Clinical Deterioration

08/01/2006 - "AIP patients showed improvement with steroid treatment, however, most PSC patients showed clinical deterioration. "
02/07/2023 - "She had rapid and profound clinical deterioration after a single dose of steroids. "
10/01/2021 - "In patients with positive RT-PCR results, cell cycle inhibitor drugs were withdrawn, while steroids were maintained at the same level as in patients without clinical deterioration. "
12/01/2018 - "Acute clinical deterioration in patients with spinal DAVFs treated with steroid administration has been described. "
01/01/2018 - "Clinical deterioration was delayed and more patients came off steroids in arm A. "

04/01/2005 - "Patients receiving antibiotics suffered a significantly greater number of unfavorable outcomes (clinical deterioration or death) than those in the early surgical group (P < 0.005). "
01/01/2018 - "There was no report of hospital mortality, clinical deterioration and antibiotic escalation during hospital admission in both groups of study. "
11/28/2023 - "Transient clinical deteriorations, known as paradoxical reactions (PRs), occur in some patients during or after antibiotic treatment. "
05/01/2023 - "If a patient underwent non-bowel surgery or had no diabetes or administered preoperative antibiotics for more than 3 days, the physician should pay more attention to clinical deterioration, even if the seconday culture results are negative."
02/01/2022 - "Post-aspiration antibiotics were not associated with higher mortality, longer length of hospitalization, or an increased rate of clinical deterioration following aspiration. "

10/01/2015 - "He improved after he was starting on corticosteroids in tapering doses, with clinical deterioration at lower doses over a 5-month period. "
01/01/2018 - "Early therapeutic trial of corticosteroids may prevent clinical deterioration, and have invasive pericardial drainage avoided."
12/03/2022 - "If there is clinical deterioration, sudden withdrawal of high-dose corticosteroid during the active phase of CAA-RI should be avoided."
05/01/2018 - "Thus, a high level of suspicion and rapid initiation of corticosteroids are mandatory to prevent uncontrolled clinical deterioration, which might be fatal."
03/01/1990 - "As many patients being treated with corticosteroids have an abrupt clinical deterioration when doses of those medications are decreased, we questioned whether the chest radiograph could depict alterations in disease activity as measured by spirometry in this subset of patients. "

01/01/2022 - "In hospitals with a basic EMR, a biomarker-based ML model could be used to predict clinical deterioration in general wards patients earlier than classical track-and-trigger systems, thus enabling appropriate clinical interventions for patient safety and improved outcomes."
01/01/2021 - "This study highlights the importance of early examination and periodical monitoring of cardiac biomarkers, especially for patients with early CI or at risk of clinical deterioration."
01/01/2019 - "This study evaluated if PERSEVERE, PERSEVERE-II, or the PERSEVERE biomarkers, can reliably estimate the risk of clinical deterioration and 28-day mortality among immunocompromised pediatric patients. "
01/01/2023 - "For PwP with elevated levels of all three biomarkers, clinical deterioration was significant, as indicated by UPDRS-II scores, postural instability and gait disturbance subscores of UPDRS-III, and MMSE score. "
01/01/2022 - "Early Prediction of All-Cause Clinical Deterioration in General Wards Patients: Development and Validation of a Biomarker-Based Machine Learning Model Derived From Rapid Response Team Activations."

11/01/2023 - "Consequently, when compatible symptoms appear, an early diagnosis should be sought in order to start specific antiviral treatment as soon as possible to avoid clinical deterioration of the patient. "
01/01/2010 - "Monitoring HBV genotypic resistance mutation markers and patterns is therefore shown to be beneficial for optimizing antiviral therapies and for avoiding clinical deterioration."
06/30/2021 - "Because of rapid clinical deterioration and the exhaustion of other treatment options, the family and attending physicians requested a compassionate use of adult allogeneic bone marrow-derived mesenchymal stem cells (MSC) in addition to commonly used immunosuppressive, antiviral, and supportive therapy. "
08/01/2019 - "Clinical deterioration and the need for liver transplantation (LT) may arise despite previous antiviral treatment. "
12/01/1987 - "Since persistence of HIV-ag, except possibly in African cases, is strongly associated with clinical deterioration, HIV-ag appears to be a suitable marker for, independent of their clinical status, selecting individuals for antiviral therapy and also for monitoring the efficiency of such therapy."

