaccine (DTaP) and a whole cell pertussis component DTP vaccine (DTP) by compliance category. " 01/01/1992 - "[Improvement in the laboratory methods of assessing the safety of the of the pertussis component of DPT vaccine adsorbed]" 06/01/2009 - "A prospective vaccination study using the local DTwP vaccine in parallel to a WHO approved standard vaccine, could enable assessment of immunogenicity of the pertussis component." Order ALL the reference details at left...
8.	Pertussis ToxinIBA 08/01/2004 - "pertussis was based on the amplification of a section of the IS481 insertion sequence and confirmation of positive results was based on a sequence of the pertussis toxin promoter region. " 10/01/1987 - "pertussis strains were utilized to study the biogenesis of pertussis toxin. " 08/01/2009 - "We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (Ptx) production. " 07/01/2008 - "parapertussis are the etiological agents of pertussis, yet the former has a higher incidence and is the cause of a more severe disease, in part due to pertussis toxin. " 05/01/2008 - "Using data on 195 participants (>or=7 years old) from an epidemiological study, we assessed the sensitivity, specificity, and performance (Youden index) for pertussis diagnosis of the pertussis toxin enzyme-linked immunosorbent assay (using single and paired serology) and of real-time PCR assays (using the IS481 and ptxA-Pr targets). " Order ALL the reference details at left...
9.	Diphtheria-Tetanus-acellular Pertussis Vaccines (Tripedia)IBA 08/01/2005 - "CONCLUSIONS: Any combination of > or =3 DTP/DTaP vaccine doses for children 6 to 59 months of age was highly protective against pertussis. " 05/01/2009 - "Pertussis and the DTaP Vaccine." 08/01/2008 - "In fully immunised children, receipt of all three doses of the primary course as an acellular pertussis-containing combination vaccine (DTaP-Hib) increased the risk of vaccine failure (OR 2.88 (95% CI 0.99 to 8.37), p = 0.01). " 08/01/2005 - "The proportions of children who received 0, 1 or 2, 3, and > or =4 pertussis (DTP and/or DTaP) vaccine doses among case subjects were 26%, 14%, 26%, and 34% and among control subjects were 2%, 8%, 33%, and 57%, respectively. " 01/01/2005 - "The economic impact of pertussis and transmission from adults to vulnerable infants provides a cost-benefit justification for widespread use of DTaP vaccines in all age groups with routine boosting every 10 years." Order ALL the reference details at left...
10.	pertactinIBA 11/01/1995 - "Our subgroup data suggest that high values of antibody to pertactin and high agglutinin titers may be predictive of protection against clinical pertussis." 12/15/2001 - "We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. " 12/15/2001 - "However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. " 08/12/2008 - "pertussis strains Tohama I and 18-323 as the commercial Infanrixtrade mark vaccine that also includes PT and FHA but pertactin (PRN) instead of rBrkA. " 12/01/2007 - "pertussis pertactin gene sequence for the region that encompasses the RT-PCR probe and primers is nearly identical to that of many Bordetella bronchiseptica strains of human and avian origin. " Order ALL the reference details at left...

Therapies and Procedures

1.	Intranasal Administration 05/01/1998 - "pertussis strains are promising vectors for the simultaneous protection against pertussis and heterologous diseases by a single intranasal administration." 07/01/2005 - "Bordetella pertussis, the etiologic agent of whooping cough, is a highly infectious human pathogen capable of inducing mucosal and systemic immune responses upon a single intranasal administration. " 04/12/2006 - "pertussis, induced by a single intranasal administration of BPZE was at least as high as that induced by two injections of commercial acellular vaccine. " 08/01/2002 - "pertussis strain producing Fha44 instead of FHA does not induce anti-FHA antibodies, whereas such antibodies can readily be induced by intranasal administration of purified Fha44. " 12/12/2001 - "pertussis strains were able to prime mice for the production of anti-TTFC serum antibodies upon intranasal administration, suggesting the feasibility of using recombinant attenuated B. " Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 08/01/2001 - "Current pharmacotherapy of pertussis." 02/15/1982 - "[Modern concepts of drug therapy of whooping cough]" 08/01/1961 - "[Chemotherapy of experimental whooping cough infection with 4,4'-diisobutyryldiaminodiphenyl sulfone.]" 07/01/1984 - "Twenty-seven children with various childhood malignancies who were in clinical remission and receiving maintenance chemotherapy were given diphtheria-pertussis-tetanus (DPT) immunizations. " 02/01/2009 - "In this randomized controlled study, we studied the effect of immune responses to diphtheria-tetanus-pertussis (DTP) booster vaccination in children 6 months after completing chemotherapy. " Order ALL the reference details at left...
3.	Chemoprevention 10/01/1999 - "Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxis in preventing secondary cases of pertussis. " 01/12/2008 - "Doctors should always ascertain the presence of a newborn infant in the household of pertussis patients and consider chemoprophylaxis immediately, even ahead of notification. " 03/01/2006 - "Pertussis chemoprophylaxis is indicated for contacts at risk of death or of severe complications if infected with Bordetella pertussis; e.g. " 03/01/2006 - "[Pertussis chemoprophylaxis: a sterile effort?]" 08/29/2005 - "The article presents clinical features of pertussis in older children and adults as well as in unvaccinated infants, with the aim to increase the awareness of the disease and to promote implementation of chemoprophylaxis in households with infants. " Order ALL the reference details at left...
4.	Microspheres (Microsphere) 02/01/2006 - "pertussis antigens can be measured easily and accurately using a tetraplex microsphere system." 04/01/1995 - "pertussis antigens elicits high levels of specific antibody coinciding with protection against infection when these microspheres are administered to the respiratory tract. " 09/01/1997 - "pertussis infection did not significantly alter monocyte phagocytosis of complement-opsonized latex particles, indicating that B. " 03/15/2001 - "Neuronal C5a receptors bound C5a-coated fluorescent microspheres, and primary rodent hippocampal neurons responded to C5a with increased calcium fluxes via a pertussis-sensitive, presumably Gi-coupled protein. " Order ALL the reference details at left...
5.	Antibiotic Prophylaxis 08/01/1997 - "RESULTS: A whole immunization conferred good protection against pertussis with an estimated VE higher than 92% in three surveys, lower in the fourth survey (84%) in which antibiotic prophylaxis was set up very rapidly. " 09/15/1997 - "Effective management of pertussis outbreaks requires early diagnosis and treatment of cases, antibiotic prophylaxis of contacts and accelerated vaccination of susceptible infants and children. " 08/01/2005 - "In the day care centres an antibiotic prophylaxis should be given to children who have received less than four vaccine shots against pertussis and to the personnel contact to the cases as well. " Order ALL the reference details at left...

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