Epidemic Louse-Borne Typhus (Typhus)

Subscribe to Selected New Research on Epidemic Louse-Borne Typhus

354 relevant articles (5 outcomes, 20 trials/studies) found for this Disease

Description: The classic form of typhus, caused by RICKETTSIA PROWAZEKII, which is transmitted from man to man by the louse Pediculus humanus corporis. This disease is characterized by the sudden onset of intense headache, malaise, and generalized myalgia followed by the formation of a macular skin eruption and vascular and neurologic disturbances.

Also Known As:

Typhus; Typhus, Epidemic Louse Borne; Brill's Disease; Typhus, Epidemic Louse-Borne; Brill Disease; Brill Zinsser Disease; Brills Disease; Disease, Brill; Disease, Brill's; Disease, Brill-Zinsser; Louse-Borne Typhus, Epidemic; Brill-Zinsser Disease

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Bacterial Infections: 6830

Gram-Negative Bacterial Infections: 240

Rickettsiaceae Infections: 9

Rickettsia Infections: 9

Epidemic Louse-Borne Typhus: 354

Related Diseases

1.	Endemic Flea-Borne Typhus (Typhus, Endemic Flea Borne)
2.	Scrub Typhus (Typhus, Scrub)
3.	Scabies (Sarcoptic Mange)
4.	Lice Infestations (Pediculosis)
5.	Lung Abscess

Experts

1.	Walker, D H: 2 articles (12/2001 - 09/2000)
2.	Feng, H M: 2 articles (12/2001 - 09/2000)
3.	Popov, V L: 2 articles (12/2001 - 09/2000)
4.	Luan, Ming-chun: 1 article (08/2007)
5.	Zhang, De-rong: 1 article (08/2007)
6.	Zhang, Li-juan: 1 article (08/2007)
7.	Di, Ying: 1 article (08/2007)
8.	Fu, Xiu-ping: 1 article (08/2007)
9.	Zhang, Jing-shan: 1 article (08/2007)
10.	Li, Xue-mei: 1 article (08/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Epidemic Louse-Borne Typhus:

