Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection.
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| Abstract |
Helicobacter pylori infection causes chronic inflammation, which can lead to gastric carcinoma. A double immunofluorescence labeling study demonstrated that the level of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) apparent in gastric gland epithelium was significantly higher in gastritis patients with H. pylori infection than in those without infection. A significant accumulation of proliferating cell nuclear antigen, a prognostic factor for gastric cancer, was observed in gastric gland epithelial cells in patients with H. pylori infection as compared to those without infection, and its accumulation was closely correlated with the formation of 8-nitroguanine and 8-oxodG. These results suggest that nitrosative and oxidative DNA damage in gastric epithelial cells and their proliferation by H. pylori infection may lead to gastric carcinoma. 8-Nitroguanine could be not only a promising biomarker for inflammation but also a useful indicator of the risk of gastric cancer development in response to chronic H. pylori infection.
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| Authors | Ning Ma, Yukihiko Adachi, Yusuke Hiraku, Noriyuki Horiki, Shinichirou Horiike, Ichiro Imoto, Somchai Pinlaor, Mariko Murata, Reiji Semba, Shosuke Kawanishi |
| Journal | Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 319 Issue 2 Pg. 506-10 (Jun 25 2004) ISSN: 0006-291X [Print] United States |
| PMID | 15178435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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