Caspase 3 (Caspase-3)

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3509 relevant articles (83 outcomes, 330 trials/studies) found for this Bio-Agent

Description: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

Also Known As:

Caspase-3; Procaspase-3; Apopain; Pro-Caspase-3; Pro Caspase 3; Procaspase 3; CASP3

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Jing-Gung: 10 articles (11/2007 - 11/2004)
2.	Blomgren, K: 6 articles (03/2001 - 08/2000)
3.	Wang, X: 5 articles (03/2001 - 08/2000)
4.	Hagberg, H: 5 articles (03/2001 - 08/2000)
5.	Delivoria-Papadopoulos, Maria: 4 articles (06/2008 - 09/2002)
6.	Mishra, Om P: 4 articles (06/2008 - 09/2002)
7.	Choi, Yung Hyun: 4 articles (01/2008 - 11/2003)
8.	Lu, Hsu-Feng: 4 articles (11/2007 - 05/2006)
9.	Yang, Jai-Sing: 4 articles (11/2007 - 10/2006)
10.	Robertson, G S: 4 articles (08/2006 - 04/2000)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2003 - "These results indicate that therapeutic attempts to induce caspase-3 in malignant cells may prove useful in the treatment of bcl-x(L)-expressing tumors." 01/01/2000 - "CONCLUSIONS: These findings suggest that caspase-3 may mediate apoptosis induced by CDDP, and its induction could represent a novel approach to the effective treatment of malignant tumors." 02/01/2005 - "The sequential treatment of mice with chemotherapeutic drugs followed by TRAIL induced caspase-3 activity, and apoptosis, inhibited angiogenesis, completely eradicated the established tumors, and enhanced survival of mice. " 09/15/2004 - "The sequential treatment of xenografted mice with irradiation followed by TRAIL-induced apoptosis through activation of caspase-3, induction of Bax and Bak, and inhibition of Bcl-2, and completely eradicated the established tumors with enhanced survival of nude mice. " 07/10/2005 - "The ZAC-mediated apoptosis signal is p53-independent and eliminated by inhibitors of caspase 3, 8 and 9. Reduced expression of ZAC would therefore favor tumor progression. " Order ALL the reference details at left...
2.	Ischemia 10/01/2004 - "This study aimed at investigating the correlation between the change of ischemic neuronal injury and Caspase-3 post-ischemia in human hippocampus. " 11/27/2001 - "In the present study, we examined if cerebral ischemic tolerance induced by sublethal ischemia is associated with an attenuation of caspase-3 activation in a mouse forebrain ischemia model. " 11/01/2001 - "This study was designed to demonstrate that intermittent ischemia could improve postischemic survival rates by a decrease of JNK(1)/SAPK(1) and caspase 3 activation, which were involved in the apoptosis process. " 01/01/1999 - "The present study demonstrates that expression and proteolytic activity of caspase-3 is up-regulated in the rat hippocampus after transient forebrain ischemia. " 03/01/2009 - "INO-4885 treatment reduced ischemia/reperfusion-induced protein nitration and caspase 3 activation in a dose-dependent fashion in the range of 3 to 100 microg/kg. However, doses exceeding 100 microg/kg produced nonspecific effects and attenuated its protective ability. " Order ALL the reference details at left...
3.	Anoxia (Hypoxia) 02/01/2009 - "The aim of the present study was to investigate the effect of Shenfu injection on hypoxia/reoxygenation (H/R)-induced apoptosis and the expression of bcl-2 and caspase-3 in cultured neonatal rat cardiomyocytes in vitro. " 07/01/2008 - "The present study tested the hypothesis that mechanism of DNA fragmentation during hypoxia in the cerebral cortex of newborn piglets is mediated by caspase-9-dependent caspase-3 activation. " 03/01/2008 - "Overall results of the present study indicate that hypoxia induces luteal cell apoptosis by enhancing the expression of proapoptotic protein, BNIP3, and by activating caspase-3, and that the induction of apoptosis by hypoxia is partially caused by a decrease in P4 production. " 10/01/2005 - "While fundamental differences between hypoxia/ischaemia in culture and in vivo likely explain the different temporal profiles of Nix, Bax, and caspase-3 activation observed, these studies show that like Bax, mitochondrial accumulation is a common event during Nix activation. " 08/01/2003 - "Recent studies have provided evidence that caspase-3 is an important downstream event after hypoxia-ischaemia in the immature brain, but a minor event in the adult brain. " Order ALL the reference details at left...
4.	Shock 06/01/2002 - "In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3. " 09/01/2008 - "Our observations also suggest a role of caspase-3 and of a particular cleaved form of this caspase during the early signals of heat shock plus TRAIL-induced apoptosis." 01/01/2008 - "OBJECTIVE: To assess the effect of repeated extracorporeal shock waves (ESW) on the apoptosis of renal parenchyma in normal and diabetic rats by the caspase-3 expression. " 09/01/2007 - "The expression of hot shock protein 70(HSP70) and Caspase-3 in LoVo cells were detected by Western blot. " 06/23/2006 - "Herein, we present evidence that heat shock activates an apical protease that stimulates mitochondrial outer membrane permeabilization and processing of the effector caspase-3 in a benzyloxycarbonyl-VAD-fluoromethyl ketone (polycaspase inhibitor)- and Bcl-2-inhibitable manner. " Order ALL the reference details at left...
5.	Carcinoma (Carcinomatosis) 06/01/2009 - "Ovarian carcinoma cells in effusions undergo little apoptosis, but high levels of cleaved caspase-3 are associated with improved survival. " 05/01/2005 - "For this, we applied a combined approach in which both human peripheral blood mononucleated cells (PBMC) and the paired human breast carcinoma cell lines MCF-7, which is caspase-3 deficient, and the caspase-3 transfected MCF-7 (MCF-7casp-3) were used to study the influence of caspase activity on micronuclei. " 12/01/2004 - "This result was confirmed in corollary in vitro studies on a mouse bladder carcinoma cell line in which elevated caspase-3, -8, and -9 activities and decreased mitochondrial membrane potential were observed as a result of transfection with HSVtk and addition of GCV to the medium. " 10/01/2004 - "Studies of the mechanisms by which high levels of caspase-3 expression are tolerated in oral carcinoma cells may identify targets that can be used to harness caspase-3 overexpression for therapeutic benefit." 02/01/2004 - "This study was designed to investigate the expression of Caspase-3 and Bcl-2 to evaluate their effects on the tumorigenesis and progression in bladder transitional carcinoma (BTCC). " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cytochromes c (Cytochrome c)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Caspase 8 (Caspase-8)
5.	Caspase 9
6.	Annexin A5
7.	Proliferating Cell Nuclear Antigen (PCNA)
8.	DNA (Deoxyribonucleic Acid)
9.	Adenosine Triphosphate (ATP)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Resuscitation
4.	Homologous Transplantation (Allograft)
5.	Photochemotherapy (Photodynamic Therapy)

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