Squamous Cell Carcinoma (Epidermoid Carcinoma)

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17855 relevant articles (533 outcomes, 2845 trials/studies) found for this Disease

Description: A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Also Known As:

Epidermoid Carcinoma; Carcinoma, Squamous; Carcinoma, Squamous Cell; Carcinomas, Epidermoid; Carcinomas, Planocellular; Carcinomas, Squamous; Carcinomas, Squamous Cell; Epidermoid Carcinomas; Planocellular Carcinoma; Planocellular Carcinomas; Squamous Carcinoma; Squamous Carcinomas; Squamous Cell Carcinomas; Carcinoma, Epidermoid; Carcinoma, Planocellular

Relationship Network

Disease Context: Research Results

Neoplasms: 387500

Neoplasms by Histologic Type: 1

Glandular and Epithelial Neoplasms: 238

Carcinoma: 89409

Squamous Cell Carcinoma: 17855

Bowen's Disease: 438

Squamous Cell Neoplasms: 735

Squamous Cell Carcinoma: 17855

Bowen's Disease: 438

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenocarcinoma
3.	Carcinoma (Carcinomatosis)
4.	Neoplasm Metastasis (Metastasis)
5.	Basal Cell Carcinoma (Rodent Ulcer)

Experts

1.	Tsukuda, Mamoru: 19 articles (08/2008 - 04/2002)
2.	Ochiai, Takenori: 17 articles (08/2008 - 02/2002)
3.	Sturgis, Erich M: 16 articles (10/2008 - 09/2002)
4.	Shimada, Yutaka: 16 articles (02/2007 - 01/2002)
5.	Wei, Qingyi: 15 articles (10/2008 - 09/2002)
6.	Shimada, Hideaki: 15 articles (08/2008 - 02/2002)
7.	Wu, Min: 15 articles (03/2008 - 01/2002)
8.	Kuwano, Hiroyuki: 15 articles (02/2007 - 04/2002)
9.	Kato, Hiroyuki: 15 articles (02/2007 - 04/2002)
10.	Van Waes, Carter: 14 articles (08/2008 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Squamous Cell Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 02/01/2004 - "cis-Diaminodichloroplatinum (II) (cisplatin) is one of the most effective anticancer drugs and is widely used for the treatment of squamous cell carcinoma (SCC)" 11/01/1988 - "Chemotherapeutic regimens containing Cisplatin are the most effective in the treatment of squamous cell carcinoma of the head and neck" 09/01/2000 - "BACKGROUND: This phase II study evaluates the tolerability and efficacy of concurrent hyperfractionated radiation therapy (HFX-RT) and high-dose intra-arterial (IA) cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)" 07/01/2001 - "The combination of high-dose intra-arterial cisplatin and radiation therapy is effective in improving survival and organ preservation rates in patients with previously untreated, advanced squamous cell carcinoma of the head and neck" 12/15/1986 - "Cisplatin was used successfully to treat 2 dogs with metastatic squamous cell carcinoma" Order ALL the reference details at left...
2.	Fluorouracil (Carac)FDA LinkGeneric 11/01/2001 - "A prospective study was done to test the efficacy of 5-fluorouracil (topical and systemic) in multiple and unresectable histologically proven facial squamous cell carcinomas (SCC) secondary to XP" 05/01/2005 - "Recurrent squamous cell carcinoma in the neopharynx treated successfully with topical 5-fluorouracil." 03/01/2000 - "CONCLUSIONS: Topical 1% 5-FU is effective in the treatment of recurrent, incompletely excised, and selected untreated conjunctival squamous cell carcinomas" 10/01/1999 - "Because multiple infusion of CDDP proved to be efficacious, low-dose CDDP and 5-FU will have a role for patients with head and neck squamous cell carcinoma" 02/15/1995 - "CONCLUSION: The concurrent chemoradiotherapy using protracted low-dose continuous infusion of 5-FU and standard radiotherapy is an effective and safe method to obtain a local control in inoperable esophageal squamous cell carcinoma." Order ALL the reference details at left...
3.	Paclitaxel (Taxol)FDA LinkGeneric 07/01/2008 - "Improved local control by surgery and paclitaxel-based chemoradiation for esophageal squamous cell carcinoma: results of a retrospective non-randomized study." 02/01/2006 - "This study was designed to examine the relationship between cell-cycle phases of paclitaxel-activated checkpoints and to elucidate the molecular pathway of the effect of paclitaxel in human esophageal squamous cell carcinoma (ESCC) cell lines" 03/01/2005 - "This study evaluated the effects of a combination of opioid growth factor (OGF) and paclitaxel on squamous cell carcinoma of the head and neck (SCCHN) using a tissue culture model of human SCCHN" 12/15/2004 - "EXPERIMENTAL DESIGN: In the present study, we investigated the effects of 2ME2 alone and in combination with paclitaxel, an active agent in recurrent or advanced head and neck squamous cell carcinoma" 01/01/2004 - "Phase II evaluation of 96-hour paclitaxel infusion in advanced (recurrent or metastatic) squamous cell carcinoma of the head and neck (E3395): a trial of the Eastern Cooperative Oncology Group." Order ALL the reference details at left...
