pro-brain natriuretic peptide (1-76)

amino-terminal pro-brain natriuretic peptide; marker of cardiac impairment

Also Known As:

Amino-terminal pro-brain natriuretic peptide; N-BNP peptide; N-terminal pro-BNP; NT-BNP; NT-proBNP; NTproBNP; aminoterminal pro-B-type natriuretic peptide; proBNP (1-76); proBNP(1-76)

Networked: 5647 relevant articles (251 outcomes, 1186 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Januzzi, James L: 120 articles (04/2024 - 12/2004)
2.	Solomon, Scott D: 59 articles (05/2024 - 09/2011)
3.	McMurray, John J V: 52 articles (05/2024 - 03/2009)
4.	Bayes-Genis, Antoni: 44 articles (03/2024 - 02/2006)
5.	Cleland, John G F: 41 articles (03/2024 - 02/2006)
6.	Omland, Torbjørn: 36 articles (01/2024 - 01/2003)
7.	Wallentin, Lars: 36 articles (01/2024 - 07/2003)
8.	Lam, Carolyn S P: 35 articles (05/2024 - 09/2011)
9.	Selvin, Elizabeth: 35 articles (05/2024 - 05/2015)
10.	Richards, A Mark: 35 articles (01/2024 - 01/2005)

Related Diseases

1.	Heart Failure 07/17/2007 - "By C-statistic calculations, BNP and NT-proBNP significantly improved the predictive accuracy of the best available model for incident heart failure, and NT-proBNP also improved the model for cardiovascular death. " 03/01/2007 - "While a strategy where initial NTproBNP estimation is cost effective in detecting any causes of heart failure, portable echocardiography remains the most costeffective strategy to assess patients from the community with suspected heart failure." 03/01/2011 - "ST2 is a potent marker of risk in chronic heart failure and when used in combination with NT-proBNP offers moderate improvement in assessing prognosis beyond clinical risk scores." 01/01/2023 - "[In patients hospitalized for acute heart failure, is a strategy combining rapid and close follow-up visits with laboratories (including NT-proBNP) and rapid up-titration of treatments effective and safe?]" 12/01/2017 - "The ROC curve of corrected NT-proBNP diagnostic formula for heart failure was also significantly higher (P = .037).The corrected NT-proBNP diagnostic formula was found to improve the diagnostic accuracy of chronic heart failure."
2.	Stroke (Strokes) 01/01/2023 - "In an older population with additional stroke risk factors, ILR screening for AF was associated with a significant reduction in stroke risk among individuals with higher NT-proBNP levels but not among those with lower levels. " 01/01/2022 - "NT-proBNP improved the discriminative performance of the 'basic' model for all endpoints (c-statistic improvements ranging from 0.007 to 0.050) and provided significant event-NRI for HF (14.3% in women; 10.7% in men) and for stroke in men (9.3%). " 01/01/2023 - "The aim of this study was to investigate NT-proBNP as a potential marker for screening efficacy with respect to AF yield and stroke prevention. " 06/04/2013 - "NT-proBNP improves risk stratification beyond the CHA2DS2VASc score and might be a novel tool for improved stroke prediction in AF. " 08/20/2017 - "The addition of LAD and NT-proBNP to the CHA2DS2-VASc score improved its predictive power for stroke and death, respectively, in this patient cohort. "
3.	Dyspnea (Shortness of Breath) 12/01/2010 - "Dyspnea patients with elevated NT-proBNP concentrations and no improvement in either NT-proBNP or QOL at 30-days are at high risk of mortality and HF hospitalization. " 06/19/2007 - "In a universal health coverage system mandating judicious use of healthcare resources, inclusion of NT-proBNP testing improves the management of patients presenting to emergency departments with dyspnea through improved diagnosis, cost savings, and improvement in selected outcomes." 11/01/2023 - "This study demonstrates the usability of an economical rapid test kit in measuring NT-ProBNP levels to help differentiate the cause of dyspnea in the presenting patient in a resource-limited setting. " 10/01/2023 - "In this study, NT-proBNP alone exhibited the best diagnostic accuracy for diagnosing AHF in elderly patients presenting with acute dyspnea to the emergency departments. " 01/01/2021 - "In conclusion, based on a contemporary trial of patients with acute dyspnea, this analysis reaffirmed that using NT-proBNP as a diagnostic tool may improve the management of patients with dyspnea presenting to EDs and is likely to be cost-saving from the US Medicare perspective."
4.	Cardiovascular Diseases (Cardiovascular Disease) 12/01/2020 - "Furthermore, incorporation of serum NT-proBNP levels into the model consisting of known risk factors for AF and cardiovascular disease significantly improved the predictive ability for developing AF (Harrell's c-statistics: 0.828 to 0.844, p = 0.01; continuous net reclassification improvement: 0.41, p < 0.001; integrated discrimination improvement: 0.031, p < 0.001). " 10/08/2013 - "Accelerated up-titration of RAS antagonists and beta-blockers to maximum tolerated dosages is an effective and safe intervention for the primary prevention of cardiac events for diabetic patients pre-selected using NT-proBNP. " 06/01/2012 - "ED NT-proBNP testing did not affect admission, LOS, 2-year survival, or recurrent cardiac events among study patients but improved diagnosis at discharge, and allowed risk stratification even within the ADHF-likely group. " 10/01/2022 - "NT-proBNP was measured in serum from 18 356 individuals without previous cardiovascular disease in the Generation Scotland Scottish Family Health Study. " 01/01/2021 - "Four of the five studies reported poor functional outcomes in patients with higher BNP/NT-proBNP levels and one study associated higher BNP/NT-proBNP levels with increased risk of adverse cardiac events. "
5.	Myocardial Infarction 01/01/2023 - "Very early administration of SGLT2i after acute myocardial infarction does not show disadvantageous signals with respect to safety and appears to be as effective in reducing NT-proBNP as well as improving structural and functional LV markers as initiation after 2-3 days." 12/01/2014 - "The addition of NT-proBNP to multivariate models improved the C-index by 0.019 for the 'hard' cardiac endpoint (fatal and non-fatal myocardial infarction). " 03/01/2008 - "The inclusion of NT-proBNP improved the accuracy of the model for death or myocardial infarction (C-statistic 0.84 versus 0.76, p = 0.01). " 12/18/2022 - "Prognostic Value of Admission Peak NT-proBNP Combined with Culprit Plaque Types for Predicting Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study." 08/01/2015 - "The authors conducted a systematic review of studies reporting the ability of preoperative NT-proBNP measurements to predict the composite outcome of all-cause mortality and nonfatal myocardial infarction at 30 days after noncardiac surgery. "

Related Drugs and Biologics

1.	Brain Natriuretic Peptide (Natrecor)
2.	Biomarkers (Surrogate Marker)
3.	Natriuretic Peptides
4.	C-Reactive Protein
5.	Troponin I
6.	Troponin T (Troponin T1)
7.	Troponin
8.	sacubitril and valsartan sodium hydrate drug combination
9.	pro-brain natriuretic peptide (1-76)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Percutaneous Coronary Intervention
4.	Cardiac Resynchronization Therapy
5.	Renal Dialysis (Hemodialysis)