Itraconazole (Sporanox)

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1709 relevant articles (369 outcomes, 279 trials/studies) found for this Drug

Description: One of the triazole ANTIFUNGAL AGENTS that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ERGOSTEROL synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.

Also Known As:

Sporanox; R-51211; R 51211; R51211; 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Azoles: 224

Triazoles: 104

Itraconazole: 1709

hydroxyitraconazole: 3

cyclodextrin itraconazole: 2

Piperazines: 17

Itraconazole: 1709

hydroxyitraconazole: 3

cyclodextrin itraconazole: 2

Experts

1.	Gupta, A K: 13 articles (11/2006 - 07/2000)
2.	Glasmacher, Axel: 6 articles (01/2008 - 12/2003)
3.	De Beule, K: 6 articles (10/2001 - 07/2000)
4.	Lynde, C W: 5 articles (11/2006 - 03/2001)
5.	Wheat, L J: 5 articles (08/2001 - 06/2000)
6.	Connolly, P: 4 articles (08/2001 - 06/2000)
7.	Charles, Bruce G: 3 articles (04/2007 - 01/2006)
8.	Winston, Drew J: 3 articles (01/2007 - 09/2002)
9.	Mattiuzzi, Gloria N: 3 articles (01/2006 - 01/2003)
10.	Cortes, Jorge: 3 articles (01/2006 - 01/2003)

Related Diseases

1.	Infection 03/01/1989 - "It is a potent inhibitor of most human fungal pathogens including Aspergillus sp. In non-comparative clinical trials itraconazole was shown to be extremely effective in a wide range of superficial and more serious 'deep' fungal infections when administered once or twice daily" 09/01/1998 - "Additionally, studies have demonstrated that itraconazole may have increased efficacy and an excellent safety profile when administered in a pulse-dose, or intermittent fashion, for superficial mycotic infections" 12/01/2006 - "Itraconazole intravenously followed by oral capsules is thus tolerated and effective in severely ill patients with proven invasive fungal infection." 01/01/2003 - "The infection cleared after complete surgical excision and 6 months of oral itraconazole therapy" 09/01/1998 - "Itraconazole has proven efficacy in treating cutaneous and mucosal Candida infections" Get all the results and reference details, order at left...
2.	Onychomycosis (Tinea Unguium) 12/01/1998 - "In conclusion, intermittent itraconazole therapy is highly effective and safe in patients with onychomycosis." 09/01/2005 - "Itraconazole may be effective in the treatment of onychomycosis caused by F" 11/01/2003 - "CONCLUSION: Itraconazole was found to be effective, well-tolerated and safe therapy for disto-lateral subungual onychomycosis." 01/01/2000 - "Itraconazole is effective against Candida onychomycosis" 01/01/1999 - "Therapeutic efficacy and safety of one-week intermittent therapy with itraconazole for onychomycosis in a Chinese patient population." Get all the results and reference details, order at left...
3.	Aspergillosis 06/01/2006 - "Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis." 03/01/1994 - "The data indicate that itraconazole is highly effective in preventing true invasive aspergillosis" 04/01/2006 - "Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis" 10/01/1999 - "The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults)." 12/01/1995 - "Serum concentrations of the drug ranged from 2 micrograms/mL to 30 micrograms/mL. Review of 20 cases of cerebral aspergillosis that were treated with itraconazole revealed that three of the four patients who received high doses (800 mg/d in the adults) of the drug responded favorably, while only two of the 16 patients who received a dose of 400 mg/d were cured" Get all the results and reference details, order at left...
4.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/1997 - "CONCLUSIONS: Itraconazole cyclodextrin solution achieves higher serum itraconazole and hydroxy-itraconazole concentrations than the capsule formulation in AIDS patients, and this is associated with improved efficacy." 10/01/1999 - "Itraconazole solution can be effective in AIDS patients with C" 04/01/2001 - "DNA fingerprinting of serial Candida albicans isolates obtained during itraconazole prophylaxis in patients with AIDS." 04/01/1998 - "Therefore, the estimated minimum decrease of the mean AUC0-24 of itraconazole in phase 2 was approximately 88% compared with phase 1. The mean AUC0-24 was 1.07 vs 0.38 microg x h x ml(-1) in phase 1 and 2, respectively, in AIDS patients" 06/01/1997 - "METHODS: The pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole were assessed on days 1 and 7 of therapy in acquired immunodeficiency syndrome (AIDS) patients with oral candidosis taking either itraconazole solution or capsules and the serum concentrations (measured by high performance liquid chromatography) correlated with the clinical response to therapy" Get all the results and reference details, order at left...
5.	Candidiasis (Moniliasis) 12/01/2007 - "It is concluded that the efficacy of itraconazole in the treatment of the vaginal candidiasis under different immunity conditions (groups A, E and F) in mice were all good, but there was no difference in the anti-fungal effect of itraconazole among the three groups." 02/01/2007 - "CONCLUSIONS: Oral administration of itraconazole OS displayed therapeutic efficacy against murine oral and oesophageal candidiasis superior to that achieved by intragastric administration" 02/01/2007 - "In the oesophageal candidiasis model, oral administration of itraconazole OS displayed superior therapeutic efficacy to the intragastric route" 02/01/2007 - "Oral administration of itraconazole solution has superior efficacy in experimental oral and oesophageal candidiasis in mice than its intragastric administration." 11/01/1995 - "Early oral itraconazole is effective in disseminated candidiasis and well tolerated by children." Get all the results and reference details, order at left...
293 Diseases and 1709 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

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2.	Amphotericin B (Amphotericin)
3.	terbinafine (Lamisil)
4.	Ketoconazole (Nizoral)
5.	Griseofulvin (Grifulvin V)
6.	Flucytosine (Ancobon)
7.	voriconazole (Vfend)
8.	AmBisome (liposomal amphotericin B)
9.	Antifungal Agents
10.	posaconazole
292 Drugs and Important Bio-Agents and 992 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Stem Cell Transplantation
5.	Debridement
40 Therapies and Procedures and 145 more articles analyzed in the Research Interface, order at left...

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