07/01/1996 - "It was found that metoprolol was well tolerated, improved symptoms and cardiac function, and prevented clinical deterioration in patients with symptomatic idiopathic dilated cardiomyopathy. "
12/11/1993 - "In patients with idiopathic dilated cardiomyopathy, treatment with metoprolol prevented clinical deterioration, improved symptoms and cardiac function, and was well tolerated."
03/12/2002 - "We looked at evidence of clinical deterioration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) by analyzing events and symptoms during the first 90 days. "
11/01/2020 - "The tachycardia persisted to result in clinical deterioration until reversion with urgent intravenous metoprolol. "
01/12/1994 - "Giving metoprolol to patients with symptomatic idiopathic dilated cardiomyopathy prevents clinical deterioration, improves symptoms, cardiac function, and quality of life."

01/01/2007 - "Serum magnesium level and clinical deterioration in Alzheimer's disease."
01/01/2013 - "Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward a reduction in clinical deterioration due to delayed cerebral ischemia (DCI) and an improvement in clinical outcomes. "
07/01/1975 - " This therapeutic problem in malnutrition is illustrated by three different examples of clinical deterioration when caloric and vitamin replenishment have been undertaken in the face of magnesium deificiency."
10/01/2014 - "Comorbid pneumonia and emergency department administration of intravenous magnesium or subcutaneous terbutaline were associated with prolonged therapy and clinical deterioration. "
11/01/2020 - "A vitamin D / magnesium / vitamin B12 combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. "

06/06/2023 - "All mild illness cases showed no clinical deterioration or requirement for supplemental oxygen. "
04/19/2021 - "The contributing factor to the morbidity and mortality associated with this virus is the rapid clinical deterioration as a result of a heightened inflammatory response, requiring supplemental oxygen. "
01/01/2021 - "While such patients may have mild complaints as related to the real impairment of alveolo-capillary oxygen exchange, severe hypoxaemia is a negative prognostic factor of outcome in this state where severe clinical deterioration may rapidly appear. "
10/01/2020 - "Day fourteen of admission heralded the start of progressive clinical deterioration with rapid increase in oxygen demands. "
10/01/2020 - "In addition to the clinical and usual evaluations (eg, breathing frequency, breathing pattern, oximetry, and oxygen flow requirements), early warning scoring systems have been developed to detect clinical deterioration in acutely ill patients. "

01/01/2023 - "One year after discontinuation of epoprostenol, the patient remains in WHO FC I and has no signs of clinical deterioration. "
11/01/2009 - "A cost-utility model simulated the treatment of patients with PAH of FC III. Patients remained on the selected intervention until death or clinical deterioration to FC IV, which would trigger initiation of epoprostenol treatment. "
09/01/2007 - "Patients with clinical deterioration were returned promptly to epoprostenol. "
01/01/2007 - "Accepted indications are severe clinical deterioration (New York Heart Association class III or IV) despite available medical treatments including intravenous epoprostenol. "
04/01/2004 - "Three patients, treated for 3-9 months, experienced clinical deterioration during epoprostenol administration, with a significant increase in PVR in two patients. "

04/01/2022 - "Due to a significant number of relapses and clinical deterioration despite other immunosuppressive drugs, tocilizumab was initiated and induced a long remission period up to 44 months. "
08/01/2022 - "Following tocilizumab intervention, 75 (75.0%) patients showed clinical improvement, continued to recover, and were safely discharged from the hospital, while in 25 (25.0%) patients, TCZ failed to prevent clinical deterioration, and patients eventually died in the hospital. "
11/01/2020 - "Selection of patients for use of Tocilizumab was based on severity of disease, rapid clinical deterioration, presence of CRS and absence of any absolute contraindication to Tocilizumab. "
07/14/2020 - "Our findings suggest that early use of tocilizumab might be beneficial in preventing clinical deterioration and intubation in select COVID-19 patients."
07/14/2020 - "Early Use of Tocilizumab May Prevent Clinical Deterioration in Select COVID-19 Patients: A Case Series."