4.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/1997 - "Bleomycin (BLM) is a natural antibiotic, toxic to dividing cells (G2/M-phase), also proven effective in squamous cell carcinomas (SCC)" 01/01/1991 - "Bleomycin, an antitumor antibiotic, was effective in temporarily reducing the size of a metastatic squamous cell carcinoma in a ferret" 07/01/1978 - "The combination of cis-DDP and bleomycin is useful in the treatment of patients with squamous cell carcinoma of the esophagus." 11/01/2005 - "OBJECTIVES: To determine the safety and efficacy of electroporation with bleomycin in patients with advanced squamous cell carcinoma of the head and neck" 05/01/1997 - "Thus the antitumor effects of bleomycin in mice can be considerably potentiated by local electric pulses, suggesting that electrochemotherapy with bleomycin may have promise for treatment of vulvar or ectocervical squamous cell carcinomas with early invasion." Order ALL the reference details at left...
5.	Interleukin-2 (IL2)IBA 02/01/2003 - "OBJECTIVE: To assess the efficacy of combination therapy with IL-2 gene transfer and radiation in an immunocompetent murine model that parallel more closely the clinical therapy of head and neck Squamous cell carcinoma(HNSCC)" 01/01/1990 - "Cytolytic activation of peripheral blood lymphocytes by recombinant interleukin-2 (rIL-2) in patients with squamous cell carcinoma (SCC) of the head and neck may be inhibited by serum blocking factors, and this could influence therapeutic efficacy" 07/01/1989 - "The data obtained indicate that local adoptive immunotherapy with IL-2 and an adequate dose of LAKc may be effective in preventing the in vivo growth of established squamous cell carcinomas of the head and neck." 05/15/1990 - "The efficacy of local adoptive immunotherapy with human lymphokine-activated killer cells and recombinant interleukin 2 (rIL-2) in growth inhibition of established squamous cell carcinoma of the head and neck (SCCHN) was evaluated in a nude mouse model" 07/01/2002 - "BACKGROUND: The current randomized, multicenter, Phase III trial was conducted to determine whether the disease free interval and overall survival of patients with T2-T4,N0-N3,M0 squamous cell carcinoma (SCC) of the oral cavity or oropharynx could be extended through the combination of surgery (and radiotherapy, if required) with perilymphatic recombinant IL-2 (rIL-2)" Order ALL the reference details at left...
6.	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/01/1997 - "The statistically and clinically significant improvement in local regional relapse and cause-specific survival obtained support the use of mitomycin as an adjunct to radiation therapy in the management of squamous cell carcinoma of the head and neck." 06/01/1985 - "Our study does, however, provide additional evidence that mitomycin C-containing regimens may be selectively effective for squamous-cell carcinoma of the lung." 01/01/1997 - "CONCLUSION: The bioreductive alkylating agent mitomycin is a safe and effective adjunct to radiation therapy in the treatment of squamous cell carcinoma of the head and neck" 05/01/2005 - "PURPOSE: To demonstrate the efficacy of topical 0.002% mitomycin C (MMC) as an adjunctive and alternative treatment in primary and recurrent conjunctival-corneal intraepithelial neoplasia (CCIN) and squamous cell carcinoma (SCC)" 05/01/2002 - "PURPOSE: To evaluate the efficacy of topical mitomycin C for extensive recurrent conjunctival and corneal squamous cell carcinoma (SCC)" Order ALL the reference details at left...
7.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 07/01/2008 - "Novel targeted agents, such as epidermal growth factor receptor antagonists, are showing promise in the treatment of patients with both loco regionally advanced and recurrent/metastatic squamous cell carcinoma of the head and neck." 01/01/2008 - "Novel targeted agents, such as epidermal growth factor receptor antagonists, are showing promise in the treatment of patients with both locoregionally advanced and recurrent/metastatic squamous cell carcinoma of the head and neck." 06/01/2008 - "The purpose of this study was to determine whether the efficacy of taxoid treatment combined with epidermal growth factor receptor (EGFR) inhibition is dose and sequence dependent in head and neck squamous cell carcinoma" 06/01/2007 - "OBJECTIVE: To study the expressions of epidermal growth factor receptor (EGFR), C-erbB2 and Ki-67 in nasal squamous cell carcinomas (SCC) and investigate their clinicopathological significances in pathogenesis and development of this disease" 08/01/2005 - "OBJECTIVE: The purpose of this study was to invest the effect of epidermal growth factor receptor monoclonal antibody MAb225 on radiosensitivity of tongue squamous cell carcinoma cell Tca8113" Order ALL the reference details at left...
