corresponds to cell attachment site of fibronectin; located near carboxyl-terminal region of alpha-chain of fibrinogen; inhibits platelet aggregation & fibrinogen binding to activated platelets
Also Known As:
Arg-Gly-Asp-Ser; RGDS peptide; fibronectin tetrapeptide
Networked: 48 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Wang, Bin: 2 articles (06/2014 - 05/2012)
2. Zhang, Li: 2 articles (06/2014 - 05/2012)
3. Wu, Chin-Chung: 1 article (12/2015)
4. Wei, Chien-Kei: 1 article (12/2015)
5. Chang, Fang-Rong: 1 article (12/2015)
6. Hsieh, Pei-Wen: 1 article (12/2015)
7. Zhao, Xiang: 1 article (04/2015)
8. Ding, Xibing: 1 article (04/2015)
9. Tong, Yao: 1 article (04/2015)
10. Wang, Xin: 1 article (04/2015)

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Neoplasms (Cancer)
3. Thrombosis (Thrombus)
11/15/1993 - "A high dose (20 mg/kg, i.v.) of the anti-adhesive tetrapeptide Arg-Gly-Asp-Ser (RGDS) showed only a slight effect on thrombus formation whereas aspirin was ineffective. "
02/01/2007 - "To obtain a thrombus-targeted plasminogen activator with high affinity for activated platelets and enhanced thrombolytic and antithrombotic potency, we engineered a sequence encoding RGDS (Arg-Gly-Asp-Ser) peptide into the loop between domains II and III of the sequence-deleted mutant of annexin B1 and then constructed a chimaeric plasminogen activator gene mAnxB1-RGDS-ScuPA by fusing ScuPA32k [low-molecular-mass single-chain urokinase (32 kDa)] with the N-terminus. "
03/01/2003 - "The ligand H-Arg-Gly-Asp-Ser-OH (RGDS) which has specific affinity to thrombus was synthesized by liquid phase method and anchored on the surface of liposomes by incorporating its conjugate with DSPE-PEG3,500-COOH into liposomal lipid bilayers, thus thrombus-targeted liposomes were produced. "
01/01/2013 - "In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus. "
04/01/2010 - "In order to increase bio-utilization and thrombus targetability of subtilisin FS33 labeled by fluorescein isothiocyanate (FITC), the surface modified liposomes encapsulating subtilisin FS33 and FITC with a synthetic peptide Arg-Gly-Asp-Ser (RGDS), being putatively a specific antagonist of fibrinogen receptor on platelet membrane, were prepared and used to evaluate the therapeutic efficacy in a rat model thrombotic carotid artery. "
4. Melanoma (Melanoma, Malignant)
5. Acute Lung Injury

Related Drugs and Biologics

1. Peptides
2. Liposomes (Liposome)
3. Subtilisin
4. Fluorescein (Funduscein)
5. Fluorescein-5-isothiocyanate (FITC)
6. Fibrinogen (Factor I)
7. isothiocyanic acid
8. arginyl-glycyl-aspartyl-serine
9. Fibronectins (Fibronectin)
10. Laminin (Merosin)

Related Therapies and Procedures

1. Trabeculectomy (Trabeculoplasty)
2. Artificial Respiration (Mechanical Ventilation)
3. Lasers (Laser)
4. Injections