Methionyl Aminopeptidases

Aminopeptidases that remove METHIONINE from the amino-terminus of a peptide chain, such as the initiator METHIONINE found on nascent peptide chains.

Also Known As:

Methionyl Aminopeptidase; N-Terminal Methionine-Specific Peptidase; Peptidase M; Aminopeptidase, Methionyl; Aminopeptidases, Methionyl; Methionine-Specific Peptidase, N-Terminal; N Terminal Methionine Specific Peptidase

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Exopeptidases: 68
        Aminopeptidases: 708
        Methionyl Aminopeptidases: 4
        human METAP2 protein
        mouse Metap2 protein

Experts

1.	Feng, Yukuan: 1 article (01/2021)
2.	Gao, Shuangshu: 1 article (01/2021)
3.	He, Yan: 1 article (01/2021)
4.	Jin, Xiaoming: 1 article (01/2021)
5.	Li, Jing: 1 article (01/2021)
6.	Li, Qi: 1 article (01/2021)
7.	Li, Xiaobo: 1 article (01/2021)
8.	Li, Zhiwei: 1 article (01/2021)
9.	Qiao, Yu: 1 article (01/2021)
10.	Wang, Chuhan: 1 article (01/2021)

Related Diseases

1.	Chronic Renal Insufficiency 11/01/1989 - "The excretion profiles of the following marker proteins of glomerular and tubular origin were studied in patients suffering from chronic renal disease (GN, N = 36, GFR: 8 to 120 ml/min/1.73 m2): angiotensinase A (ATA), a glomerular endothelial glycoprotein, tubular ala(-leu-gly)-amino-peptidase-M (APM), gamma-glutamyl transpeptidase (GGT), and the major brush border surface glycoprotein (SGP-antigen) of 240 kD. "
2.	Severe Acute Respiratory Syndrome 11/11/2005 - "The main peptidase (M(pro)) from the coronavirus (CoV) causing severe acute respiratory syndrome (SARS) is one of the most attractive molecular targets for the development of anti-SARS agents. "
3.	Starvation 10/01/2006 - "Maltase, alkaline phosphatase, and amino peptidase M activities, determined in homogenates of the small intestinal mucosa (per g of the tissue) after 2 weeks of protein starvation, were lower in the rats of group 1 in comparison with the rats of group 2, kept on the standard diet. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "Mechanistically, we revealed that methionyl aminopeptidase 2 (METAP2) is one of the up-regulated metastasis regulators upon over-expression of non-coding LIN28A identified by mass spectrum, and confirmed that it is non-coding LIN28A mRNA instead of LIN28A protein promotes the expression of METAP2. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)
3.	Messenger RNA (mRNA)
4.	Membrane Glycoproteins (Membrane Glycoprotein)
5.	Glycoproteins (Glycoprotein)
6.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
7.	Antigens
8.	alpha-Glucosidases (Acid Maltase)
9.	Alkaline Phosphatase
10.	glycylleucine (Leu-Gly)