8.	Carboplatin (JM8)FDA LinkGeneric 08/01/2007 - "In the present study, the expression of a series of markers of chemo- and/or radio-resistance was investigated in 21 patients with advanced squamous cell carcinoma of the head and neck treated with combined intra-arterial carboplatin and radiotherapy" 12/01/2006 - "The aim of this study was to evaluate the usefulness of targeted intra-arterial carboplatin chemoradiotherapy in allowing less invasive surgery for patients with oral and oropharyngeal squamous cell carcinoma" 06/05/2006 - "In the clinical study, we evaluated 19 patients with squamous cell carcinomas of the oral cavity and oropharynx, who had undergone targeted carboplatin i.a" 02/01/2006 - "Carboplatin and hypofractionated accelerated radiotherapy: a dose escalation study of an outpatient chemoradiation schedule for squamous cell carcinoma of the head and neck." 12/01/1999 - "PATIENTS AND METHODS: In a phase II/III-trial fifty patients with advanced squamous cell carcinoma of the head and neck were treated by simultaneously accelerated radiochemotherapy with Carboplatin (70 mg/sqm)" Order ALL the reference details at left...
9.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2000 - "We report a 63-year-old man with an in situ squamous cell carcinoma located on a chronic radiodermitis area in a finger, treated successfully with PDT" 04/01/2005 - "ATX-S10(Na) PDT more effectively eliminated UVB-induced AK and squamous cell carcinoma (SCC) than ALA PDT" 02/01/2007 - "Further studies are now required to confirm these results and to examine the effect of treating epidermal dysplasia with PDT on subsequent development of squamous cell carcinoma in this high risk population." 12/01/2006 - "A series of human keratinocyte cell lines derived from human oral squamous cell carcinomas (OSCC) were used as the PDT 'targets' in this study" 09/01/2002 - "In this study, we have used the mouse SCCVII squamous cell carcinoma model to investigate the activity of neutrophils in tumours treated by PDT" Order ALL the reference details at left...
10.	cetuximab (Erbitux)FDA Link 11/01/2003 - "Promising results have also been obtained from the first clinical trial with cetuximab and radiotherapy in squamous-cell carcinoma of the head and neck" 06/20/2006 - "PURPOSE: This was an open, randomized, multicenter, phase I/II study to investigate the safety and tolerability of cetuximab in the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN)" 03/01/2008 - "The population pharmacokinetics of cetuximab were characterized by nonlinear mixed effects modeling (NONMEM V) using a total of 912 concentrations from 143 patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck enrolled in 2 phase I/II studies" 06/01/2007 - "PURPOSE: In this randomized, phase III study, quality of life (QoL) was assessed in patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN) after high-dose radiotherapy alone or in combination with cetuximab" 02/01/2002 - "An ongoing phase III international multicenter, randomized study in locally advanced squamous cell carcinoma of the head and neck is evaluating therapeutic radiation therapy, either alone or in conjunction with IMC-C225" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/27/1988 - "Although surgical resection is the best treatment for squamous cell carcinoma, new trends in pre-operative chemotherapy should provide better results" 02/01/1994 - "Lack of survival advantage in patients with advanced squamous cell carcinomas of the oral cavity receiving neoadjuvant chemotherapy prior to local therapy, despite achieving an initial high clinical complete remission rate." 03/01/1992 - "Eight patients are alive and disease free at more than three years from surgery, and all of these patients had a squamous cell carcinoma, and all had a complete histological response from their preoperative radiotherapy and chemotherapy." 09/01/1989 - "Although newer combined modality approaches, including neoadjuvant cytotoxic chemotherapy, for patients with squamous cell carcinoma (SCCA) of the head and neck have produced high initial complete response rates, they have not improved overall survival for patients with advanced disease" 06/01/2007 - "The survival rates of patients with squamous cell carcinoma of the head and neck (SCCHN) have not improved significantly despite multimodality therapy including surgery, radiation therapy, and chemotherapy" Order ALL the reference details at left...
