trichothecene

04/01/2004 - "In this study we used bronchoalveolar lavage fluid (BALF) to investigate dose-response (30, 300, 3000 spores/g body weight [BW]) and time-course (3, 6, 24, 48, 96 h post instillation [PI]) relationships in mice to exposure of macrocyclic trichothecene- (JS 58-17) and atranone-producing (JS 58-06) S. "
09/01/2010 - "For the Fusarium trichothecene mycotoxins T-2 and HT-2, a combined (T-2 + HT-2) temporary tolerable daily intake (tTDI) of 0.06 microg kg(-1) body weight day(-1) was proposed at the European level in 2001 (Opinion of the Scientific Committee on Food). "
08/01/1988 - "On orally exposing Salmonella-resistant C3H/HeN mice to the trichothecene T-2 toxin (1 mg/kg body weight), challenging with Salmonella typhimurium, and continuing to dose with T-2 toxin on alternate days for 3 wk, the LD50 for the organism decreased by five orders of magnitude, in comparison with control mice not treated with T-2 toxin. "
01/01/2011 - "In this study, dose-response effects of the trichothecene deoxynivalenol (DON), a common food-borne mycotoxin, were determined on body weight of diet-induced obese mice. "
01/01/2008 - "Immunobiological effects of nivalenol (NIV), a trichothecene mycotoxin produced by Fusarium nivale, were examined in male F344 rats after 90-day dietary exposure at doses of 0, 0.4, 1.5, and 6.9 mg/kg body weight/day (0, 6.25, 25 and 100 ppm, respectively) in a subchronic toxicity study. "

03/01/1982 - "Studies on mechanisms of diarrhea induced by fusarenon-X, a trichothecene mycotoxin from Fusarium species; characteristics of increased intestinal absorption rate induced by fusarenon-X."
03/15/1981 - "Studies on mechanisms of diarrhea induced by fusarenon-X a trichothecene mycotoxin from Fusarium species."
10/01/2012 - "T-2 toxin (T-2), one of the most important and toxic trichothecene mycotoxins, can cause many medical problems, such as diarrhea, nervous disorders, immunodepression and death, and is also believed as an etiological factor of Kashin-Beck disease, an endemic osteochondropathy prevailing in North China. "
02/01/2017 - "Deoxynivalenol (DON), the most commonly occurring trichothecene in nature, may affect animal and human health through causing diarrhea, vomiting, gastrointestinal inflammation, and immunomodulation. "
12/01/1987 - "Studies on mechanisms of diarrhea induced by fusarenon-X, a trichothecene mycotoxin from Fusarium species: fusarenon-X-induced diarrhea is not mediated by cyclic nucleotides."

05/01/2023 - "graminearum infection, deletion mutants of TRI5, the first gene for trichothecene biosynthesis, were generated from strains PH-1, NRRL46422, and NRRL44211 (hereafter 44211) representing the 15-acetyl-DON, 3-acetyl-DON, and NX chemotypes. "
11/01/2021 - "To our knowledge, this is the first report of trichothecene accumulation in wheat stems and heads, as well as grains after FCR infection in natural field conditions. "
01/01/2019 - "Additionally, during the first week of infection, CUL biosynthetic genes were more highly expressed than the TRI5 trichothecene biosynthetic gene. "
11/30/2016 - "Infections with isolates that produced DON and NIV were compared, as well as a trichothecene deficient transformant derived from the NIV-producing isolate. "
12/01/2012 - "Then, a peak of trichothecene accumulation occurred and infection progressed exponentially until the final harvest time. "

02/01/1986 - "These studies are consistent with the possibility that the arachidonate cascade in the central nervous system might have a role in the pathophysiology of trichothecene mycotoxicosis."
07/01/2002 - "Clinical confirmation of trichothecene mycotoxicosis in patient urine."
02/01/2001 - "Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicosis. "
11/01/1997 - "Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicoses. "
12/01/1992 - "Recent concepts in the etiology of Fusarium trichothecene mycotoxicoses have been reviewed. "

12/01/2017 - "We hope that this review will show how trichothecene bioactivities can be exploited to generate therapies against pathogens and cancer."
12/01/2021 - "The excavation of novel trichothecene toxin-resistance genes provide novel molecular clues for controlling the harm of trichothecenes, meanwhile, this study will also pave a new way for the yield improvement of trichothecenes by heterologous expression to facilitate the development of trichothecenes as anti-tumor lead compounds."
02/01/2020 - "Our findings provide experimental evidence suggesting the potential anti-cancer effects of trichothecene sesquiterpenes from a poisonous mushroom."
12/01/2017 - "The type B trichothecene diacetoxyscirpenol specifically inhibits the tumor-promoting factor HIF-1 in cancer cells under hypoxic conditions. "
08/01/1980 - "Low tumor incidence in rats with long-term feeding of fusarenon-X, a cytotoxic trichothecene produced by Fusarium nivale."