Skin Neoplasms (Skin Cancer)

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2688 relevant articles (133 outcomes, 337 trials/studies) found for this Disease

Description: Tumors or cancer of the SKIN.

Also Known As:

Skin Cancer; Neoplasms, Skin; Skin Cancers; Cancer of the Skin; Cancer, Skin; Cancers, Skin; Neoplasm, Skin; Skin Neoplasm; Cancer of Skin

Relationship Network

Disease Context: Research Results

Sweat Gland Neoplasms: 8

Sebaceous Gland Neoplasms: 2

Skin and Connective Tissue Diseases

Skin Diseases: 5932

Skin Neoplasms: 2688

Sweat Gland Neoplasms: 8

Sebaceous Gland Neoplasms: 2

Related Diseases

1.	Melanoma (Melanoma, Malignant)
2.	Neoplasms (Cancer)
3.	Skin Diseases
4.	Keratosis
5.	Basal Cell Carcinoma (Rodent Ulcer)
221 Diseases and 1175 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Euvrard, Sylvie: 9 articles (10/2008 - 03/2003)
2.	Otley, Clark C: 7 articles (06/2006 - 07/2002)
3.	Alberts, David S: 6 articles (05/2008 - 01/2002)
4.	Murphy, G M: 6 articles (02/2008 - 07/2001)
5.	Otley, C C: 6 articles (12/2007 - 05/2000)
6.	Einspahr, Janine G: 5 articles (05/2008 - 01/2002)
7.	Hunter, David J: 5 articles (08/2007 - 05/2004)
8.	Piaserico, S: 5 articles (07/2007 - 03/2000)
9.	Claudy, Alain: 5 articles (07/2007 - 04/2003)
10.	Harden, Paul N: 5 articles (11/2006 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Skin Neoplasms:

