|1.||Lin, Ya-Jun: 6 articles (07/2013 - 11/2008)|
|2.||Chung, Jing-Gung: 6 articles (05/2010 - 01/2007)|
|3.||Dai, De-Zai: 5 articles (09/2013 - 03/2011)|
|4.||Dai, Yin: 4 articles (09/2013 - 06/2012)|
|5.||Cong, Xiao-Dong: 4 articles (09/2013 - 06/2012)|
|6.||Zhen, Yong-Zhan: 4 articles (01/2013 - 11/2008)|
|7.||Blumenstein, I: 3 articles (07/2013 - 01/2008)|
|8.||Hu, Gang: 3 articles (07/2013 - 01/2011)|
|9.||Bock, H: 3 articles (07/2013 - 01/2008)|
|10.||Zhang, Yun: 3 articles (01/2013 - 06/2012)|
01/01/2015 - "Rhein significantly improved the serum and urine biochemical parameters, and attenuated the glomerular pathological changes and tubulointerstitial fibrosis in IgAN rats. "
01/01/2013 - "The present study firstly reported that rhein attenuates PSC activation and suppresses SHH/GLI1 signaling in pancreatic fibrosis. "
01/01/2011 - "These observations strongly suggest that rhein is a potent inhibitor of renal interstitial fibrosis, and its therapeutic mechanism is, at least in part, blocking interstitial fibroblasts cells activation."
01/01/2011 - "Preventive effects and mechanisms of rhein on renal interstitial fibrosis in obstructive nephropathy."
01/01/2003 - "To investigate the effect of rhein on the development of hepatic fibrosis. "
|2.||Diabetic Nephropathies (Diabetic Nephropathy)
04/01/2008 - "Rhein, an anthraquinone compound isolated from rhubarb, has been proved effective in treatment of experimental diabetic nephropathy (DN). "
11/01/2004 - "To study the mechanisms of anti-diabetic nephropathy of rhein on cultured human mesangial cells (HMCs). "
01/01/2014 - "The molecular mechanism of rhein in diabetic nephropathy."
04/01/2008 - "Inhibition of the hexosamine pathway may be one of the mechanism through which rhein exerts its therapeutic role in diabetic nephropathy."
10/01/1999 - "These results suggest that Rhein might be a hopeful drug for patients with diabetic nephropathy."
01/01/2009 - "However, because of its water insolubility, the anti-tumor efficacy of rhein was limited in vivo. "
08/15/2015 - "Collectively, rhein, being the first identified small molecule inhibitors for SRA, warrants further structure-activity relationship studies, which may lead to development of novel pharmacological intervention for cancer therapy. "
01/01/2009 - "In previous studies, rhein, one of the major bioactive constituents in the rhizome of rhubarb, inhibited the proliferation of various human cancer cells. "
01/01/2009 - "Earlier studies have shown that rhein, one of the major bioactive constituents of the rhizome of rhubarb, inhibits the proliferation of various human cancer cells. "
01/01/2007 - "In this study, the mechanisms of apoptosis by which rhein acts on human cervical cancer Ca Ski cells were examined. "
01/01/2013 - "In this study, we explored whether rhein can reduce the inflammation-induced expression of ECAMs in human umbilical vein endothelial cells (HUVECs) with or without lipopolysaccharide (LPS) stimulation. "
06/01/2012 - "ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats."
09/01/2015 - "In conclusion, the results of the present study provide a novel insight into the protective effects of rhein on LPS‑induced intestinal inflammation, and demonstrate that rhein may act as a beneficial therapeutic agent in the treatment of sepsis-induced intestinal damage."
07/01/2013 - "Rhein improved renal function and reduced renal fibrosis and interstitial inflammation by inducing production of HGF and BMP7."
07/01/2014 - "Furthermore, our study also highlights the potential complications of IKKβ inhibitor (e.g., rhein, diacerein, etc.) application in inflammation disorders, for the overall effects of IKKβ inhibition in various organ systems and disease processes are not easily predictable under all circumstances. "
|5.||Renal Insufficiency (Renal Failure)
01/01/1994 - "Apparent total clearance of rhein was poorly correlated with creatinine clearance and this was related to a decrease of non-renal clearance of rhein in renal insufficiency. "
01/01/1993 - "Apparent total clearance of rhein was poorly correlated with creatinine clearance and this was related to a decrease of non-renal clearance of rhein in renal insufficiency. "
11/01/1998 - "Mild-to-severe (Child Pugh's grade B to C) liver cirrhosis does not change the kinetics of diacerein, whereas mild-to-severe renal insufficiency (creatinine clearance < 2.4 L/h) is followed by accumulation of rhein which justifies a 50% reduction of the standard daily dosage. "
|3.||Non-alcoholic Fatty Liver Disease
|4.||Transforming Growth Factor beta1 (TGF beta 1)
|6.||Bone Morphogenetic Protein 7
|7.||Toll-Like Receptors (Toll-Like Receptor)
|3.||Heterologous Transplantation (Xenotransplantation)
|4.||Drug Therapy (Chemotherapy)
|5.||Chinese Traditional Medicine (Traditional Chinese Medicine)