Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)

A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.

Also Known As:

Networked: 135 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Llorens-Cortes, Catherine: 15 articles (01/2022 - 05/2004)
2.	Marc, Yannick: 11 articles (01/2022 - 05/2008)
3.	Mizutani, Shigehiko: 11 articles (11/2013 - 11/2002)
4.	Balavoine, Fabrice: 10 articles (01/2022 - 05/2008)
5.	Larrinaga, Gorka: 6 articles (01/2017 - 02/2007)
6.	Mizutani, S: 6 articles (03/2015 - 01/2000)
7.	Ramírez-Expósito, María Jesús: 5 articles (01/2019 - 10/2011)
8.	López, José I: 5 articles (01/2017 - 02/2007)
9.	Perez, Itxaro: 5 articles (01/2017 - 11/2011)
10.	Nomura, Seiji: 5 articles (09/2008 - 11/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2019 - "Our results support the development of hypertension treatments targeting brain aminopeptidase A." 01/01/2019 - "These findings identified brain aminopeptidase A as a potential new therapeutic target for hypertension. " 01/01/2019 - "NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension." 08/01/2014 - "A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors." 01/01/2014 - "[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension]."
2.	Pre-Eclampsia (Preeclampsia) 03/01/1996 - "In conclusion this study demonstrates for the first time that increased villous trophoblastic angiotensinase A activity indicates an increased likelihood of the presence of pre-eclampsia and the severity of hypertensive disorders in pregnancy." 03/01/2021 - "Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis." 03/01/1996 - "Enhanced villous trophoblastic angiotensinase A activity was significantly associated with an increased frequency of pre-eclampsia in pregnant women (cumulative odds ratio x 0(1) 6.37; P < 0.001) and showed significant correlations with the severity of gestational hypertensive disorders, represented by systolic (r = 0.31; P < 0.05) and diastolic (r = 0.34; P < 0.05 blood pressure and by concomitant proteinuria (r = 044; P < 0.01). " 01/01/1987 - "Serum aminopeptidase A (AAP) activity was measured in normal pregnancy and pre-eclampsia. " 01/01/1987 - "Serum aminopeptidase A (AAP) in normal pregnancy and pregnancy complicated by pre-eclampsia."
3.	Premature Obstetric Labor (Premature Labor) 11/01/2013 - "The authors conclude that both aminopeptidase A and placental leucine aminopeptidase could be potentially safe and effective drugs for patients and their babies in the treatment of preeclampsia and preterm labor." 01/01/2011 - "Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia." 03/01/2015 - " changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction"
4.	Neoplasms (Cancer) 05/01/2000 - "Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression." 12/01/2019 - "Although involved in diverse cancer processes, the function of aspartyl aminopeptidase (DNPEP) in breast cancer remains elusive. " 11/12/2010 - "Aminopeptidase A (APA; EC 3.4.11.7) is a transmembrane metalloprotease with several functions in tumor angiogenesis. " 02/01/2004 - "We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. " 10/01/1978 - "When cultured mouse fibroblast strain C3H2K and rat fibroblast strain 3Y1 cells were transformed by SV40 or by a ts A mutant and maintained at permissive temperature, aminopeptidase A activity was drastically decreased, and the ratio of aminopeptidase A to aminopeptidase B was reduced to the levels of tumor cells. "
5.	Obesity 03/01/2017 - "These findings improve our comprehension about obesity-related hypertension and suggest new tools for its treatment.NEW & NOTEWORTHY In this study, we reported an increased angiotensin III generation in the circulation of ob/ob mice caused by a high aminopeptidase A activity. " 01/01/2018 - "The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as potential biomarkers of renal injury and fibrosis in an experimental model of obesity. "

Related Drugs and Biologics

1.	leucyl-cystinyl aminopeptidase
2.	Endothelin Receptor Antagonists
3.	Sodium-Glucose Transport Proteins
4.	Cytochrome P-450 CYP11B2 (CYP11B2)
5.	Mineralocorticoid Receptor Antagonists
6.	Enzymes
7.	CD13 Antigens (Alanine Aminopeptidase)
8.	Angiotensin III
9.	firibastat
10.	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)

Related Therapies and Procedures

1.	Denervation
2.	Surgical Instruments (Clip)
3.	Neoadjuvant Therapy
4.	Therapeutics
5.	Aftercare (After-Treatment)