Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: The BNP and NT-proBNP levels were strongly related to the incidence of cardiovascular mortality, heart failure, and stroke but not to myocardial infarction. In multivariable models, BNP remained associated with increased risk of heart failure, whereas NT-proBNP remained associated with increased risk of cardiovascular mortality, heart failure, and stroke. By C-statistic calculations, BNP and NT-proBNP significantly improved the predictive accuracy of the best available model for incident heart failure, and NT-proBNP also improved the model for cardiovascular death. The magnitude of effect of ACE inhibition on the likelihood of experiencing cardiovascular end points was similar, regardless of either BNP or NT-proBNP baseline concentrations. CONCLUSIONS: In low-risk patients with stable coronary artery disease and preserved ventricular function, BNPs provide strong and incremental prognostic information to traditional risk factors.
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Authors | Torbjørn Omland, Marc S Sabatine, Kathleen A Jablonski, Madeline Murguia Rice, Judith Hsia, Ragnhild Wergeland, Sverre Landaas, Jean L Rouleau, Michael J Domanski, Christian Hall, Marc A Pfeffer, Eugene Braunwald, PEACE Investigators |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 50
Issue 3
Pg. 205-14
(Jul 17 2007)
ISSN: 1558-3597 [Electronic] United States |
PMID | 17631211
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Biomarkers
- Indoles
- Natriuretic Peptide, Brain
- trandolapril
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Topics |
- Aged
- Analysis of Variance
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage)
- Biomarkers
(blood)
- Chi-Square Distribution
- Coronary Angiography
- Coronary Artery Disease
(blood, drug therapy, mortality)
- Humans
- Indoles
(therapeutic use)
- Middle Aged
- Multivariate Analysis
- Natriuretic Peptide, Brain
(blood)
- Probability
- Prognosis
- Proportional Hazards Models
- Risk Assessment
- Severity of Illness Index
- Survival Analysis
- Treatment Outcome
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