Survivin

An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.

Also Known As:

Networked: 5441 relevant articles (249 outcomes, 1257 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Altieri, Dario C: 62 articles (01/2019 - 02/2002)
2.	Li, Fengzhi: 45 articles (01/2022 - 10/2002)
3.	Kanwar, Jagat R: 28 articles (01/2018 - 04/2010)
4.	Rödel, Franz: 26 articles (01/2022 - 08/2002)
5.	Safe, Stephen: 25 articles (05/2022 - 03/2007)
6.	Ling, Xiang: 24 articles (01/2022 - 03/2004)
7.	Li, Wei: 24 articles (11/2021 - 06/2006)
8.	Sato, Noriyuki: 22 articles (02/2020 - 06/2002)
9.	Torigoe, Toshihiko: 22 articles (02/2020 - 06/2002)
10.	Kanwar, Rupinder K: 22 articles (01/2018 - 12/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/20/2015 - "The anti-tumor effect was more effective for the highly malignant tumor xenografts with highly Survivin expression. " 06/01/2013 - "We demonstrated that the CArG-enhanced survivin promoter markedly improved the proliferative activity of the oncolytic adenovirus in HCC cells, thereby augmenting hSulf-1 expression and inducing cancer cell apoptosis. " 10/01/2018 - "Our results show that Survivin, CK19, and Yap have a diffuse (>75%) positive staining of tumor cells in the aggressive tumors compared with good outcome tumors. " 01/01/2018 - "The treatment results showed significant reduction of tumor weight by 44.3% (P < 0.05), accompanied by under-expression of survivin. " 12/01/2014 - "The labeling index of nuclear survivin was above 3 % in only 1 (2.6 %) of the 38 tumors of the non-smokers, while the labeling indices in 19 (43.2 %) of 44 tumors of the smokers were above 3 % with a significantly greater frequency. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 10/01/2012 - "Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer." 05/01/2006 - "As survivin is differentially expressed in bladder cancer and not in the normal urothelium, several studies have demonstrated efficacy of urine testing of survivin as a diagnostic tool for an early detection of bladder cancer. " 10/01/2005 - "The BTA stat, survivin assay, and urine cytology were unable to predict bladder cancer cases in our cohort of patients with SCI. Cystoscopy, therefore, remains the gold standard for bladder cancer surveillance in patients with SCI." 01/01/2022 - "The survivin spPLA showed a sensitivity of 30% and specificity of 89% for bladder cancer detection in this study of 110 bladder cancer cases and 133 clinical controls. " 09/01/2018 - "This study is a meta-analysis and aims to determine the value of urinary survivin for detecting bladder cancer (BC) on the basis of preceding statistical performance and to compare their diagnostic value. "
3.	Breast Neoplasms (Breast Cancer) 07/22/2010 - "Our studies suggest that new strategies targeting erbB3 or Survivin may enhance the efficacy of chemotherapeutic agents against erbB2-overexpressing breast cancer." 09/01/2019 - "Since survivin is involved in cell cycle and apoptosis, this study aims to investigate the effect of miR-214-3p on the proliferation and apoptosis of breast cancer cells. " 02/01/2019 - "Survivin expression was not associated with breast cancer recurrence in this study. " 01/01/2019 - "The aim of this study was to investigate the role of BIRC5 polymorphisms in breast cancer (BC) and to connect survivin expression with various clinicopathological characteristics of BC patients. " 01/01/2019 - "This study aimed to explore the potential association between survivin promotor gene -31G/C single nucleotide polymorphism (rs9904341) and its serum level alteration on one hand, and the risk of breast cancer in Egyptian patients on the other hand. "
4.	Melanoma (Melanoma, Malignant) 05/01/2006 - "Persistence of survivin specific T cells for seven years in a melanoma patient during complete remission." 12/01/1999 - "These data demonstrate that apoptosis inhibition by survivin may participate in the onset and progression of malignant melanomas, and suggest that therapeutic targeting of survivin may be beneficial in patients with recurrent or metastatic disease." 01/01/2021 - "Among the other tested genes, survivin/BIRC5 showed as well-promising results as a prognostic marker in canine melanoma. " 08/01/2014 - "Collectively, these studies establish that targeting survivin could provide an opportunity to treat melanoma patients." 01/01/2008 - "These studies suggest that compromise of either p53 or Rb pathways during melanocyte transformation leads to up-regulation of survivin expression in melanoma."
5.	Prostatic Neoplasms (Prostate Cancer) 03/15/2009 - "On multivariate analysis, nuclear survivin intensity scores >191.2 were significantly associated with improved overall survival (HR, 0.46; 95% CI, 0.25-0.86; p = 0.0156) and prostate cancer survival (HR, 0.36; 95% CI, 0.16-0.84; p = 0.0173). " 03/15/2009 - "Compared with patients with nuclear survivin intensity scores of <or=191.2, those with intensity scores >191.2 had significantly improved prostate cancer survival (hazard ratio [HR], 0.45; 95% confidence interval [CI], 0.20-1.00, p = 0.0452). " 03/15/2009 - "Nuclear overexpression of survivin was associated with improved overall and prostate cancer survival on multivariate analysis, and cytoplasmic overexpression of survivin was associated with increased rate of local progression on univariate analysis in patients with locally advanced prostate cancer treated on RTOG 8610. " 11/01/2014 - "Thus, inhibition of survivin expression, enhancement of ROS and NO level by CP or other similar pharmaceutical agents might be effective in lowering the malignant proliferation of human prostate cancer cells. " 02/16/2018 - "Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Peptides (Polypeptides)
5.	sepantronium
6.	Caspase 3 (Caspase-3)
7.	Antigens
8.	Docetaxel (Taxotere)
9.	Vaccines
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Radiotherapy
5.	Aftercare (After-Treatment)