Abstract | BACKGROUND: METHODS: RESULTS: Only 1 of 16 BCC cases was positive for iNOS and the intensity of staining was weak. In most of the 10 cases of Bowen's disease, iNOS was weakly expressed and there was a wide range in the percentage of positive tumor cells. Twelve of the 16 cases of SCC were positive for iNOS and the extent of positivity was greater than in Bowen's disease. Two of the 7 cases of EPD were positive for iNOS, and 12 of the 15 cases of metastatic cancer were positive. Well-differentiated adenocarcinomas were diffusely positive, whereas poorly-differentiated ones showed strong and heterogeneous staining. CONCLUSIONS: These results indicated that the expression of iNOS may reflect the proliferation of tumor cells and that a heterogeneous distribution of iNOS may correlate with a wide variety of biological behavior of tumor cells.
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Authors | M Kagoura, C Matsui, M Toyoda, M Morohashi |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 28
Issue 9
Pg. 476-81
(Oct 2001)
ISSN: 0303-6987 [Print] United States |
PMID | 11553314
(Publication Type: Journal Article)
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Chemical References |
- NOS2 protein, human
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
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Topics |
- Adenocarcinoma
(enzymology, secondary)
- Bowen's Disease
(enzymology, pathology)
- Carcinoma, Basal Cell
(enzymology, pathology)
- Carcinoma, Squamous Cell
(enzymology, pathology)
- Cell Division
- Humans
- Immunohistochemistry
- Nitric Oxide Synthase
(analysis)
- Nitric Oxide Synthase Type II
- Paget Disease, Extramammary
(enzymology, pathology)
- Skin Neoplasms
(enzymology, pathology)
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