|1.||Cruz, Deu John M: 2 articles (01/2015 - 01/2013)|
|2.||Boger, Dale L: 2 articles (08/2014 - 07/2008)|
|3.||Fenteany, Gabriel: 2 articles (11/2012 - 11/2002)|
|4.||Zheng, Wei: 1 article (12/2015)|
|5.||Tanega, Cordelle: 1 article (12/2015)|
|6.||Yi, Guanghui: 1 article (12/2015)|
|7.||Liang, T Jake: 1 article (12/2015)|
|8.||Kao, C Cheng: 1 article (12/2015)|
|9.||Zhang, Ya-Qin: 1 article (12/2015)|
|10.||Southall, Noel: 1 article (12/2015)|
05/01/2013 - "Furthermore, our study suggested that RAW cells maybe a simple and cost-effective model cell system to screen small molecule libraries to identify compounds that are effective in reducing RSV-induced inflammation."
01/01/2009 - "In addition, application of cell based assays simultaneously permits entry level evaluation of compound toxicity and endows with a powerful approach to perform high-throughput screenings of, e.g., small molecule libraries in a quest for novel compounds capable of influencing the inflammation process."
01/01/2009 - "The utility of these versatile assay components and their application for screening strategies was validated for all ten human Caspases, a family of intracellular proteases involved in cell death and inflammation, including implementation of assays for high throughput screening (HTS) of chemical libraries and functional screening of cDNA libraries. "
10/28/2013 - "We have explored the potential to complement NMR-based biophysical screening of chemical libraries with molecular docking in FBLD against the A(2A) adenosine receptor (A(2A)AR), a drug target for inflammation and Parkinson's disease. "
09/15/2006 - "This study suggests that screening of chemical libraries on cancer cells with defined mutations in apoptotic key elements can lead to the identification of compounds that are useful to characterize alternative pathways of caspase activation."
07/23/2009 - "Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. "
04/21/2009 - "The availability of large-scale synthetic low-molecular-weight chemical libraries has allowed HTS for compounds synergistic lethal with defined human cancer aberrations in activated oncogenes or tumour suppressor genes. "
02/15/2009 - "In contrast, nontargeted therapies are drugs identified by phenotypic screening of natural products or chemical libraries against established cancer cell lines or preclinical animal models without a priori knowledge of the target. "
12/01/2002 - "We report a new cell-based high-throughput technology for screening chemical libraries against several potential cancer target genes in parallel. "
12/01/2015 - "In this study, we performed a quantitative high throughput screening of the Molecular Libraries Small Molecule Repository (MLSMR) of ∼350,000 chemicals for novel HCV inhibitors using our previously developed cell-based HCV infection assay. "
08/01/2014 - "To address this situation, we used high-throughput screening (HTS) of synthetic small molecule libraries to identify compounds that restrict Ad infection. "
06/01/2010 - "We used a virus/cell-based assay to screen diverse chemical libraries to identify small molecules that could act in synergy with OVs to destroy tumor cells that resist viral infection. "
04/22/2011 - "By screening chemical libraries in the RIKEN Natural Products Depository, we identified a 3-phenyl coumarin-based compound that inhibited the cell cycle arrest activity of Vpr in yeast and Vpr-dependent viral infection of human macrophages. "
|4.||Wounds and Injuries (Trauma)
11/01/2012 - "The results identify two small molecules of interest for analysis of wound repair and cytokinesis, reveal that these processes are more similar than often realized and reveal the potential power of low tech screens of small molecule libraries for analysis of complex cellular processe."
11/04/2002 - "We have developed a high-throughput assay for screening chemical libraries for compounds that affect cell sheet migration during wound closure in epithelial cell monolayers. "
04/27/2015 - "The therapeutic challenges in the treatment of tuberculosis demand multidisciplinary approaches for the identification of potential drug targets as well as fast and accurate techniques to screen huge chemical libraries. "
06/01/2013 - "Both methods allow for in vivo screening of chemical libraries, requiring only 0.1 μmol of drug per fish to assess efficacy; they also permit a more detailed evaluation of the individual stages of tuberculosis pathogenesis. "
|2.||Amyloid Precursor Protein Secretases (beta-Secretase)
|3.||Galanin Receptors (Galanin Receptor)
|5.||Purinergic P1 Receptors (Adenosine Receptor)
|9.||Peptide Hydrolases (Proteases)
|3.||Drug Therapy (Chemotherapy)