ADAM10 Protein

A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bruno, Tullia C: 1 article (01/2022)
2.	Calderon, Michael: 1 article (01/2022)
3.	Cillo, Anthony R: 1 article (01/2022)
4.	Dadey, Rebekah: 1 article (01/2022)
5.	Ferris, Robert L: 1 article (01/2022)
6.	Herman, James G: 1 article (01/2022)
7.	Joyce, Sonali: 1 article (01/2022)
8.	Kirkwood, John M: 1 article (01/2022)
9.	Kunning, Sheryl: 1 article (01/2022)
10.	Lampenfeld, Caleb: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Here, we demonstrated that approximately a third of cancer patients analyzed in this study have peripheral CD8+ T cells that expressed robust intracellular LAG3 (LAG3IC), but not surface LAG3 (LAG3SUR) due to a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) cleavage. " 05/01/2015 - "The immunohistochemical analysis revealed that the ADAM10 protein was located on both the tumor cell membrane and blood vessel walls within tumor tissues. " 10/01/2013 - "The expression of ADAM10 protein in HCC tissues was significantly higher when compared to that in adjacent non-tumor tissues (P<0.05). " 01/01/2004 - "ADAM-10 protein was predominantly membrane bound in benign glands but showed marked nuclear localization in cancer glands. " 05/01/2015 - "In addition, the fact that ADAM10 protein was expressed on cell membranes and blood vessel walls within tumor tissues, indicates that its expression may be associated with invasive tumor growth and peritumoral edema formation."
2.	Squamous Cell Carcinoma of Head and Neck 01/01/2023 - "A disintegrin and metalloproteinase domain-containing protein 10 (ADAM-10) involves in the tumour progression, but the impacts of single-nucleotide polymorphism (SNP) of ADAM-10 on oral squamous cell carcinoma (OSCC) remain unclear. " 08/01/2017 - "The aim of this study was to determine the effect of A disintegrin and metalloprotease 10 (ADAM10) protein expression on the progression, migration and prognosis of hypopharyngeal squamous cell carcinoma (HSCC). "
3.	Osteoarthritis 09/01/2001 - "ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage." 09/01/2001 - "The objective of our study was to determine the tissue distribution and localization of ADAM-10 protein in human and bovine cartilage and the changes it undergoes with cartilage degeneration seen in osteoarthritis (OA) and under the influence of interleukin-1 (IL-1). "
4.	Kidney Neoplasms (Kidney Cancer) 11/01/2011 - "In the present study, we present compelling evidence that PAX2 can bind to the promotor of ADAM10 and regulate ADAM10 protein expression in renal cancer cells. "
5.	Glioma (Gliomas) 01/01/2014 - "This study aims to elucidate the glioma cell-derived ADAM10 (A Disintegrin and metalloproteinase domain-containing protein 10) in the suppression of CD8+ effector T cells by the induction of regulatory B cells. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Disintegrins
3.	Interleukin-1 (Interleukin 1)
4.	Proteins (Proteins, Gene)
5.	Amyloid Precursor Protein Secretases (beta-Secretase)
6.	Metalloproteases (Metalloproteinases)
7.	Glypicans
8.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
9.	Cyclooxygenase 2 (Cyclooxygenase-2)
10.	Facilitative Glucose Transport Proteins (Glucose Transporter)