1.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2006 - "CONCLUSION: The study suggests that 5-ALA PDT is effective in the treatment of superficial skin cancer and premalignant lesions." 03/01/2004 - "OBJECTIVE: The current study compared the ability of topical and systemic ALA-PDT as well as topical ALA-PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model" 12/01/1994 - "Preliminary trials suggest a role for PDT in the treatment of primary, recurrent, and metastatic nonmelanoma skin cancers" 02/01/2007 - "The use of PDT with systemic photosensitizer needs to be further explored as a modality of treatment for nonmelanoma skin cancer (NMSC)" 01/01/2007 - "Finally, ALA-PDT may be a useful way to prevent new skin cancers in certain high-risk patients." Get all the results and reference details, order at left...
2.	Sunscreening Agents (Sunscreens)IBA 07/01/1981 - "Prevention of long-term UVR effects on skin is a desirable goal; development of personal UVR dosimeters will aid in defining the quantitative nature of the problem; improved sunscreens should provide the means to achieve significant reduction in the incidence of UVR-induced human skin cancer." 01/01/2003 - "Sunscreens are widely advocated to protect against skin cancer but if they offer insufficient protection against immunosuppression they may inadvertently increase skin cancer risk" 11/01/2005 - "This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market." 12/01/2007 - "Targeting mutant p53 shows promise for sunscreens and skin cancer." 09/01/2005 - "In particular, the protection against UV-induced immunosuppression by sunscreens is supposed to reduce the development of UV-induced skin cancer" Get all the results and reference details, order at left...
3.	RetinoidsIBA 12/01/2002 - "RESULTS: Review of the literature demonstrates that the administration of synthetic retinoids has not proved beneficial for otherwise healthy patients with nonmelanoma skin cancer" 12/01/2005 - "A majority of the studies found a decrease in the number of malignant and pre-malignant cutaneous lesions in patients treated with systemic retinoids, with several studies noting increased benefit in those patients with multiple previous skin cancers" 03/01/2002 - "This review focuses on the retinoids and details their results in clinical trials for treatment and prevention of skin cancer" 03/19/1997 - "The effect of retinoids had no significant benefit on squamous or basal cell skin cancers in the high risk subjects on the SKICAP-S/B trial, although intervention duration was less than planned" 01/01/1991 - "Evidence from clinical studies suggests that although topical retinoids have some effect in treating established skin cancers, alternative treatments are more effective" Get all the results and reference details, order at left...
4.	SeleniumIBA 06/01/1985 - "Statistical analyses revealed significant dose-dependent selenium-mediated protection against UV-light-induced skin cancer" 12/01/1990 - "An application is described to a large ongoing randomized controlled clinical trial for the efficacy of nutritional supplements of selenium for the prevention of two types of skin cancer." 02/18/2004 - "Re: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial." 10/01/2003 - "Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial." 12/01/2002 - "Selenium supplementation has reduced the incidence of several internal malignancies but not of nonmelanoma skin cancer" Get all the results and reference details, order at left...
5.	imiquimod (Aldara)FDA Link 07/01/2008 - "Complete remission was observed after 6 to 10 weeks of imiquimod 5% (10 mg/cm of skin cancer) treatment" 05/01/2004 - "Imiquimod has been shown to stimulate the cutaneous immune response and be effective for the treatment of nonmelanoma skin cancers" 01/01/2006 - "Imiquimod, a topical immunomodulator, approved its efficiency in several skin neoplasms and has been shown as a safe treatment for EMPD" 08/01/2007 - "Imiquimod: an immune response modifier in the treatment of precancerous skin lesions and skin cancer." 04/01/2006 - "These data suggest that topical imiquimod applications may play a role in preventing UV-induced impairment of the skin immune system, which is thought to be one of the critical events that allow the development of UV-induced skin cancers." Get all the results and reference details, order at left...
6.	Melanins (Melanin)IBA 04/01/1989 - "There appeared to be an overrepresentation of types I and II. Increased melanin pigmentation may therefore be either directly or indirectly protective against the development of skin cancers in patients who have received low-dose superficial ionizing radiation for benign disease" 04/01/1991 - "Melanin protection against sun-induced skin cancers gives a false sense of well-being" 10/01/2002 - "Ultimately, the genetic and chemical assessment of melanin synthesis rather than skin colour will be the best indicator for skin cancer risk, and such genetic association studies combined with functional analysis of variant alleles should provide the link to understanding skin phototypes." 09/01/2008 - "Nevoscope based multi-spectral trans-illumination imaging is aimed at characterization of skin-lesions for early diagnosis of skin-cancers by reconstructing distributions of melanin and blood" 05/01/2008 - "This article outlines the major acute and chronic effects of UVR on human skin, the properties of melanin, the regulation of pigmentation and its effect on skin cancer prevention." Get all the results and reference details, order at left...
7.	silybin (silibinin)IBA 09/01/2005 - "Overall, the protective efficacy of silibinin against skin cancer is supported by sound mechanistic rationale in animal and cell culture studies, and suggests its potential use for humans." 09/01/2005 - "Mechanisms and preclinical efficacy of silibinin in preventing skin cancer." 05/27/2005 - "Together, these findings suggest that silibinin preferentially activates the DNA-PK-p53 pathway for apoptosis in response to UVB-induced DNA damage, and that this could be a predominant mechanism of silibinin efficacy against UVB-induced skin cancer." 03/01/2002 - "In an attempt to translate these findings to human skin cancer and to establish biological significance of physiologically achievable level, effect of plasma concentration of silibinin was next examined in human epidermoid carcinoma A431 cells" 05/01/2005 - "Based on our recent study reporting strong efficacy of silibinin against photocarcinogenesis, we assessed here the protective effects of its dietary feeding on UVB-induced biomarkers involved in NMSC providing a mechanistic rationale for an early-on silibinin efficacy in skin cancer prevention" Get all the results and reference details, order at left...
8.	Isotretinoin (Accutane)FDA LinkGeneric 07/01/1981 - "Preliminary studies with oral 13-cis-retinoic acid have not demonstrated any effects to date on UV-induced skin cancer formation." 01/01/2005 - "A combination of systemic isotretinoin and interferon-alpha-2a may provide a more potent effect than isotretinoin alone in the prevention and treatment of skin cancers" 09/01/2004 - "High-dose isotretinoin has mainly been utilized in those patients at high-risk for multiple new skin cancers where the risk of morbidity from side effects is overshadowed by the benefit to the patient." 01/01/1993 - "Isotretinoin does prevent skin cancer." 03/04/1992 - "BACKGROUND: High-dose isotretinoin has been reported to have a prophylactic effect on nonmelanoma skin cancer, although it is associated with significant toxicity" Get all the results and reference details, order at left...
