DCC Receptor

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

Also Known As:

DCC Tumor Suppressor Protein; DCC-Netrin-1 Receptor; Deleted in Colorectal Carcinoma Protein; DCC Netrin 1 Receptor; Receptor, DCC; Receptor, DCC-Netrin-1

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Netrin Receptors: 84
        DCC Receptor: 64
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - DCC Receptor: 64
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - DCC Receptor: 64
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - DCC Receptor: 64

human DCC protein

Bio-Agent Context: Research Results