|1.||Kononchik, Joseph P: 1 article (07/2011)|
|2.||Vancini, Ricardo: 1 article (07/2011)|
|3.||Brown, Dennis T: 1 article (07/2011)|
|4.||Stuart, Amanda D: 1 article (08/2006)|
|5.||Brown, T David K: 1 article (08/2006)|
|6.||Kato, Fuminori: 1 article (09/2004)|
|7.||Matsuo, Norifusa: 1 article (09/2004)|
|8.||Yuki, Shunji: 1 article (09/2004)|
|9.||Kato, Masanari: 1 article (09/2004)|
|10.||Kondo, Yoshitaka: 1 article (09/2004)|
12/01/1984 - "Infection of HeLa cells with different viruses induces permeabilization of the cell membrane to protein toxins such as alpha-sarcin. "
07/05/2011 - "Previous studies show that up to 4h post infection cells are permeable to small ions and alpha sarcin suggesting that the plasma membrane is compromised as infection takes place. "
08/01/2006 - "We have also observed that FCV permeabilizes cell membranes early during infection to allow the co-entry of toxins such as alpha-sarcin. "
01/01/1983 - "Although human interferon prevents productive EMC infection, it does not affect the virus-induced entrance of alpha sarcin into the cells. "
09/01/1987 - "The entry of alpha-sarcin, horseradish peroxidase, and luciferase is greatly increased during the early stages of viral infection. "
05/24/2002 - "alpha-Sarcin, the best characterized member of this family, is a potent cytotoxin that promotes apoptosis of human tumor cells after internalization via endocytosis. "
01/01/1991 - "Ultrastructural changes induced by alpha-sarcin in a human pulmonary tumor grown in naked mice."
05/01/1965 - "Aspergillus giganteus MDH 18894 was found to produce alpha sarcin, a new antitumor agent inhibitory to a number of different animal tumors. "
01/01/1991 - "In this work we analysed the morphological changes in tumor cells derived from human pulmonary adenocarcinoma heterotransplanted and grown in naked mice, induced shortly (24 hours) after a single intratumoral injection of alpha-Sarcin (0.4 mg/tumor). "
09/01/2004 - "On the other hand, although its structure is related to that of alpha-sarcin, RNase T1 is noncytotoxic because of its inability to internalize into tumor cells. "
12/14/1990 - "The unbound alpha sarcin, conjugated with the anti-ovarian carcinoma monoclonal antibody MOv17, showed on OVCA 432 a cytotoxicity which was 900 times higher than that exerted by the alpha sarcin alone."
02/26/1991 - "The alpha-sarcin immunotoxin exerted toxic effects in tissue culture against the EJ human bladder carcinoma cell line, expressing the antigen recognised by the Fib75 antibody, inhibiting the incorporation of [3H]leucine by 50% at a concentration of 0.46 nM. The cytotoxic effects of the alpha-sarcin immunotoxin were indistinguishable from those of a Fib75 immunotoxin made with ricin A chain. "
|4.||Ribosome Inactivating Proteins
|5.||Complementary DNA (cDNA)
|6.||DNA-Directed RNA Polymerases (RNA Polymerase)
|8.||Transferrin Receptors (Transferrin Receptor)
|9.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|10.||Peptide Hydrolases (Proteases)