alpha-sarcin

basic protein 150 aa, MW 16 kDa; isolated from aspergillus giganteus; sequence similarity with ribonucleases such as RIBONUCLEASE T1; 85% identity with restrictocin; a ribotoxin cleaving the phosphodiester bond on the 3' side of G4325 in the alpha-sarcin/ricin domain of rat 28S RIBOSOMAL RNA; sometimes called a ribosome-inactivating protein but falls outside the normal definition of plant RIP that de-adenylate rRNA

Also Known As:

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Brown, Dennis T: 1 article (07/2011)
2.	Kononchik, Joseph P: 1 article (07/2011)
3.	Vancini, Ricardo: 1 article (07/2011)
4.	Brown, T David K: 1 article (08/2006)
5.	Stuart, Amanda D: 1 article (08/2006)
6.	Kato, Fuminori: 1 article (09/2004)
7.	Kato, Masanari: 1 article (09/2004)
8.	Kondo, Yoshitaka: 1 article (09/2004)
9.	Matsuo, Norifusa: 1 article (09/2004)
10.	Yuki, Shunji: 1 article (09/2004)

Related Diseases

1.	Infections 08/01/2006 - "We have also observed that FCV permeabilizes cell membranes early during infection to allow the co-entry of toxins such as alpha-sarcin. " 07/05/2011 - "Previous studies show that up to 4h post infection cells are permeable to small ions and alpha sarcin suggesting that the plasma membrane is compromised as infection takes place. " 12/01/1984 - "Infection of HeLa cells with different viruses induces permeabilization of the cell membrane to protein toxins such as alpha-sarcin. " 01/01/1983 - "Although human interferon prevents productive EMC infection, it does not affect the virus-induced entrance of alpha sarcin into the cells. "
2.	Neoplasms (Cancer) 01/01/1991 - "Ultrastructural changes induced by alpha-sarcin in a human pulmonary tumor grown in naked mice." 01/01/1991 - "In this work we analysed the morphological changes in tumor cells derived from human pulmonary adenocarcinoma heterotransplanted and grown in naked mice, induced shortly (24 hours) after a single intratumoral injection of alpha-Sarcin (0.4 mg/tumor). " 09/01/2004 - "On the other hand, although its structure is related to that of alpha-sarcin, RNase T1 is noncytotoxic because of its inability to internalize into tumor cells. " 05/24/2002 - "alpha-Sarcin, the best characterized member of this family, is a potent cytotoxin that promotes apoptosis of human tumor cells after internalization via endocytosis. " 05/01/1965 - "Aspergillus giganteus MDH 18894 was found to produce alpha sarcin, a new antitumor agent inhibitory to a number of different animal tumors. "
3.	Carcinoma (Carcinomatosis) 12/14/1990 - "The unbound alpha sarcin, conjugated with the anti-ovarian carcinoma monoclonal antibody MOv17, showed on OVCA 432 a cytotoxicity which was 900 times higher than that exerted by the alpha sarcin alone." 02/26/1991 - "The alpha-sarcin immunotoxin exerted toxic effects in tissue culture against the EJ human bladder carcinoma cell line, expressing the antigen recognised by the Fib75 antibody, inhibiting the incorporation of [3H]leucine by 50% at a concentration of 0.46 nM. The cytotoxic effects of the alpha-sarcin immunotoxin were indistinguishable from those of a Fib75 immunotoxin made with ricin A chain. "
4.	Virus Diseases (Viral Diseases) 09/01/1987 - "The entry of alpha-sarcin, horseradish peroxidase, and luciferase is greatly increased during the early stages of viral infection. "
5.	Sarcoma 180 05/01/1965 - "Alpha sarcin inhibited sarcoma 180 in mice at a dose of 62.5 mug per kg per day. "

Related Drugs and Biologics

1.	Ions
2.	Immunotoxins (Immunotoxin)
3.	DNA-Directed RNA Polymerases (RNA Polymerase)
4.	Ricin
5.	Ribonucleases (Ribonuclease)
6.	Transferrin Receptors (Transferrin Receptor)
7.	Proteins (Proteins, Gene)
8.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
9.	Peptide Hydrolases (Proteases)
10.	Luciferases