Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafine.

Abstract

AS2077715 is a novel antifungal metabolite produced by the newly isolated fungal strain Capnodium sp. 339855. This compound has potent inhibitory activity against Trichophyton mentagrophytes mitochondrial cytochrome bc1 complex (complex III) and potent fungicidal activity against T. mentagrophytes, as measured in vitro. Here, we compared the effects of AS2077715 and terbinafine in a guinea pig model of tinea pedis. In a treatment regimen started from the day 7 after infection, 10 daily oral doses of 10 and 20 mg kg(-1) AS2077715 and 20 mg kg(-1) of terbinafine significantly decreased fungal colony-forming units (CFUs) in foot pad skin. In a treatment regimen started from the day 11 after infection, 20 mg kg(-1) AS2077715 significantly reduced fungal CFUs in foot pad skin after 7 daily doses in comparison with 20 mg kg(-1) terbinafine-treated guinea pigs. Our findings suggest that in vivo potency and efficacy of AS2077715 are equal to or greater than that of terbinafine, positioning AS2077715 as a good candidate for use in treating trichophytosis.

• Authors: Keisuke Ohsumi, Hidetsugu Murai, Ikko Nakamura, Masato Watanabe, Akihiko Fujie
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 67 Issue 10 Pg. 717-9 (Oct 2014) ISSN: 1881-1469 [Electronic] England
• PMID: 24865864 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Enzyme Inhibitors
• Naphthalenes
• Terbinafine

Topics

• Administration, Oral
• Animals
• Antifungal Agents (therapeutic use)
• Colony Count, Microbial
• Disease Models, Animal
• Enzyme Inhibitors (therapeutic use)
• Guinea Pigs
• Male
• Naphthalenes (therapeutic use)
• Skin (microbiology)
• Terbinafine
• Tinea Pedis (drug therapy)
• Treatment Outcome