Terbinafine (Lamisil)

A naphthalene derivative that inhibits fungal SQUALENE EPOXIDASE and is used to treat DERMATOMYCOSES of the skin and nails.

Also Known As:

Lamisil; (E)-N-(6,6-Dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride; DA 5505; SF 86-327; SF-86-327; TDT-067; Terbinafine Hydrochloride; Terbinafine, (Z)-; Terbinafine, (Z)-isomer; SF 86 327; SF 86327; SF86327; TDT 067; TDT067; 1-Naphthalenemethanamine, N-((2E)-6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-

Networked: 1415 relevant articles (312 outcomes, 274 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gupta, Aditya K: 35 articles (12/2022 - 04/2002)
2.	Gupta, A K: 18 articles (03/2020 - 01/2000)
3.	Hiruma, Masataro: 10 articles (09/2021 - 01/2003)
4.	Kano, Rui: 10 articles (09/2021 - 08/2012)
5.	Nenoff, P: 9 articles (10/2021 - 04/2014)
6.	Tavakkol, Amir: 9 articles (07/2021 - 05/2005)
7.	Khurana, Ananta: 8 articles (11/2022 - 01/2018)
8.	Chowdhary, Anuradha: 7 articles (11/2022 - 07/2018)
9.	Sardana, Kabir: 7 articles (11/2022 - 11/2017)
10.	Monod, Michel: 7 articles (01/2022 - 01/2010)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 09/01/2004 - "The accepted regimen for terbinafine, one of the most effective treatments for dermatophyte onychomycosis, is continuous administration of 250 mg/day over 16 weeks. " 12/01/2016 - "Daily practice: Mikailov and al., challenge our habits by their medico economic study and propose an empirical treatment with terbinafine for patients with suspected onychomycosis that is cost effective with minimal effect on patient safety as terbinafine-induced liver injury is very rare. " 10/01/2009 - "Terbinafine is an excellent choice in diabetics due to its low risk of drug-drug interaction and proven efficacy against the typical pathogens that cause onychomycosis. " 03/01/2004 - "This review suggests that terbinafine is a safe and effective treatment for onychomycosis in high-risk populations. " 11/01/1995 - "High mycologic cure rates in onychomycosis of the toenail can be achieved by terbinafine by this novel treatment regimen."
2.	Infections 01/01/1999 - "The results of this study confirm that oral terbinafine is safe and highly effective for the short-term treatment of fungal skin infections." 11/15/2012 - "Terbinafine is the most frequently used systemic antimycotic and antifungal medication, reflecting its superior efficacy for dermatophyte infections. " 04/17/1999 - "Terbinafine is best treatment for fungal nail infection " 04/01/2015 - "Reduction in the immunosuppression and treatment with terbinafine cleared the P. romeroi infection, while lowering immunosuppression and changing the type of immunosuppressive therapy were important steps in the successful management of the KS. " 08/01/2012 - "Although bioavailability was low, excellent penetration at the site of infection and low minimum inhibitory concentrations values provided terbinafine with good efficacy against dermatophyte infections."
3.	Tinea (Ringworm) 02/01/1992 - "High cure rates have been obtained in a preliminary study with oral terbinafine, 0.25 g/d, for 12 months, which have cleared toenail tinea in 15 of 17 patients. " 10/01/2014 - "Our findings suggest that in vivo potency and efficacy of AS2077715 are equal to or greater than that of terbinafine, positioning AS2077715 as a good candidate for use in treating trichophytosis. " 11/12/2023 - "In summary, our study establishes TH-NEG as a promising carrier for terbinafine in treating dermatophytosis, offering improved drug delivery and sustained release potential." 03/01/2001 - "In the tinea corporis/cruris study, treatment was effective in 65% of the terbinafine group compared with 8% of the vehicle group (P < .001). " 11/01/2003 - "Terbinafine was found to be a well-tolerated and effective treatment of tinea of the skin and nails."
4.	Tinea Pedis (Athlete's Foot) 10/01/1990 - "We conclude that terbinafine is well tolerated and highly effective in moccasin-type tinea pedis." 01/01/2008 - "To study and establish an optimal administration method of oral antifungal, terbinafine (TBF), for hyperkeratotic type tinea pedis, from the pharmacokinetic point of view, 20 patients with hyperkeratotic type tinea pedis were given TBF 125 mg once daily for 4 weeks and observed over time for improvement in dermatological symptoms and mycological efficacy. " 01/01/2008 - "Thus, we conclude that the high efficacy of short-term treatment with terbinafine in patients with tinea pedis is possible due to its fungicidal activity coupled with a distinct reservoir formation in the upper layers of the epidermis." 10/01/1990 - "Results of mycologic tests and clinical findings showed terbinafine to be significantly more effective than placebo in the treatment of tinea pedis. " 03/01/2001 - "In the tinea pedis study, 66% of patients were effectively treated with terbinafine compared with 4% of the group treated by vehicle (P < .001; Mantel-Haenszel test). "
5.	Tinea Capitis 07/01/1996 - "In our opinion, terbinafine given for 1, 2 or 4 weeks, is equally effective for most cases of tinea capitis." 01/01/1999 - "Terbinafine was thought to be very effective and safe for kerion Celsi. " 10/01/2021 - "We conclude that both drugs were effective for the treatment of tinea capitis; however, lesions in those cases receiving terbinafine involuted more slowly." 11/01/2020 - "This preliminary study demonstrated that topical 1% encapsulated terbinafine hydrochloride gel was an effective treatment for tinea capitis in children." 11/01/2020 - "We evaluated the therapeutic efficacy, safety, and tolerability of topical 1% encapsulated terbinafine hydrochloride gel for the treatment of pediatric tinea capitis. "

Related Drugs and Biologics

1.	Itraconazole (Sporanox)
2.	Griseofulvin (Grifulvin V)
3.	Fluconazole (Zonal)
4.	Antifungal Agents
5.	Terbinafine (Lamisil)
6.	Allylamine
7.	Ketoconazole (Nizoral)
8.	Solutions
9.	posaconazole
10.	amorolfine

Related Therapies and Procedures

1.	Therapeutics
2.	Duration of Therapy
3.	Debridement
4.	Solid-State Lasers
5.	Gas Lasers