2.	Neck Dissection (Radical Neck Dissection) 09/01/2007 - "SIGNIFICANCE: Planned neck dissection following definitive radiotherapy or chemoradiation is highly effective in achieving regional control of squamous cell carcinoma of the base of the tongue." 07/01/1994 - "CONCLUSION: Routine bilateral neck dissection is beneficial in the surgical management of squamous cell carcinoma of the supraglottic larynx." 07/01/1997 - "BACKGROUND: The efficacy of extending the application of selective neck dissection to include more-extensive neck disease in patients with squamous carcinoma of the upper aerodigestive tract remains controversial" 05/01/2006 - "The purpose of this study is to evaluate the efficacy of the lateral neck dissection (LND) for elective treatment of the clinically node negative neck (cN0) in laryngeal squamous cell carcinoma (SCC)" 10/01/2002 - "OBJECTIVE: The purpose of this study was to evaluate the efficacy of selective neck dissection (SND) for elective treatment of the clinically negative neck in head and neck squamous cell carcinoma (SCC)" Order ALL the reference details at left...
3.	Combination Drug Therapy (Combination Chemotherapy) 09/01/1988 - "Combination chemotherapy sandwiched with irradiation appears to be effective in the treatment of patients with recurrent squamous cell carcinoma of the esophagus" 12/01/2007 - "The present study suggests that combination chemotherapy with S-1 and DOC is an effective and safe regimen in NAC for oral squamous cell carcinomas." 01/01/1980 - "Safe and effective combination chemotherapy for squamous cell carcinomas of the head and neck." 04/01/1981 - "Randomized trials are needed to confirm or disprove the efficacy of combination chemotherapy for advanced squamous carcinoma of the head and neck." 10/01/1990 - "Anti-oncogram-oriented polychemotherapy in metastasizing squamous cell carcinoma of the skin: impressive partial remission]" Order ALL the reference details at left...
4.	Heterologous Transplantation (Xenotransplantation) 12/01/1995 - "We, therefore, performed an in vivo study to determine the efficacy of the combination of these two drugs using two human head and neck squamous cell carcinoma xenograft lines, subcutaneously growing in athymic nude mice" 05/01/1996 - "A nude mouse xenograft model of squamous cell carcinoma of the head and neck was used to investigate the in vivo efficacy of the repeated gene therapy interventions" 05/01/2008 - "In vivo studies showed that the inhibitory rates on laryngeal squamous carcinoma xenograft model were 32.43%, 43.24% and 70.27% for lower, moderate and higher dosage group, respectively" 12/01/2006 - "STUDY DESIGN: A human head and neck squamous cell carcinoma (HNSCC) xenograft model in nude rats was established via subcutaneous inoculation of a human-origin HNSCC cell line, SCC-4" 02/15/2005 - "The aim of this study was to generate a panel of head and neck squamous cell carcinoma (HNSCC) cell lines and xenografts of FA HNSCC, and to characterize these cell lines in comparison with a panel of seven cell lines from patients with sporadic HNSCC" Order ALL the reference details at left...
5.	Lymph Node Excision (Lymph Node Dissection) 03/01/1997 - "These results suggest that immediate radical surgery with lymph-node dissection is the best treatment for squamous cell carcinoma of the penis." 12/01/1995 - "PURPOSE: We determined whether an extended sentinel lymph node dissection is effective for staging penile squamous carcinoma associated with clinically negative inguinal lymph nodes" 03/01/1996 - "BACKGROUND: The efficacy of postoperative irradiation of the neck after lymph node dissection in terms of prevention of cervical node recurrence (NR) has not been demonstrated in patients with NO squamous cell carcinoma of the oral cavity" 04/01/2008 - "Isolated sentinel lymph node dissection with conservative management in patients with squamous cell carcinoma of the vulva: a prospective trial." 06/15/2005 - "BACKGROUND: The objective of the current study was to identify independent clinical and pathologic variables that were predictive of lymph node involvement in patients with squamous cell carcinoma of the penis in a multicenter series with the intent to select patients who were suitable to undergo immediate inguinal lymphadenectomy" Order ALL the reference details at left...

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