12/01/2023 - "The use of MR-proADM might be extremely beneficial in triaging, assessing probable therapy escalation, predicting potential complications during therapy or significant clinical deterioration of patients, and avoiding admission which may not be necessary. "
12/01/2023 - " use of MR-proADM might be beneficial in triaging, assessing probable therapy escalation, predicting potential complications during therapy or significant clinical deterioration of patients, and avoiding admission which may not be necessary.For"
01/01/2020 - "Prompt treatment with antifungal therapy is the mainstay of treatment with surgical resection reserved in cases of extensive disease burden or clinical deterioration. "
09/01/2003 - "In this study, 24 months of rhGH was a safe and effective therapy for the disproportionate short stature of SHOX haploinsufficiency, with no clinical deterioration of BMD."
01/01/2016 - "Despite appropriate supportive therapy, the patient initially improved, but subsequently had clinical deterioration. "

04/01/2018 - "In the field of Intensive Care Medicine, improved survival has resulted from better patient care, the early detection of clinical deterioration, and the prevention of iatrogenic complications, while research on new treatments has been followed by an overwhelming number of disappointments. "
01/01/2023 - "Clinical deterioration in this study is measured by in-hospital mortality and/or admission to critical care. "
12/01/2021 - "The purpose of this study is to test whether or not early warning scores will allow us to estimate early clinical deterioration within 24 hours and predict readmission to intensive care. "
02/01/2017 - "The study sought to assess the frequency and prognostic value of hyperattenuating adrenal glands on contrast-enhanced computed tomography (CT) scans of surgical intensive care unit (ICU) patients with acute clinical deterioration. "
01/01/2023 - "At least 85% of unplanned admissions to critical care wards for children and young people (CYP) are associated with clinical deterioration. "

06/01/2016 - "Among the 200 patients listed, 60% (119/200) underwent transplantation, 22% (44/200) died on the waiting list, 7% (13/200) were delisted for clinical deterioration and 11% (21/200) were delisted due to clinical improvement, with 2% (3/200) being still active on the waiting list. "
12/01/1996 - "Based on the results of this pilot-controlled trial, better indices of prognosis will be required, in addition to those used to select for transplantation, if patients at an earlier stage of clinical deterioration are to be included in future studies."
07/01/2023 - "Candidates under both policies had similar 2-year survival after waitlisting, as well as a similar cumulative incidence of transplantation and de-listing due to death and/or clinical deterioration. "
07/01/2023 - "Secondary outcomes included incidence of transplantation from the waitlist and de-listing due to either death or clinical deterioration. "
12/01/2022 - "Competing outcomes for the waitlist analysis included rates of transplantation, recovery, and death or clinical deterioration. "

02/01/2008 - "Conservative treatment including compressions garments and lymphatic drainage is suitable to prevent ongoing clinical deterioration although both diseases cannot be cured. "
05/01/2021 - "After initial conservative management, a clinical deterioration prompted urgent reevaluation and successful embolization of the liver through transarterial embolization. "
12/01/2020 - "It should always be considered and should promptly be performed when the conservative treatment is not successful and clinical deterioration occurs. "
01/01/2020 - "A surgical approach is reserved for a large tear with mediastinum contamination, or clinical deterioration after unsuccessful conservative management. "
10/15/2013 - "Three of these assessed MRI predictors of clinical deterioration in the case of conservative treatment and 17 evaluated MRI anatomic or cord characteristics that could predict surgical outcome or adverse events. "

07/11/2017 - "Modern drug therapy provides a significant improvement in patient symptomatic status and a slower rate of clinical deterioration. "
04/01/2011 - "The maintenance strategy consists of pursuing an appropriate, well-tolerated treatment after the end of first-line chemotherapy in order to maintain the initial therapeutic benefit and to avoid rapid clinical deterioration that would rule out further treatment. "
11/01/2023 - "The dog initially responded to a multidrug chemotherapy protocol but clinical deterioration occurred 3 months later. "
01/01/2021 - "The patient had rapid clinical deterioration and deceased before chemotherapy initiation. "
06/26/2020 - "CONCLUSIONS This case is considered unique in terms of rapid clinical deterioration and lack of improvement following the standard EP chemotherapy regimen. "