1.	Chloramphenicol (Chloromycetin)FDA Link 12/01/1967 - "[The efficacy of levomycetin in treating patients with typhus abdominalis]" 10/01/1973 - "I. Multiplication of typhus rickettsiae in human macrophage cell cultures in the nonimmune system: influence of virulence of rickettsial strains and of chloramphenicol." 11/01/1965 - "[Influence of chloramphenicol on the reactivity and adaptation of interoceptive reflexes following perfusion of intestinal interoceptors with typhus endotoxin]" 10/01/1956 - "[Application of levomycetin in tick typhus.]" 11/01/1955 - " II. Effect of synthomycetin and levomycetin on the course of experimental typhus exanthematosus in guinea pigs.]" Order ALL the reference details at left...
2.	AntigensIBA 01/01/1995 - "Serological studies of the antigenic similarity between typhus group rickettsiae and Weil-Felix test antigens." 08/01/2000 - "These data as well as the data of other investigators show that serodiagnostics of epidemic typhus using recombinant antigens remains a problem." 08/01/2000 - "[Characteristics of recombinant fragments of the protective antigen SPA of epidemic typhus pathogens]" 03/01/1997 - "A definite diagnosis of epidemic typhus caused by Rickettsia prowazekii was established by enzyme-linked immunosorbent assay using specific antigens. " 01/01/1997 - "On the other hand, a typhus group rickettsia demonstrated no antigens cross-reactive to the PS120 of SFG rickettsiae." Order ALL the reference details at left...
3.	DDTIBA 07/01/2005 - "A lost chapter in the early history of DDT: the development of anti-typhus technologies by the Rockefeller Foundation's Louse Laboratory, 1942-1944." 04/01/1999 - "DDT, a pesticide, was first used in the 1940s to control wartime typhus and agricultural pests. " 02/01/1946 - "Control of Typhus in Italy 1943-1944 by Use of DDT." 06/01/1998 - "These efforts culminated in the world's first field trial of DDT against louse-borne typhus and later as a residual spray for malaria. " 07/30/1948 - "Combined typhus-malaria control residual spray operations with five percent DDT emulsion." Order ALL the reference details at left...
4.	Membrane Proteins (Integral Membrane Proteins)IBA 02/01/2005 - "The presence of the nucleic acid of the spotted fever group (SPG) and typhus group (TG) rickettsiae was investigated in 200 serum specimens seropositive for SFG rickettsiae by multiplex-nested polymerase chain reaction with primers derived from the rickettsial outer membrane protein B gene. " 09/01/1978 - "Surface proteins of typhus and spotted fever group rickettsiae." 11/01/2004 - "The outer membrane protein B (OmpB) of the typhus group rickettsiae is an immunodominant antigen and has been shown to provide protection against typhus in animal models. " 01/01/1987 - "Analysis of 15 spotted fever group (SFG) and 2 typhus group strains of rickettsiae with a panel of monoclonal antibodies revealed a number of shared and unique epitopes of the 120- and 155-kilodalton surface proteins. " 11/06/1995 - "We have isolated an Arabidopsis thaliana cDNA encoding a highly hydrophobic membrane protein of 589 amino acids which contains 12 potential transmembrane helices and shows a high degree of similarity (43.5% identity, 66.2% similarity) to the ATP/ADP translocase of the Gram-negative bacterium Rickettsia prowazekii, an obligate intracellular parasite responsible for the epidemic typhus. " Order ALL the reference details at left...
5.	Doxycycline (Vibramycin)FDA LinkGeneric 09/28/1974 - "Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus." 07/01/1987 - "Doxycycline has emerged as the best treatment for murine typhus, epidemic typhus, and scrub typhus. " 05/01/1987 - "Aortic and mitral valve replacement surgery and a 6-week course of doxycycline therapy produced a clinical cure in this patient, as well as a diagnostic fall in markedly elevated preoperative typhus indirect fluorescent antibody (IFA) and complement fixation (CF) titers. " 08/01/1975 - "Treatment of louse-borne typhus fever with chloramphenicol, tetracycline or doxycycline." Order ALL the reference details at left...
6.	VaccinesIBA 04/01/1975 - "[New laboratory test for the study of post-vaccination immunity and evaluation of the protective capacity of intestinal typhus vaccines]" 11/01/1950 - "Studies on commercial typhus vaccines. " 11/01/1950 - "Studies on commercial typhus vaccines. " 11/01/1950 - "Studies on commercial typhus vaccines. " 11/01/1950 - "Studies on commercial typhus vaccines. " Order ALL the reference details at left...
7.	Complement System Proteins (Complement)IBA 05/01/1994 - "Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting." 09/01/1972 - "Fluorescent antibody complement fixation test as a serodiagnostic method in the Brill-Zinsser disease." 02/28/1962 - "[Complement fixing antibody against typhus group Rickettsiae in sera of healthy Korean.]" 01/01/1958 - "[Effect of non-specific stimulus on complement fixation reactions in typhus convalescents.]" 08/01/1957 - "[Serologic typing of typhus with the aid of complement fixation reaction.]" Order ALL the reference details at left...
8.	AntibodiesIBA 06/01/2008 - "We tested sera from 176 homeless people in Houston for antibodies against typhus group rickettsiae (TGR). " 03/01/2004 - "Typhus group Rickettsiae antibodies in rural Mexico." 05/01/2000 - "The increasing prevalence of Endemic Typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi." 05/01/1994 - "prowazekii was found to be similar during primary and recrudescent typhus, and all sera examined contained antibodies to the same R. " 01/01/1994 - "The protective role of antibodies evaluated by the solid-phase fluorescent enzyme immunoassay in typhus immunity has been shown." Order ALL the reference details at left...
9.	Immunoglobulin M (IgM)IBA 01/01/2005 - "There was a significant correlation between serum TCII levels and typhus IgM or IgG titers (p < 0.05), but not to total IgM levels. " 01/01/2005 - "Only a few epidemic typhus positive sera contained IgM antibodies. " 12/01/2002 - "Of 30 patients with exposure to tick typhus, 4 (13.3%) were IgM positive and 1 (3.3%) was IgG positive. " 03/01/1995 - "A prevalence of IgM antibodies to Proteus OX 19, Proteus OX 2, to the Rickettsia typhus group, to Legionella pneumophila serovars 4 and 5, to L. " 04/01/1990 - "Among sera of patients suffering from typhus, 100% were positive for IgG and 78.9% for IgM. " Order ALL the reference details at left...
10.	Erythromycin (Erycette)FDA LinkGeneric 08/01/2005 - "OBJECTIVES: Typhus group (TG) rickettsiae are naturally susceptible to erythromycin whereas spotted fever group (SFG) rickettsioses are not. " 11/03/1984 - "Because of the occasional need for an alternative drug for the treatment of tick-bite fever, a study of the value of erythromycin for the variety of tick-borne typhus fever occurring in southern Africa was undertaken. " 12/01/2005 - "Apart from the mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species previously reported by our team, we found that typhus group (TG) rickettsiae had a triple amino acid difference in the highly conserved region of the L22 ribosomal protein as compared to the spotted fever group rickettsiae (SFG), which could explain the natural resistance of SFG rickettsia to erythromycin. " 06/01/1978 - "It was shown that administration in the course of one week, before or after a single use of killed or chemical typhoid vaccine of dibiomycin, biomycin, or biomycin in combination with erythromycin in comparatively high doses produced no negative effect of the production of typhus antibodies and the intensity of antitoxic immunity in albino mice. " Order ALL the reference details at left...

Therapies and Procedures

1.	Chemoprevention 08/01/1978 - "Formation of typhus immunity was seen when such chemoprophylaxis scheme was followed." 05/01/1991 - "Prevention of rickettsial infections is aimed at individual control and epidemic measures (especially in epidemic typhus), vector and rodent control, milk pasteurization (in Q fever), chemoprophylaxis and immunoprophylaxis. " Order ALL the reference details at left...
2.	Injections 09/01/1961 - "[Immunization of man against typhus epidemics by injections of avirulent Rickettsia prowazeki (CEPAE). " 06/01/1978 - " Plague and typhus shots often produce reactions, and the immunity is not always good, but injections are highly recommended for those travelling in the interior of affected areas. " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 01/01/1948 - "Typhus and chemotherapy." 02/01/1957 - "[A brief essay on the development of chemotherapy of malaria and recurrent typhus in Russia.]" Order ALL the reference details at left...
4.	X-Ray Film 03/01/1983 - "The x-ray film in typhus abdominalis in childhood shows the same signs as an adult x-ray. " Order ALL the reference details at left...
5.	Tracheotomy 04/01/1995 - "It was only after suitable cannulae had been introduced by Trousseau in 1851 (double cannula with removeable insert) that tracheotomy became a routine procedure, and it was immediately carried out in a great many cases of diphtheria, croup, typhus, and lues, which often caused critical dispnea. " Order ALL the reference details at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>