Effects of deoxynivalenol consumption on body weight and adiposity in the diet-induced obese mouse.

Abstract

The potential for the obese state to alter sensitivity to toxic chemicals is poorly understood. In this study, dose-response effects of the trichothecene deoxynivalenol (DON), a common food-borne mycotoxin, were determined on body weight of diet-induced obese mice. In study 1, the effects of feeding adult female B6C3F1 mice a high-fat diet (HFD; 60% kcal from fat) containing 0, 2, 5, or 10 ppm DON for 10 wk on body weight and adiposity were compared. Mice consuming 5 or 10 ppm DON exhibited a 15 and 24% decrease in weight gain and a 50 and 83% reduction in periuterine fat, respectively. In study 2, mice were fed HFD for 8 wk to induce obesity and the effects of consuming HFD + 0, 2, 5, or 10 ppm DON for 8 wk were then determined. Mice fed 5 or 10 ppm DON exhibited a 16 and 23% weight reduction and a 0 and 40% periuterine fat reduction, respectively. In a follow-up experiment, food consumption was measured prior to and after the transition from HFD to HFD + 10 ppm DON. Exposure to DON was found to lower HFD consumption within 1 d, with significant weight loss in DON-fed mice evident after 6 d. In both studies 1 and 2, consumption of 5 or 10 ppm DON diminished circulating levels of insulin-like growth factor acid-labile subunit. Taken together, DON consumption lowered weight gain and produced weight loss in diet-induced obese mice at higher thresholds than that observed previously in normal B6C3F1 mice.

• Authors: C J Amuzie, B M Flannery, A M Ulrich, J J Pestka
• Journal: Journal of toxicology and environmental health. Part A (J Toxicol Environ Health A) Vol. 74 Issue 10 Pg. 658-67 ( 2011) ISSN: 1528-7394 [Print] England
• PMID: 21432715 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Poisons
• Trichothecenes
• deoxynivalenol

Topics

• Adiposity (drug effects)
• Animals
• Body Weight (drug effects)
• Diet
• Dose-Response Relationship, Drug
• Female
• Mice
• Mice, Obese
• Poisons (administration & dosage, toxicity)
• Trichothecenes (administration & dosage, toxicity)