Trichothecenes

Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.

Also Known As:

Networked: 97 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wu, Qinghua: 5 articles (01/2022 - 12/2014)
2.	Wu, Wenda: 5 articles (01/2022 - 11/2017)
3.	Wang, Xu: 4 articles (01/2021 - 12/2014)
4.	Pestka, James J: 4 articles (10/2015 - 04/2010)
5.	Kuca, Kamil: 3 articles (01/2021 - 12/2017)
6.	Nepovimova, Eugenie: 3 articles (01/2021 - 12/2017)
7.	Kimura, Makoto: 3 articles (02/2008 - 05/2006)
8.	Nakashita, Hideo: 3 articles (02/2008 - 05/2006)
9.	Nishiuchi, Takumi: 3 articles (02/2008 - 05/2006)
10.	Zhang, Hua: 2 articles (01/2022 - 11/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Structure Elucidation and Anti-Tumor Activities of Trichothecenes from Endophytic Fungus Fusariumsporotrichioides." 01/01/2020 - "We aimed to elucidate the intestinal inflammatory response of the human, non-cancer epithelial HCEC-1CT cells to BUT and to characterize potential combinatory interactions with co-occurring trichothecenes, such as DON and NX-3. " 12/01/2017 - "Second, the anti-cancer potential of trichothecenes and the underlying mechanisms will be discussed. " 12/01/2017 - "The anti-cancer activities of trichothecenes have not been comprehensively summarized. " 12/01/2017 - "Some trichothecenes, especially macrocyclic trichothecenes, also potently kill cancer cells. "
2.	Hypoxia (Hypoxemia) 10/01/2022 - "Increasing lines of evidence have shown that hypoxia and hypoxia-inducible factors (HIFs) are key mediators of trichothecenes, and these toxins appear to be closely related to the "immune evasion" mechanisms. " 04/01/2023 - "Very recent studies further reported an "immune evasion" mechanism in trichothecenes; moreover, hypoxia seems to play important function in this process; nevertheless, whether this "immune evasion" process is present in other mycotoxins, especially in aflatoxins, should be tested. " 01/01/2021 - "Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON)."
3.	Infections 05/01/2023 - "Our results demonstrate that NX trichothecenes play an important role in Fusarium graminearum initial infection as well as FHB spread. " 05/01/2023 - "NX Trichothecenes Are Required for Fusarium graminearum Infection of Wheat." 05/15/2014 - "Trichothecenes concentration showed a strong trend of decline with increase in distance from the infection point. " 05/01/2012 - "Trichothecenes are a group of toxic secondary metabolites produced mainly by Fusarium graminearum (teleomorph: Gibberella zeae) during the infection of crop plants, including wheat, maize, barley, oats, rye and rice. " 08/01/2009 - "The biosynthesis of trichothecenes by Fusarium spp. is highest during infection, but relatively low levels are produced from saprophytic growth in axenic culture. "
4.	Poisoning 08/01/2004 - "This may be one reason why acute poisonings are rare incidences and why the limits of the tolerable daily intake (TDI) levels are exceeded only very seldom; however the population group "infant" exceed the preliminary TDI-level for trichothecenes. " 01/01/1996 - "Samples of the toxic Brazilian plant, Baccharis coridifolia, which is responsible for numerous cases of livestock poisoning in southern Brazil and Argentina, were collected during the growing season, and the toxicities in calves of the plant materials were correlated with the levels of macrocyclic trichothecenes present. " 01/01/1985 - "Macrocyclic trichothecenes: cause of livestock poisoning by the Brazilian plant Baccharis coridifolia." 01/01/1977 - "Since these toxicological characteristics coincide with a major symptom of intoxicated humans and farm animals induced by consumption of moldy cereals and feeds, the red-mold toxicosis and bean-hulls poisoning in Japan, moldy corn toxicosis in U.S.A., A.T.A., stachybotryotoxicosis and dendrochiotoxicosis in Europe, are originated from a common toxicant, trichothecenes. " 09/01/2011 - "In ecological surveys in China, DON and other trichothecenes have been implicated in acute poisoning episodes and linked with the incidence of esophageal cancer. "
5.	Mycotoxicosis (Fungus Poisoning) 11/19/2022 - "DON, one of the most abundant trichothecenes found in cereals, has been implicated in mycotoxicosis in both humans and farm animals. " 01/01/2012 - "Following their ingestion, intestinal epithelial cells are exposed to concentrations of these trichothecenes high enough to cause mycotoxicosis. " 01/01/2003 - "In strains implicated in mycotoxicosis, not all produce detectable trichothecenes. " 10/01/1983 - "In this paper we will attempt to answer the question, "What is Yellow Rain?", summarize some of the massive data on microtoxins and mycotoxicoses, discuss the toxicology of the trichothecenes, give a brief historical perspective on chemical warfare, and touch on some of the political implications of these developments. " 11/01/2011 - "Deoxynivalenol (DON), one of the most abundant trichothecenes found on cereals, has been implicated in mycotoxicoses in both humans and farm animals. "

Related Drugs and Biologics

1.	Mycotoxins
2.	trichothecene
3.	Aflatoxins
4.	T-2 Toxin (T 2 Toxin)
5.	deoxynivalenol
6.	Zearalenone
7.	Proteins (Proteins, Gene)
8.	Fumonisins
9.	Virulence Factors (Pathogenicity Factors)
10.	Enzymes