Sirtuin 1

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

Also Known As:

Silent Mating Type Information Regulation 2 Homolog 1; Sirt1

Networked: 5909 relevant articles (636 outcomes, 1050 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - Histone Deacetylases: 5144
        Group III Histone Deacetylases: 12
        Sirtuins: 2289
        Sirtuin 1: 5909
        human SIRT1 protein
        mouse Sirt1 protein
        rat Sirt1 protein
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Sirtuins: 2289
      - Sirtuin 1: 5909
        human SIRT1 protein
        mouse Sirt1 protein
        rat Sirt1 protein

Experts

1.	Guarente, Leonard: 28 articles (01/2018 - 02/2004)
2.	Liu, Yang: 27 articles (01/2022 - 01/2011)
3.	Yang, Yang: 26 articles (07/2022 - 09/2013)
4.	Zhang, Wei: 24 articles (01/2022 - 11/2011)
5.	McBurney, Michael W: 24 articles (01/2020 - 03/2008)
6.	Liu, Wei: 22 articles (02/2022 - 08/2010)
7.	Wang, Jing: 21 articles (11/2022 - 10/2011)
8.	Koya, Daisuke: 21 articles (10/2020 - 01/2007)
9.	Li, Xiaoling: 20 articles (04/2022 - 10/2007)
10.	Wang, Yan: 19 articles (04/2022 - 07/2013)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2023 - "In conclusion, PEFCS is rich in beneficial phytoconstituents and conferred protection against liver injury by attenuating OS and inflammation and upregulating Nrf2 and SIRT1." 11/14/2022 - "In summary, our results demonstrate that PO ameliorates adipose tissue inflammation through activating SIRT1, which modulates the inflammatory pathway comprising MAPK and NF-κB signals and drives the beneficial reciprocal interactions between adipocytes and macrophages. " 12/01/2020 - "Notably, the SIRT1 inhibitor EX527 attenuated the XNJ-mediated decrease in inflammation in vivo and in vitro.Conclusions: XNJ improved cerebral I/R injury through inhibiting the inflammatory response via the SIRT1 pathway, which may be a useful target in treating cerebral I/R injury." 04/01/2022 - "These protective effects, including inhibiting apoptosis and alleviating inflammation in the IBZ, were partially abolished by EX527, an inhibitor of SIRT1. " 10/01/2019 - "Irisin improved LPS-induced alveolar epithelial barrier dysfunction via suppressing inflammation and apoptosis, and this protective effect might be mediated by activating AMPK/SIRT1 pathways."
2.	Insulin Resistance 09/16/2019 - "This study was designed to evaluate the protective effects of AMPKα and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying mechanisms. " 01/16/2015 - "SIRT1 activators might be useful in the treatment of insulin resistance-related diseases. " 11/01/2022 - "In addition, central metabolic regulators such as SIRT1 and FOXO1 were upregulated while de novo lipogenesis was reduced and β-oxidation was improved in line with an improvement of insulin resistance. " 01/20/2022 - "SIRT1 Mediates Sestrin1-Induced Improvement in Hepatic Insulin Resistance." 01/01/2021 - "N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway."
3.	Fibrosis (Cirrhosis) 11/15/2017 - "Recent studies point out to the protective effects of silent information regulator1 (SIRT1), against different models of organs fibrosis. " 01/01/2022 - "RSV effectively ameliorated myocardial fibrosis and improved cardiac function by regulating Sirt1/Smad3 deacetylation pathway in rat model with DCM." 05/01/2014 - "Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway." 10/21/2022 - "In conclusion, our study revealed the role of APN in antagonizing HS fibrosis by regulating the SIRT1/C/EBPβ/YAP pathway." 01/27/2021 - "This study explores the impacts of intestinal SIRT1 deficiency and TNFα-mediated intestinal abnormalities on the development of cirrhosis-related renal dysfunction. "
4.	Non-alcoholic Fatty Liver Disease 03/19/2018 - "Activation of SIRT1 showed potential against the physiological mechanisms related to NAFLD. " 08/01/2023 - "In conclusion, exogenous H2 S improved NAFLD by inhibiting hepatic ER stress through SIRT1/FoxO1/PCSK9 pathway. " 03/31/2022 - "Turmeric effectively improved SIRT1 levels in patients with NAFLD compared with the placebo. " 01/01/2021 - "QSHY granules improved hepatic steatosis and corrected the BCAA disorder in NAFLD mice, and the related mechanisms regulated the AMPK/SIRT1/UCP-1 pathway and promoted WAT browning." 12/01/2020 - "EA relieved liver injury in NAFLD rats, and its mechanism may be related to the regulation of Sirt1/NF-κB pathway in rats. "
5.	Neoplasms (Cancer) 02/05/2018 - "In particular, it has been shown that inhibition of sirtuin 1 and 2 activities is beneficial for cancer treatment. " 04/01/2013 - "Inhibition of Sirt1 is effective in suppression of ADM and in reducing cell viability in established PDAC tumors. " 02/01/2018 - "SIRT1 and BIRC6 may be linked to tumor progression and could be useful for the treatment of NSCLC." 09/03/2023 - "The aim of the study is to find compounds that could inhibit SIRT1 and thus lower the proliferation of cancer cells. " 01/01/2022 - "In this study, we investigated the effect of blackberry extract on the expression of DNMTs (Dnmt1, Dnmt3a, and Dnmt3b) and HDACs (HDAC1-4 and SIRT1) and its influence on the cellular differentiation and promoter DNA methylation of tumor-related genes using a panel of six human CRC cell lines. "

Related Drugs and Biologics

1.	Resveratrol
2.	Sirtuin 1
3.	Proteins (Proteins, Gene)
4.	Glucose (Dextrose)
5.	NAD (NADH)
6.	Lipids
7.	Antioxidants
8.	SRT1720
9.	Sirtuin 3
10.	Sirtuins

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Punctures
5.	Electroacupuncture