9.	SilymarinIBA 04/16/1997 - "PURPOSE: We evaluated the protective effects of silymarin, a flavonoid compound isolated from the milk thistle plant, against UVB radiation-induced nonmelanoma skin cancer in mice and delineated the mechanism(s) of its action" 01/01/2005 - "Wide range of in vivo mechanistic studies indicated that silymarin possesses antioxidant, anti-inflammatory and immunomodulatory properties which may lead to the prevention of skin cancer in in vivo animal models" 08/01/2002 - "In both animal and cell culture studies, we have shown that silymarin, a naturally occurring polyphenolic flavonoid antioxidant, exhibits preventive and anticancer effects against skin cancer" 06/01/2007 - "In skin cancer, silymarin treatment inhibits ultraviolet B radiation or chemically initiated or promoted carcinogenesis" 07/01/2006 - "As UVB-induced immunosuppression has been implicated in the development of skin cancer, we investigated whether silymarin can modulate the effects of UVB radiation on the immune system" Get all the results and reference details, order at left...
10.	InterferonsIBA 09/01/1993 - "These data indicate that XP lymphocytes have a defect in production of interferons and suggest that defective interferon production, as well as DNA repair defects, may play an important role in the susceptibility of XP patients to skin cancer." 09/01/1993 - "We examined natural killer (NK) cell activity and interferon production in peripheral blood lymphocytes (PBL) of eight XP patients who had multiple primary skin cancers" 09/01/1993 - "Impaired interferon production and natural killer cell activation in patients with the skin cancer-prone disorder, xeroderma pigmentosum." 01/31/1981 - "Interferon treatment of skin cancer in patients with epidermodysplasia verruciformis." 01/01/1995 - "Preferentially, the interferons and interleukin-2 were found to be effective in treating skin cancers" Get all the results and reference details, order at left...
720 Drugs and Important Bio-Agents and 1995 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 04/01/1993 - "Photodynamic therapy is a modality that potentially could be most helpful in treating multicentric skin cancers" 12/01/2000 - "These observations may be important for improving the efficacy of photodynamic therapy for the treatment of skin cancer and possibly other skin disorders" 03/01/2003 - "It remains to be seen whether this enhanced local bioavailability of the protoporphyrin prodrug can allow improved photodynamic therapy for the treatment of skin cancer." 07/09/2008 - "The potential of these photosensitive nitrosyl-dye conjugates as (i) biological tools to study the effects of NO in cellular environments and (ii) "trackable" NO donors in photodynamic therapy of malignancies (such as skin cancer) has been discussed." 12/01/2000 - "Photodynamic therapy of skin cancers: sensitizers, clinical studies and future directives." Get all the results and reference details, order at left...
2.	Chemoprevention 10/01/2003 - "CONCLUSION: The total histologic score, having demonstrated reliability on repeated readings and validity in its association with biopsy location and histologic score, is a reliable and valid end point for judging the efficacy of agents in skin cancer chemoprevention studies" 05/01/2001 - "The efficacy of systemic retinoid skin cancer chemoprevention was first demonstrated in these disorders" 02/01/2008 - "While the roles of Nrf2 and phase 2 genes in chemoprevention of carcinogenesis have been well described; only few studies have dealt with their role in skin cancer" 08/01/2007 - "This result has pointed the way toward the detailed study of Raf/Mek/Erk pathway signaling in skin cancer development and its potential as a target pathway for chemoprevention by ATRA and other chemopreventive drugs." 01/28/2004 - "Studies have indicated that topical application of POH may prove to be effective as a skin cancer chemoprevention therapy" Get all the results and reference details, order at left...
3.	Transplants (Transplant) 06/01/2006 - "OBJECTIVE: To determine whether an intensive educational program focused on the risk of skin cancer in organ transplant recipients, a population at high risk for development of skin cancer because of immunosuppression, produced measurable improvement in patient knowledge and sun-protective behavior" 06/01/2006 - "Systemic retinoid therapy is thought to be beneficial for chemosuppression of skin cancers in solid organ transplant recipients" 12/01/2007 - "BACKGROUND: Although evidence supports the efficacy of reducing immunosuppression for transplant-associated skin cancer, clinical thresholds for and risks associated with reduction are not well defined" 07/01/2007 - "This study examines the association of keratotic skin lesions with the development of skin cancer in 915 solid organ-transplant recipients in five European countries" 05/01/2006 - "Our study suggests that although LTRs are at higher risk of developing nonmelanoma skin cancer than the general population, the risk is comparable with other solid organ transplant recipients." Get all the results and reference details, order at left...
4.	Mohs Surgery (Mohs' Micrographic Surgery) 01/01/1991 - "Mohs Micrographic Surgery is a technique offering superior treatment for skin cancer with cure rates of 99% for primary and 94.4% for recurrent BCC, greater than 94% for SCC" 04/01/2006 - "CONCLUSION: Mohs micrographic surgery is unsurpassed in its efficacy in treating a wide variety of nonmelanoma skin cancers" 06/01/2004 - "Patient self-reported history (as determined by responses to a survey) was compared with the gold standard of chart documentation of a pathology report or a procedure note from Mohs micrographic surgery demonstrating skin cancer" 02/01/2003 - "STUDY DESIGN: Cross-sectional study of 121 consecutive patients (65 female and 56 male patients) presenting to a dermatological Mohs surgery clinic with nonmelanoma skin cancer of the head and neck" 09/01/1998 - "OBJECTIVE: To study nasal valve insufficiency in 100 consecutive patients who had Mohs surgery for skin cancer of the nose, review the literature, and report methods for prevention of this complication" Get all the results and reference details, order at left...
5.	Transplantation (Transplant Recipients) 02/01/2005 - "OBJECTIVE: To review the rationale for and evidence supporting the efficacy of reduction of immunosuppression for severe skin cancer in transplant recipients" 09/18/2007 - "Studies of immune-suppressed transplant recipients and patients with biopsy-proven skin cancer have confirmed that ultraviolet (UV) radiation-induced immune suppression is a risk factor for the development of skin cancer in humans" 07/01/2007 - "The purpose of this study was to evaluate the knowledge, attitude, and practices of KTRs regarding skin cancer after transplantation and to identify the role of education in motivating these patients to practice sun-protective behaviours" 01/01/2007 - "DISCUSSION: Dermatologic follow-up of transplant recipients has rarely been investigated and our study shows that monitoring of skin cancer is probably inadequate" 05/01/2006 - "This study demonstrates that specialist advice can improve self-reported knowledge of skin cancer risk and sun protective behaviour in cardiac transplant recipients" Get all the results and reference details, order at left...
93 Therapies and Procedures and 1016 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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