Single dose pharmacokinetics of terbinafine in cats.

Abstract

The pharmacokinetics of terbinafine was studied in six healthy fasted cats following a single intravenous and oral administration at a dose of 10 mg/kg and 30 mg/kg, respectively, according to a two-period crossover design. Plasma terbinafine concentrations were determined using a reverse phase liquid chromatographic method. The pharmacokinetic parameters were calculated by non-compartmental analysis with WinNonlin 5.2.1 software. After intravenous administration, the terminal half-life and area under the curve from time 0 to infinity were 10.40 ± 4.56 h, 15.20 ± 3.61 h·µg/ml, respectively. After oral dosing, the mean maximum concentration was 3.22 ± 0.60 µg/ml, reached at 1.33 ± 0.41 h. The terminal half-life, area under the curve from time 0 to infinity and apparent volume of distribution were 8.01 ± 3.46 h, 13.77 ± 4.99 h·µg/ml, 25.63 ± 6.29 l/kg, respectively. The absolute bioavailability of terbinafine hydrochloride tablets after oral administration was 31.00 ± 10.85%. Although bioavailability was low, excellent penetration at the site of infection and low minimum inhibitory concentrations values provided terbinafine with good efficacy against dermatophyte infections.

• Authors: Ang Wang, Huanzhong Ding, Yiming Liu, Yan Gao, Zhenling Zeng
• Journal: Journal of feline medicine and surgery (J Feline Med Surg) Vol. 14 Issue 8 Pg. 540-4 (Aug 2012) ISSN: 1532-2750 [Electronic] England
• PMID: 22403416 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antifungal Agents
• Naphthalenes
• Tablets
• Terbinafine

Topics

• Administration, Oral
• Animals
• Antifungal Agents (administration & dosage, pharmacokinetics)
• Area Under Curve
• Cats (blood)
• Chromatography, High Pressure Liquid (veterinary)
• Cross-Over Studies
• Drug Administration Schedule (veterinary)
• Half-Life
• Naphthalenes (administration & dosage, pharmacokinetics)
• Tablets
• Terbinafine