Disintegrins

A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.

Also Known As:

Networked: 1685 relevant articles (26 outcomes, 170 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bartsch, Jörg W: 17 articles (02/2022 - 01/2005)
2.	Ludwig, Andreas: 14 articles (01/2021 - 02/2006)
3.	Veyradier, Agnès: 14 articles (01/2021 - 01/2009)
4.	Markland, Francis S: 14 articles (11/2020 - 12/2002)
5.	Okada, Yasunori: 14 articles (01/2020 - 07/2004)
6.	Wewer, Ulla M: 13 articles (10/2013 - 10/2003)
7.	Zheng, X Long: 12 articles (01/2022 - 06/2004)
8.	Vanhoorelbeke, Karen: 12 articles (01/2021 - 10/2007)
9.	Blobel, Carl P: 12 articles (01/2020 - 01/2004)
10.	Coppo, Paul: 11 articles (01/2021 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2012 - "In the next article, we go over the results of investigations, both in vitro and in vivo, which have shown promising results, thus revealing that the use of disintegrins could be a promising alternative for the treatment of different neoplasias." 10/01/2016 - "The current study builds upon previous research showing that a disintegrin and metallproteinase (ADAM)28 is involved in the pathogenesis of numerous cancers. " 05/01/2008 - "While many disintegrin studies still involve platelets, previously unexplored interactions with glial cancer, T lymphocytes and the bacteria Yersinia have blazed new trails for this field. " 04/01/2006 - "The aim of the current study was to evaluate the expression of ADAM15 disintegrin (ADAM15) in a broad spectrum of human tumors. " 01/01/2023 - "Also, we have tried to elucidate a possible molecular mechanism behind the action of disintegrins on platelet aggregation and cancer. "
2.	Inflammation (Inflammations) 03/01/2016 - "Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation." 06/01/2015 - "A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast-like synoviocytes and inflammation in rheumatoid arthritis." 01/01/2014 - "A disintegrin and metalloproteinase15 (ADAM15) has been shown to be upregulated and mediate endothelial hyperpermeability during inflammation and sepsis. " 11/01/2011 - "A disintegrin and metalloproteinase-8 (ADAM8) is a potential surrogate of inflammation which has recently been associated with myocardial infarction. " 11/01/2019 - "Mechanistic studies revealed that macrophage HIF-1α activation triggered vascular inflammation, extracellular matrix degradation and elastic plate breakage through increased a disintegrin and metallopeptidase domain 17 (ADAM17), identified as a novel target gene of HIF-1α. "
3.	Thrombotic Thrombocytopenic Purpura 06/15/2023 - "Antibody binding to a plasma metalloprotease, a disintegrin and metalloproteinase with thrombospondin type 1 repeats 13 (ADAMTS13), is necessary for the development of immune thrombotic thrombocytopenic purpura (iTTP). " 02/01/2023 - "Survivors of immune-mediated thrombotic thrombocytopenic purpura (iTTP) are exposed to clinical relapses when a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13 (ADAMTS13) activity decreases during follow-up. " 06/01/2022 - "Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy resulting from an inherited or acquired severe deficiency in a disintegrin and metalloproteinase called ADAMTS-13. " 01/01/2022 - "Immune thrombotic thrombocytopenic purpura (iTTP) is caused by severe deficiency of plasma ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) activity. " 11/01/2019 - "Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra-rare thrombomicroangiopathy caused by an inherited deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). "
4.	Hemorrhage 01/01/2020 - "Improved Antithrombotic Activity and Diminished Bleeding Side Effect of a PEGylated αIIbβ3 Antagonist, Disintegrin." 07/01/2016 - "Improved antithrombotic activity and diminished bleeding side effect of a PEGylated αIIbβ3 antagonist, disintegrin." 03/01/2008 - "This reveals a novel function of the disintegrin domain in hemorrhage formation." 01/01/2019 - "Additionally, novel R(K)GD-containing disintegrin TMV-7 mutants are being designed as safer antithrombotics without causing thrombocytopenia and bleeding." 01/01/2016 - "In addition, a novel RGD-containing disintegrin TMV-7 is being developed as a safer antithrombotic agent with minimal side effects, such as thrombocytopenia and bleeding."
5.	Alzheimer Disease (Alzheimer's Disease) 04/01/2014 - "Earlier studies have demonstrated that a disintegrin and metallopeptidase 10 (ADAM10) levels are reduced in Alzheimer's disease (AD) patients compared with healthy subjects. " 04/01/2014 - "Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease." 06/26/2003 - "ADAM10, a disintegrin and metalloprotease that plays a key role in the pathogenesis of Alzheimer's disease, was recently shown to use PrP(c) as a substrate. " 03/18/2008 - "Neuron-specific ADAM10 overexpression proved beneficial in the APP[V717I] mutant Alzheimer mouse model [Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F (2004) A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. " 12/23/2019 - "Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's disease. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Thrombospondins
3.	Integrins
4.	Snake Venoms (Snake Venom)
5.	Enzymes
6.	echistatin
7.	thiamine triphosphorate (TTP)
8.	Matrix Metalloproteinases (MMPs)
9.	Cytokines
10.	Ligands

Related Therapies and Procedures

1.	Therapeutics
2.	Plasma Exchange
3.	Radiotherapy
4.	Neoadjuvant Therapy
5.	Adjuvant Chemotherapy