Abstract | BACKGROUND: METHODS: This study, which was conducted by the North Central Cancer Treatment Group, evaluated 42 patients who were asymptomatic and had manifested, progressive prostate specific antigen (PSA) elevation with hormone therapy. Continued use of luteinizing hormone-releasing hormone agonist was permitted; however, patients were ineligible if they had received other treatments for their disease in the preceding 4 weeks or if they had received a long-acting antiandrogen therapy in the preceding 6 weeks. Patients were instructed to take 6 grams of green tea per day orally in 6 divided doses. Each dose contained 100 calories and 46 mg of caffeine. Patients were monitored monthly for response and toxicity. RESULTS:
Tumor response, defined as a decline >/= 50% in the baseline PSA value, occurred in a single patient, or 2% of the cohort (95% confidence interval, 1-14%). This one response was not sustained beyond 2 months. At the end of the first month, the median change in the PSA value from baseline for the cohort increased by 43%. Green tea toxicity, usually Grade 1 or 2, occurred in 69% of patients and included nausea, emesis, insomnia, fatigue, diarrhea, abdominal pain, and confusion. However, six episodes of Grade 3 toxicity and one episode of Grade 4 toxicity also occurred, with the latter manifesting as severe confusion. CONCLUSIONS:
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Authors | Aminah Jatoi, Neil Ellison, Patrick A Burch, Jeff A Sloan, Shaker R Dakhil, Paul Novotny, Winston Tan, Tom R Fitch, Kendrith M Rowland, Charles Y F Young, Patrick J Flynn |
Journal | Cancer
(Cancer)
Vol. 97
Issue 6
Pg. 1442-6
(Mar 15 2003)
ISSN: 0008-543X [Print] United States |
PMID | 12627508
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11200 |
Chemical References |
- Androgens
- Plant Preparations
- Tea
- Prostate-Specific Antigen
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Topics |
- Aged
- Androgens
(pharmacology)
- Camellia sinensis
(chemistry)
- Carcinoma
(drug therapy)
- Complementary Therapies
- Humans
- Male
- Middle Aged
- Phytotherapy
- Plant Preparations
(adverse effects, pharmacology)
- Prostate-Specific Antigen
(analysis)
- Prostatic Neoplasms
(drug therapy)
- Tea
- Treatment Outcome
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